Effect of di-isopropylfluorophosphate, paraoxon, and dichlorovos on binding of [3H]quinuclidinyl benzylate with synaptic membranes of the rat striatum

Golovko, A. I.; Sofronov, G. A.; Nikolaeva, T. V.; Klyuntina, T. V.

doi:10.1007/bf00809567

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1995

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“…Preparation of the membranes and the procedure of radioligand assay were described previously [1,2]. The reliability of the differences between compared parameters was evaluated using the Student t test.…”

Section: Methodsmentioning

confidence: 99%

Effect of salicylates on the toxicity of GABA-lytics in mice

1995

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Preliminary injection of aspirin and salicylic acid increases the toxicity of picrotoxin, but not of bicuculline. Aspirin inhibits binding of 3H-diazepam and N-methyl-3H -methylphenazepam with membranes from the brain of intact mice. In view of the fact that salicylates reduce the content and sorption capacity of serum albumin, this protein can be assumed to be involved in the detoxieation of picrotoxin.

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Section: Methodsmentioning

confidence: 99%