Effect of Dexamethasone Treatment on Volume and Contrast Enhancement of Intracranial Neoplasms

Hatam, Ahmad; Bergström, Mats; Yu, Zhongjian; Granholm, Lars; Berggren, Britt-Marie

doi:10.1097/00004728-198304000-00017

Cited by 43 publications

(21 citation statements)

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“…In this respect, a significant finding of our study, also corroborated by Hatam et al [13], is that the impression of the amount of leaked contrast agent in contrast enhanced CT scans is not sensitive in detecting the reduction in K after steroid treatment. This is true no matter whether a single scan at one fixed time or multiple scans at different times post injection of contrast agent is/are considered.…”

Section: Discussionsupporting

confidence: 75%

Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography

et al. 1994

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Tumor blood-brain transfer constant of iopamidol (K) and plasma volume (Vp) were measured in 10 patients with primary brain tumors before and after 7 days of dexamethasone treatment (4 x 4 mg per oral per day) using X-ray computed tomography. Both K and Vp decreased significantly after dexamethasone treatment with p < 0.01 and 0.09 respectively according to one-tail paired t-test. The mean percentage decrease in K and Vp was 32% and 10% respectively. Functional images of the two parameters before and after treatment were generated and showed clearly the effect of steroids on the reduction of K in brain tumors. In contrast, when before and after treatment contrast enhanced CT scans were compared, no difference was observed in the enhancement in 8 out of 10 cases. The result obtained support the conclusion that: (1) corticosteroids reduce the blood-brain permeability to small hydrophilic molecules; (2) the X-ray computed tomography method we have developed can be used to measure the K and Vp response of brain tumors to steroid therapy; and, (3) ordinary contrast enhanced CT scans at one fixed time or multiple times after contrast injection are not sensitive in detecting the reduction of K due to steroids.

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Section: Discussionsupporting

confidence: 75%

Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography

et al. 1994

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“…[20], work ing on the same material, reported the effect of the treatment on the volume and contrast enhancement of the tumors. In 2 patients with metastasis there was a considerable de crease in tumor volume, whiie in none of the glioma cases was a significant reduction ob served; in fact, in 1 patient there was an increase in tumor volume.…”

Section: Cat Changesmentioning

confidence: 99%

“…an effect on cerebrospinal fluid (CSF) production and a direct cytotoxic effect on brain tumor cells. The effect of cor ticosteroids, particularly dexamethasone, in CSF production are controversial [20], and whether methylprednisolone acts similarly to dexamethasone or not is not known.…”

Section: Cat Changesmentioning

confidence: 99%

“…Methylprednisolone has a cytotoxic effect in vitro on cultured human glioblastoma [4], and in vivo in rat glioma [6,21], Gurcayet al [20,21] found that in methylprednisolonetreated rats, survival was increased, cerebral edema was decreased, and tumor weight was reduced significantly when compared with controls. In this respect, méthylprednisolone proved to be more potent than dexamethasone [4,9], The biochemical basis for the action of these corticosteroids has been established.…”

Section: Cat Changesmentioning

confidence: 99%

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Effect of Large Doses of Methylprednisolone on Supratentorial Intracranial Tumors

Leiguarda

Sierra

et al. 1985

Eur Neurol

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We studied the action of high doses (500 mg/daily for 7 days) of methylprednisolone sodium succinate in 12 patients with supratentorial intracranial tumors. 10 tumors were malignant (5 gliomas and 5 metastases), and 2 benign (meningiomas). Clinical improvement ranged from moderate to marked after 24–48 h of therapy. In the 5 metastases, mean reduction of peritumoral edema was 27%, and in apparent tumor volume was 18%; in the gliomas, corresponding reductions were 31 and 15%. 1 of the meningioma cases showed a decrease in edema volume of 21%. These results indicate that methylprednisolone, at least for a short period of time, produces a definite decrease in apparent tumor size, in addition to the reduction of peritumoral edema.

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“…A reduction in tissue oedema and a resultant reduction in tumour volume following treatment with steroids is a well-documented phenomenon. 7,8 We have experienced a similar scenario in a 76-year-old lady who had presented with optic nerve inflammation that had resolved on steroid treatment, but imaging revealed the cause to be a nasopharyngeal carcinoma. Further improvement following radiotherapy (which led to reduction in tumour volume) also supports the compressive hypothesis.…”

mentioning

confidence: 94%

Optic neuritis: a rare manifestation of nasopharyngeal carcinoma

Puri

Pepper

2004

Eye

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Effect of Dexamethasone Treatment on Volume and Contrast Enhancement of Intracranial Neoplasms

Cited by 43 publications

References 0 publications

Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography

Effect of steroids on iopamidol blood-brain transfer constant and plasma volume in brain tumors measured with X-ray computed tomography

Effect of Large Doses of Methylprednisolone on Supratentorial Intracranial Tumors

Optic neuritis: a rare manifestation of nasopharyngeal carcinoma

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