Effect of diabetes on peritoneal function assessed by personal dialysis capacity test in patients undergoing CAPD

Nakamoto, Hidetomo; Imai, Hirokazu; Kawanishi, Hideki; Nakamoto, Masahiko; Murata, Jun; Kumon, Shinichi; Watanabe, Syunsuke; Shiohira, Yoshiki; Ishii, Takeo; Kawahara, Toshihiko; Tsuzaki, Koichi; Suzuki, Hiromichi

doi:10.1053/ajkd.2002.36343

Cited by 20 publications

(17 citation statements)

References 21 publications

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“…In our study, we found that patients with diabetes had higher D/P creatinine (0.74 ± 0.09 vs. 0.65 ± 0.11, p = 0.003) and higher PPL (7.04 ± 2.26 vs. 5.68 ± 1.93 g/24 h; p = 0.013). The impact of diabetes on the properties and anatomy of the peritoneal membrane has been a subject of study: some researchers have found that patients with diabetes have a faster transport status for small solutes [31], whereas others found no differences among the patients already on PD for an extended period, in whom peritoneal fluid could damage the membrane and alter its transport properties [32]. In diabetic patients, an increased serum CRP concentration is associated with endothelial dysfunction, as an evidence of chronic inflammation [33], and Szeto et al .…”

Section: Discussionmentioning

confidence: 99%

Paricalcitol and Peritoneal Protein Loss in Peritoneal Dialysis: A Double-Center Study

et al. 2018

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Background/Aims: Peritoneal protein loss (PPL) is associated with cardiovascular disease and mortality in peritoneal dialysis (PD). Controversial results have been published about the effect of paricalcitol in PPL among PD patients. This study intends to analyze the relationship between paricalcitol and PPL in PD. Methods: In a retrospective study, prevalent PD patients were divided into 2 groups: “with paricalcitol” and “without paricalcitol”. X²-test, Student’s t test, Pearson correlation coefficient and Logistic Regression analysis were applied. Results: Eighty-two patients were included. PPL was lower among patients medicated with paricalcitol (5.17 ± 1.71 vs. 6.79 ± 2.10 g/24 h, p = 0.0001). In multivariate analysis, paricalcitol and dialysate/plasma ratio of creatinine (D/P creatinine) were independently related to PPL (OR 4.270 [1.437–12.684], p = 0.009 and OR 0.205 [0.064–0.659], p = 0.008, respectively), adjusted for diabetes. Conclusion: Paricalcitol and D/P creatinine were independently related to PPL. Paricalcitol may have an effect on PPL in PD patients

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Section: Discussionmentioning

confidence: 99%

Paricalcitol and Peritoneal Protein Loss in Peritoneal Dialysis: A Double-Center Study

et al. 2018

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“…The first possible reason is the different baseline patient characteristics. The high concentrations of glucose in PD dialysate [18,19] and more peritoneal protein loss [20] may produce unfavorable results to diabetic patients. It retards physicians and diabetic patients to choose PD as dialysis modality.…”

Section: Discussionmentioning

confidence: 99%

Comparison of self-reported health-related quality of life between Taiwan hemodialysis and peritoneal dialysis patients: a multi-center collaborative study

Chiang

Hung

et al. 2010

Qual Life Res

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“…These observations indicate that insulin is involved in peritoneal function and its complications via versatile mechanisms. In end-stage renal disease patients with diabetes mellitus, long-term PD is more often complicated by peritoneal dysfunction compared with non-diabetic patients, although the serum concentration of insulin in diabetes patients tends to be higher than that in non-diabetic patients [35,36]. In patients with diabetes mellitus, especially type II diabetes, insulin resistance is recognized as a key characteristic.…”

Section: Discussionmentioning

confidence: 99%

Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells

Kaifu

Kiyomoto

Hitomi

et al. 2008

Nephrology Dialysis Transplantation

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Background. Peritoneal mesothelial cells play an important role in peritoneal dialysis and are often exposed to dialysis fluid containing high glucose levels. Loss of peritoneal function is a major complication associated with long-term peritoneal dialysis. In this study, we hypothesized that high glucose levels induce apoptosis, and that insulin attenuates this apoptosis in peritoneal mesothelial cells. To clarify this hypothesis, we examined the effects of insulin on the phosphatidylinositol 3-kinase/Akt signaling pathway and apoptosis in rat peritoneal mesothelial cells. Methods. Phosphorylated insulin receptor and Akt were detected by western blot analysis. Apoptosis was evaluated by measuring caspase 3 activity and by TUNNEL staining. Results. Insulin (100 nmol/L) increased tyrosine phosphorylation of insulin receptor in peritoneal mesothelial cells. Furthermore, insulin (1-100 nmol/L) dosedependently stimulated Akt phosphorylation. Treatment with the phosphatidylinositol 3-kinase inhibitors wortmannin (100 nmol/L) and LY294002 (10 µmol/L) attenuated insulin-induced Akt phosphorylation, indicating that insulin phosphorylates Akt via a phosphatidylinositol 3-kinase-dependent pathway. Insulin attenuated caspase 3 activity and decreased the number of TUNNEL-positive cells. The phosphatidylinositol 3-kinase inhibitors and overexpression of a dominant-negative mutant of Akt inhibited the effect of insulin on apoptosis.Conclusions. The present data indicate that insulin attenuates high glucose-induced apoptosis via the phosphatidylinositol 3-kinase/Akt signaling pathway in peritoneal mesothelial cells. Therefore, the insulin signaling pathway may play a protective role in peritoneal function.Correspondence and offprint requests to: Hideyasu Kiyomoto,

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Effect of diabetes on peritoneal function assessed by personal dialysis capacity test in patients undergoing CAPD

Cited by 20 publications

References 21 publications

Paricalcitol and Peritoneal Protein Loss in Peritoneal Dialysis: A Double-Center Study

Paricalcitol and Peritoneal Protein Loss in Peritoneal Dialysis: A Double-Center Study

Comparison of self-reported health-related quality of life between Taiwan hemodialysis and peritoneal dialysis patients: a multi-center collaborative study

Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells

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