Effect of Dialysate Temperature on Peritoneal Clearances

Abstract

Peritoneal dialysis was performed in 18 uremic patients using both room temperature (27–31°C) and pre-warmed (37^°C) dialysate. There were no significant differences between the two periods of the following parameters: urea clearance, creatinine clearance, inulin clearance, ratio of inulin to urea clearance, ratio of inulin to creatinine clearance, drainage volume, dialysate flow rate, ultrafiltration rate and total protein loss. Since the peritoneal dialysis efficiency was not improved by warming dialysate in this range of temperature, the warming procedure is not necessary in the countries where the average room temperature is 29°C (27–31°C). The exclusion of this procedure will decrease the work load and lessen the chance of dialysate contamination.

Effect of Chlorpromazine on Peritoneal Clearances

“…In addition, all showed improvement of uremic symptoms. The consis-Indraprasit/Sooksriwongse [8], was again found in this experiment. Therefore, the average values of the repeated studies were used for comparing the control and chlor promazine periods.…”

“…The ultrafiltration rate was calculated by subtracting 1,500 ml from the drainage volume per exchange and then divided by the dialysis time per exchange. Urea-N, inulin and osmolality in the plasma and dialysate, and also protein in the dialysate were analyzed by the methods used in the previous study [8]. The peritoneal clearance was calculated by the formula C = UV/P, where C = peritoneal clearance, U = concen tration of the substance in the dialysate, V = dialysate flow rate in ml/min, P = concentration of the substance in the plasma.…”

Gentamicin Removal during Intermittent Peritoneal Dialysis

“…Urea nitrogen, creatinine, and inulin in serum and dialysate and protein in the dialysate were analyzed by the method used i n the previous study [6], The peritoneal clearance values were calculated by the formula C = UV/P, where C represents the peritoneal clearance, U and P the concentrations of the substances in dialysate and serum, respec tively, and V the dialysate flow rate. For pharmacokinetic analysis, the serum gentamicin concentrations were plotted versus time on a semilogarithmic paper, and linear regression analysis was used to fit the elimination phase of the plot as a first-order elimination linear line.…”

Short-Term Effect of 4% Hypertonic Glucose as Compared to 4% Mixed Hypertonic Mannitol Solution in Conventional Peritoneal Dialysis

“…However, ex changes of two hypertonic solutions were intervened by four ex changes of regular 1.5% G of 1,500 ml each. The solutions were at room temperature and were not prewarmed to body temperature when instilled into the peritoneal cavity -a process which took 10-15 min [12], The dwell time was 30 min and the complete drainage was achieved by gravity in 60-75 min. Blood samples and aliquots were collected at the end of the 2"',,6lh, I0"1, and 14"' exchanges and sent for determination of glucose, urea nitrogen, creatinine, mannitol, elec trolytes, uric acid, total protein, calcium, and phosphorus.…”