Effect of Diabetes on Post-stroke Recovery: A Systematic Narrative Review

Yang, Seoyon; Boudier‐Revéret, Mathieu; Kwon, SuYeon; Lee, Min Young; Lee, Hee Jin

doi:10.3389/fneur.2021.747878

Cited by 14 publications

(9 citation statements)

References 83 publications

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“…In addition, up to half of stroke survivors and individuals with T2DM experience fatigue ( 7 , 8 ) and/or depression ( 9 , 10 ). Added up these factors make this group particularly vulnerable, prone to sedentary behavior (SB) ( 11 , 12 ), poor ability to perform activities of daily living (ADL) ( 13 ), and low quality of life (QoL) ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

“…This theory has previously been used in co-creation processes ( 22 , 26 , 27 ) but co-creation frameworks have not been applied for a population of stroke survivors with T2DM ( 28 ). However, co-creation may be a feasible way to obtain a better understanding of SB and PA behaviors in this population as T2DM, SB and low levels of PA increase the risk of stroke ( 5 , 6 , 14 ), poor post-stroke recovery ( 13 , 42 ), morbidity, and mortality ( 18 , 19 ). Therefore, interventions that aim for beneficial effects of PA in stroke survivors with T2DM are desirable ( 43 ).…”

Section: Introductionmentioning

confidence: 99%

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Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

Bodilsen

Aadahl²,

Wienecke³

et al. 2023

Front. Rehabil. Sci.

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PurposeType 2 diabetes and sedentary behavior pose serious health risks in stroke survivors. Using a co-creation framework, this study aimed to develop an intervention in collaboration with stroke survivors with type 2 diabetes, relatives, and cross-sectoral health care professionals to reduce sedentary behavior and increase physical activity.Materials and methodsThis qualitative explorative study used a co-creation framework consisting of a workshop and focus group interviews with stroke survivors with type 2 diabetes (n = 3), relative (n = 1), and health care professionals (n = 10) to develop the intervention. A content analysis was used to analyze data.ResultsThe developed “Everyday Life is Rehabilitation” (ELiR) intervention consisted of a tailored 12-week home-based behavior change intervention with two consultations of action planning, goal setting, motivational interviewing, and fatigue management including education on sedentary behavior, physical activity, and fatigue. The intervention has a minimalistic setup using a double-page paper “Everyday Life is Rehabilitation” (ELiR) instrument making it implementable and tangible.ConclusionsIn this study, a theoretical framework was used to develop a tailored 12-week home-based behavior change intervention. Strategies to reduce sedentary behavior and increase physical activity through activities of daily living along with fatigue management in stroke survivors with type 2 diabetes were identified.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

Bodilsen

Aadahl²,

Wienecke³

et al. 2023

Front. Rehabil. Sci.

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“…T2D is a strong risk factor for stroke [ 2 ] and the leading cause of mortality from cardiovascular disease [ 3 ]. T2D also worsens stroke recovery [ 4 ] and increases the disability burden, being a strong predictor of post-stroke dependency on assistive care [ 5 , 6 , 7 , 8 ]. Despite the availability of pharmacological and lifestyle change strategies that reduce stroke risk in T2D [ 3 ], efficacious therapies to improve post-stroke recovery and reduce stroke sequelae in this group of people are entirely lacking.…”

Section: Introductionmentioning

confidence: 99%

The Pre-Stroke Induction and Normalization of Insulin Resistance Respectively Worsens and Improves Functional Recovery

Vercalsteren

Karampatsi

Dekens

et al. 2023

IJMS

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Type 2 diabetes (T2D) impairs post-stroke recovery, and the underlying mechanisms are unknown. Insulin resistance (IR), a T2D hallmark that is also closely linked to aging, has been associated with impaired post-stroke recovery. However, whether IR worsens stroke recovery is unknown. We addressed this question in mouse models where early IR, with or without hyperglycemia, was induced by chronic high-fat diet feeding or sucrose supplementation in the drinking water, respectively. Furthermore, we used 10-month-old mice, spontaneously developing IR but not hyperglycemia, where IR was normalized pharmacologically pre-stroke with Rosiglitazone. Stroke was induced by transient middle cerebral artery occlusion and recovery was assessed by sensorimotor tests. Neuronal survival, neuroinflammation and the density of striatal cholinergic interneurons were also assessed by immunohistochemistry/quantitative microscopy. Pre-stroke induction and normalization of IR, respectively, worsened and improved post-stroke neurological recovery. Moreover, our data indicate a potential association of this impaired recovery with exacerbated neuroinflammation and a decreased density of striatal cholinergic interneurons. The global diabetes epidemic and population aging are dramatically increasing the percentage of people in need of post-stroke treatment/care. Our results suggest that future clinical studies should target pre-stroke IR to reduce stroke sequelae in both diabetics and elderly people with prediabetes.

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“…It is imperative to recognize the related markers and factors associated with poststroke results in arrange to direct clinical stroke administration way better. Emerging evidence suggested that metabolic related factors, such as obesity, insulin resistance, type 2 diabetes mellitus, have a great implication for stroke incidence as well as its prognosis (Lau et al., 2019; Rodríguez‐Castro et al., 2019; Yang et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Emerging evidence suggested that metabolic related factors, such as obesity, insulin resistance, type 2 diabetes mellitus, have a great implication for stroke incidence as well as its prognosis (Lau et al, 2019;Rodríguez-Castro et al, 2019;Yang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Predicted resting metabolic rate and prognosis in patients with ischemic stroke

et al. 2023

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Purpose Resting metabolic rate (RMR) could represent metabolic health status. This study aims to examine the association of the predicted RMR with 1‐year poor functional outcome and all‐cause mortality in patients with ischemic stroke as a proxy of metabolic profile. Methods A total of 15,166 patients with ischemic stroke or transient ischemic attack (TIA) from the Third China National Stroke Registry (CNSR‐III) were enrolled in this study. The Harris–Benedict equation based on sex, age, weight, and height was used to predict RMR. The primary endpoints were poor functional outcome defined as ≥3 modified Rankin Scale (mRS) score and all‐cause mortality within 1 year. The association between predicted RMR and prognosis was assessed by multivariable regression analysis. Besides that, subgroup analysis of age, sex, and body mass index (BMI) with predicted RMR was also performed. Results 12.85% (1657) individuals had poor functional outcome and 2.87% (380) died of whatever causes within 1 year. An inverse association was found between predicted RMR with poor functional outcome and all‐cause mortality. Compared to the lowest quartile, the highest quartile was significantly associated with lower risk of poor functional outcome (adjusted odds ratio [OR], 0.43 [95% confidence interval (CI) 0.33–0.56]) and all‐cause mortality (adjusted hazard ratio [HR], 0.44 [95% CI 0.28–0.71]). No significant interaction was between predicted RMR and specified subgroup. Conclusions Predicted RMR by the Harris–Benedict equation seems to be an independent protective predictor of poor functional outcome and all‐cause mortality after ischemic stroke as a metabolic proxy.

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Effect of Diabetes on Post-stroke Recovery: A Systematic Narrative Review

Cited by 14 publications

References 83 publications

Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

Development of a tailored intervention targeting sedentary behavior and physical activity in people with stroke and diabetes: A qualitative study using a co-creation framework

The Pre-Stroke Induction and Normalization of Insulin Resistance Respectively Worsens and Improves Functional Recovery

Predicted resting metabolic rate and prognosis in patients with ischemic stroke

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