Effect of Dexamethasone on TSH Secretion Induced by TRH in Human Obesity

Coiro, V.; Volpi, R.; Capretti, L.; Speroni, G.; Pilla, S.; Cataldo, Simona; Bianconcini, Michele; Bazzani, E.; Chiodera, P.

doi:10.2310/6650.2001.33898

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…The first was on the pituitary level, indicated by lower TSH levels. This suppressive effect is in accordance with literature reports on effects of glucocorticoids [31,32] . The second effect was on the level of peripheral thyroid hormone metabolism reflected in changes in T 3 and rT 3 .…”

Section: Discussionsupporting

confidence: 81%

Postnatal Administration of Dexamethasone for Weaning off the Ventilator Affects Thyroid Function

Buimer¹,

Wassenaer

Kok

2008

Neonatology

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Background: Very preterm neonates are at risk of hypothyroxinemia because of prematurity as well as because of neonatal disease. Hypothyroxinemia is associated with impaired developmental outcome. Preterm infants who cannot be weaned from the ventilator can be treated with dexamethasone. Glucocorticoid administration has been found to alter thyroid hormone parameters. Therefore, dexamethasone treatment in these infants might additionally impair their thyroid function, which could have consequences for developmental outcome. Objective: To assess what changes in thyroid function occur in the first hours after initiating dexamethasone treatment in ventilated preterm infants. Methods: Preterm infants, in whom the decision was taken to start dexamethasone treatment, were included. Thyroxine (T₄), 3,5,3′-triiodothyronine (T₃), reverse T₃ (rT₃), thyroid-stimulating hormone (TSH) and cortisol were determined before and 6–9 h after administration of the first dose of a postnatal dexamethasone course. Details of clinical condition were recorded at both time points. Results: Sixteen very preterm infants were included at a median age of 20 days. While clinical condition was stable between start of dexamethasone and 6–9 h thereafter, TSH and T₃ levels decreased significantly. rT₃ levels significantly increased, resulting in a decrease in the T₃/rT₃ ratio. There was no statistically significant effect on the levels of T₄. Conclusion: Postnatal dexamethasone administration negatively affects thyroid functionin the preterm infant with severe chronic lung disease.

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Section: Discussionsupporting

confidence: 81%

Postnatal Administration of Dexamethasone for Weaning off the Ventilator Affects Thyroid Function

Buimer¹,

Wassenaer

Kok

2008

Neonatology

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“…Meanwhile with respect to the post-DST statistically significant lower neopterin levels in the patient group, the suppressive effects of dexamethasone itself, a synthetic glucocorticoid with a long half-life, should be taken into consideration. Dexamethasone also suppresses other pituitary hormones including prolactin and thyroid-stimulating hormone (TSH) (Olazabal et al 2000;Coiro et al 2001). Second, it was reported that norepinephrine, a neurotransmitter frequently reported to be increased in PTSD, and the HPA axis might lead to the inhibition of cytokine secretion.…”

Section: Discussionmentioning

confidence: 98%

Neopterin levels and dexamethasone suppression test in posttraumatic stress disorder

Atmaca¹,

Kuloğlu²,

Tezcan³

et al. 2002

European Archives of Psychiatry and Clinical Neurosciences

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Neopterin has recently gained growing importance as an immunological marker in psychiatric disorders. In the present study, we aimed to evaluate whether the dexamethasone suppression test (DST) and neopterin were associated with posttraumatic stress disorder (PTSD). Fourteen patients with PTSD and 14 controls were enrolled in the study. A clinical evaluation and measurements of cortisol and neopterin levels before and after DST were performed. Additionally, all patients were assessed by Clinician Administered PTSD Scale (CAPS). There was a significantly higher DST nonsuppression in the patient group than control group. There were positive correlations between the duration of illness and CAPS, basal cortisol or postdexamethasone cortisol levels in the patient group. The mean neopterin levels for both before and after DST were significantly lower in the patient group than control group. In conclusion, our results suggest that not only the patients with PTSD have considerable DST nonsuppression but also PTSD may be associated with neopterin.

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“…The inhibitory effect of dexamethasone was used for monitoring of subclinical hypothyroidism in obese patients. Administration of TRH after dexamethasone increased the TSH level only in hypothyroid patients but not in euthyroid obese patients [23].…”

Section: Effects Of Glucocorticoids On Trh and Tsh Levelsmentioning

confidence: 99%

Role of Glucocorticoids in Regulation of Iodine Metabolism in Thyroid Gland: Effects of Hyper-And Hypocorticism

Nadolnik¹

2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Effect of Dexamethasone on TSH Secretion Induced by TRH in Human Obesity

Cited by 9 publications

References 16 publications

Postnatal Administration of Dexamethasone for Weaning off the Ventilator Affects Thyroid Function

Postnatal Administration of Dexamethasone for Weaning off the Ventilator Affects Thyroid Function

Neopterin levels and dexamethasone suppression test in posttraumatic stress disorder

Role of Glucocorticoids in Regulation of Iodine Metabolism in Thyroid Gland: Effects of Hyper-And Hypocorticism

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