Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study

Polese, Barbara; Izzo, Luana; Mancino, Nicola; Pesce, Marcella; Rurgo, Sara; Tricarico, Maria Cristina; Lombardi, Sonia; Conno, Barbara De; Sarnelli, Giovanni; Ritieni, Alberto

doi:10.3390/nu14122510

Cited by 9 publications

(9 citation statements)

References 55 publications

(63 reference statements)

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“…In contrast, one dietary intervention failed to show significant effects in GERD patients. Dietary nitrate had no significant effect on TLESR, reflux episodes, gastric pH, or reflux symptoms [32].…”

Section: Other Dietary Interventionsmentioning

confidence: 75%

The Efficacy of Dietary Interventions in Patients with Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Intervention Studies

Lakananurak,

Pitisuttithum,

Susantitaphong

et al. 2024

Nutrients

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Background: International guidelines recommend dietary interventions as one of the most important treatments for patients with gastroesophageal reflux disease (GERD). Evidence to confirm the efficacy of these treatment modalities is lacking. The present study aims to evaluate the efficacy of dietary interventions on GERD-related outcomes evaluated in intervention studies on GERD patients. Methods: A systematic review and meta-analysis was performed according to PRISMA. The PubMed/MEDLINE, Web of Sciences, and Scopus databases were utilized for the literature search. Two independent researchers searched for relevant publications published up until June 2023. Intervention studies evaluating the efficacy of dietary interventions in patients with GERD were included. Results: A total of 577 articles were identified during the initial literature search. After reviewing, 21 studies with 16 different types of dietary interventions were included in the analysis. The interventions were divided into low-carbohydrate diets (3 studies), high-fat diets (2 studies), speed of eating studies (3 studies), low-FODMAP diets (2 studies), and other interventions (12 studies). A meta-analysis could be performed for low-carbohydrate diets and speed of eating interventions. Low-carbohydrate diets resulted in a significant reduction in esophageal acid exposure time (mean difference = −2.834%, 95% confidence interval (CI): −4.554 to −1.114), while a slow speed of eating did not lead to a lower percentage of reflux events compared to fast eating (risk ratio = 1.044, 95% CI: 0.543–2.004). Most other interventions showed positive effects in only a single study. Conclusion: Low-carbohydrate diets showed a significant improvement in GERD-related outcomes, while a slow eating speed did not result in a reduction in reflux events. The overall evidence regarding dietary interventions in GERD remains scarce. High-quality, long-term RCTs are still required to confirm the effects of dietary interventions in GERD patients.

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Section: Other Dietary Interventionsmentioning

confidence: 75%

The Efficacy of Dietary Interventions in Patients with Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Intervention Studies

Lakananurak,

Pitisuttithum,

Susantitaphong

et al. 2024

Nutrients

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“…Five studies (two prospective cohort [ 14 , 38 ], two randomised crossover studies in coffee-sensitive individuals [ 39 , 40 ] and one cross-sectional study [ 41 ]) support a positive association between coffee consumption and reflux-like symptoms. However, a recent systematic review shows that the data are particularly conflicting, with multiple studies finding no increased risk of reflux-like symptoms in coffee drinkers [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…We did not identify any interventional studies assessing the effect of reduced coffee intake on symptoms. However, substitution analysis in the cohort study conducted by Mehta et al [38] showed that replacing two servings of coffee with water would reduce the risk of refluxlike symptoms [hazard ratio (HR), 0.96; 95% confidence interval (CI), 0.92-1.00] and a small, randomised study demonstrated significant symptom reduction and antacid use when coffee-sensitive individuals switched to dewaxed coffee (containing less caffeine and chlorogenic acids) [39].…”

Section: Diet and Exercise Advicementioning

confidence: 99%

Management advice for patients with reflux-like symptoms: an evidence-based consensus

