Effect of Dexmedetomidine on Dose Requirement of Propofol and Thiopentone Induction in Patients Under General Endotracheal Anesthesia

Senapati, Laxman K; Samanta, Priyadarsini

doi:10.22159/ajpcr.2018.v11i6.25198

Cited by 3 publications

(3 citation statements)

References 25 publications

(45 reference statements)

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“…Difference of eyelashes reflex in two groups was 6.12±3.47 seconds which was sta s cally significant ( p<0.05).Sulaiman 4 et al observed that pa ents premedicated with Dexmedetomidine were induced faster compared to those who received Midazolam and Fentanyl which was sta s cally significant (p<0.05). Similar to our observa on, 17 Senapa et al , who conducted a double blinded randomized controlled study observed that Dexmedetomidine decreases Propofol requirement during induc on of anesthesia.…”

Section: Gong Et Al Conducted a Meta-analysis And Systemic Review On supporting

confidence: 89%

Comparative Study of Dexmedetomidine and Fentanyl to Obtund the Pressure Response to Laryngoscopy and Intubation

Thapa

Yadav

Dhakal

2019

Birat J. Health Sci.

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Introduction: Airway manipulation during endotracheal intubation is associated with hemodynamic and cardiovascular responses. Different agents have been used to obtund the pressure response. Objectives: To evaluate the place of Dexmedetomidine for routine use during induction of anesthesia to blunt pressure response to laryngoscopy and intubation. Methodology: One hundred patients of ASA I and II were randomly divided into two groups. Group A received Midazolam (0.05 mg/kg) a n d Fentanyl (2 mcg/Kg) and group B received Dexmedetomidine (0.6 mcg/kg) 10 minutes before induction of anesthesia. Both groups were induced with Propofol (1.5 mg/Kg). In all patients after induction (loss of eye lashes reflex) tracheal intubation was facilitated using Rocuronium 1mg/kg. Baseline heart rate was noted and hemodynamic response to intubation was observed 3, 6 and 9 minutes after intubation. Results: In group A, time for loss of eyelashes reflex was 17.45±2.19 seconds and in group B it was 11.33±2.64 seconds. In group A, after intubation heart rate increased by 11.22±2.37, 5.71±1.68, 2.34±1.73 in3, 6 and 9 minutes respectively. In group A, after intubation MAP increased by 6.49±1.37, 3.30±1.15, and 1.24±1.50 from baseline in 3,6, and 9 minutes respectively. In group B after intubation heart rate increased by 2.49±0.89 from baseline at third minutes, however decreased by 2.85±1.58 and 4.73±1.86 at sixth and ninth minute respectively. In group B, MAP increased from baseline by 3.44±1.06 in third minute however decreased by 2.22±1.38 and 4.24±3.40 at sixth and ninth minutes respectively. Conclusion: Both the agents were observed to obtund pressure response to laryngoscopy and intubation however Dexmedetomidine proved to be better option compared to Fentanyl.

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Section: Gong Et Al Conducted a Meta-analysis And Systemic Review On supporting

confidence: 89%

Comparative Study of Dexmedetomidine and Fentanyl to Obtund the Pressure Response to Laryngoscopy and Intubation

Thapa

Yadav

Dhakal

2019

Birat J. Health Sci.

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“…This approach can be utilized in other cases of difficult airway management also. We suggest proper planning, preparation, and keep every option in account to deal with any circumstance in addition to case-specific strategies [7].…”

Section: Resultsmentioning

confidence: 99%

Combined Use of Video Laryngoscopy and Fiberoptic for Airway Management in a Patient With Fixed Cervical Spine

Moda

Kumar

2018

Asian J Pharm Clin Res

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Airway management may be difficult in patients with fixed cervical spine who have undergone previous spine surgery. Among the various techniques, fiber-optic intubation is a preferred method for securing the airway in such situation. However, it has some limitations also like identification of landmarks, especially in a case of distorted anatomy of the airway. To overcome this inadequacy, we used video laryngoscopy as a complement, to guide the tip of bronchoscope beneath the epiglottis into the trachea and thus achieving the goal. We present a case of difficult airway of fixed cervical spine with distorted anatomy in which combined use of fiberoptic and video laryngoscopy was performed to secure the airway. In our opinion, this technique can be utilized for other difficult airway case scenario also.

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“…This is consistent with the studies done by Walia et al [11] which showed that pre-treatment with dexmedetomidine significantly reduced the dose of propofol. Furthermore, in a study conducted by Senapati et al [12], it was demonstrated that dexmedetomidine as a pre-anesthetic medication significantly reduces intraoperative anesthetic requirement of thiopentone and propofol, with the dose requirement slightly less in case of propofol than thiopentone. Similar results were obtained by El-Shmaa et al [13] in their study.…”

Section: Discussionmentioning

confidence: 98%

Effect of Nebulised Dexmedetomidine on Hemodynamic Response to Intubation

SABU

VARGHESE

CHEERAN

2023

Asian J Pharm Clin Res

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Objective: The aim of the study was to determine the role of nebulized dexmedetomidine in attenuating the stress response to laryngoscopy and intubation and to observe any adverse effects of the drug such as cough, bradycardia, hypotension, and dose-sparing result of propofol. Methods: A prospective and observational study was conducted in a tertiary care teaching hospital for 12 months. A total of 62 patients (ASA 1 and 2) in the age group of 18–65 years scheduled for elective surgery under general anesthesia received either nebulized dexmedetomidine 10 min before intubation (Group A) or Inj. Lignocaine 90 s before intubation (Group B). Post-intubation hemodynamic parameters were compared in both groups. Data collected remained analyzed using SPSS version 16. Results: Both groups were comparable with respect to demographic variables. Nebulization with Inj. Dexmedetomidine showed statistically significant blunting of hemodynamic response in the 1st min following intubation, in Group A. This was seen in the variables such as heart rate, diastolic blood pressure, and mean arterial blood pressure. There was no significant difference in the systolic blood pressure at all points of time. Furthermore, there was no significant change in the variables at 5 and 10 min following intubation. There was a significant decrease in the dose of propofol required for induction in Group A compared to Group B. Conclusion: Nebulization with dexmedetomidine before laryngoscopy and intubation significantly reduced the hemodynamic response to intubation, immediately after intubation.

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Effect of Dexmedetomidine on Dose Requirement of Propofol and Thiopentone Induction in Patients Under General Endotracheal Anesthesia

Cited by 3 publications

References 25 publications

Comparative Study of Dexmedetomidine and Fentanyl to Obtund the Pressure Response to Laryngoscopy and Intubation

Comparative Study of Dexmedetomidine and Fentanyl to Obtund the Pressure Response to Laryngoscopy and Intubation

Combined Use of Video Laryngoscopy and Fiberoptic for Airway Management in a Patient With Fixed Cervical Spine

Effect of Nebulised Dexmedetomidine on Hemodynamic Response to Intubation

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