Hungin,

Yadlapati,

Anastasiou

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Patients with reflux-like symptoms (heartburn and regurgitation) are often not well advised on implementing individualised strategies to help control their symptoms using dietary changes, lifestyle modifications, behavioural changes or fast-acting rescue therapies. One reason for this may be the lack of emphasis in management guidelines owing to ‘low-quality’ evidence and a paucity of interventional studies. Thus, a panel of 11 gastroenterologists and primary care doctors used the Delphi method to develop consolidated advice for patients based on expert consensus. A steering committee selected topics for literature searches using the PubMed database, and a modified Delphi process including two online meetings and two rounds of voting was conducted to generate consensus statements based on prespecified criteria (67% voting ‘strongly agree’ or ‘agree with minor reservation’). After expert discussion and two rounds of voting, 21 consensus statements were generated, and assigned strength of evidence and Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) rating. Eleven statements achieved the strongest (100%) agreement: five are related to diet and include identification and avoidance of dietary triggers, limiting alcohol, coffee and carbonated beverages, and advising patients troubled by postprandial symptoms not to overeat; the remaining six statements concern advice around smoking cessation, weight loss, raising the head-of-the-bed, avoiding recumbency after meals, stress reduction and alginate use. The aim of developing the consensus statements is that they may serve as a foundation for tools and advice that can routinely help patients with reflux-like symptoms better understand the causes of their symptoms and manage their individual risk factors and triggers.

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“…Apesar dos compostos bioativos presentes no café serem relacionados à diminuição no risco de câncer, diabetes, doenças hepáticas e cardiovasculares, foi observado que também Brazilian Journal of Health Review, Curitiba, v. 7, n. 1, p. 2170-2193, jan./fev., 2024 servem de possíveis indutores para os sintomas da DRGE, como azia e regurgitação. Sendo assim, ao estudar esse grão, foi percebido que seus elementos cerosos, localizados na parte cortical, precisam de condições ideais para serem absorvidos, caso contrário podem causar irritação da mucosa (Polese, et al, 2022). O café "desparafinado" é livre desses componentes irritativos e rico nos preventivos, o que ameniza os sintomas negativos e mantém seu efeito benéfico.…”

Section: Dietaunclassified

Abordagens clínicas da doença do refluxo gastroesofágico no âmbito atual: uma revisão de literatura

Araujo,

Dantas,

De Angelo

et al. 2024

Braz. J. Hea. Rev.

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A Doença do Refluxo Gastroesofágico (DRGE) pode ser definida como uma condição na qual o retorno do conteúdo gástrico para o esôfago desencadeia sintomas incômodos e/ou complicações (BARREIRO,B.A e et al., 2023). Ademais, a DRGE é uma das afecções digestivas mais incidentes, cerca de 20% dos adultos nos países ocidentais e aproximadamente 5% dos asiáticos são portadores da doença e a prevalência anual dos sintomas vem aumentando por volta de 4% (BARREIRO, B.A et al., 2023). Logo, este artigo tem como objetivo analisar as abordagens clinicas da doenca do refluxo gastroesofágico no âmbito atual. Dessa forma, este estudo configura-se como uma revisão integrativa realizada por meio do levantamento bibliográfico nos diretórios: Google Scholare Scientific Eletronic LibraryOn-line (SciELO). Desta busca, foram selecionados artigos entre os anos 2021 e 2023, posteriormente submetidos aos critérios de seleção. A doença do refluxo gastroesofágico está associada a uma probabilidade 5 a 7 vezes maior de desenvolver adenocarcinoma esofágico e 60% dos pacientes com câncer relatam história de DRGE. O esôfago de Barrett é uma adaptação metaplásica das células esofágicas em que a mucosa do tipo intestinal substitui a mucosa escamosa normal. Cerca de 15% dos pacientes com DRGE desenvolvem esôfago de Barret. Contínuo a isso, os tratamento mais comuns utilizados na pratica clinica são medidas não farmacológicas como dieta, sono e fitoterapia e farmacológicas como inibidores da bomba de prótons (IBPS), bloqueadores de H2 e procinéticos. Dessa forma, conclui-se que, embora a supressão ácida seja bem-sucedida no tratamento da DRGE, não parece haver uma relação clara entre a gravidade da DRGE e os níveis elevados de ácido gástrico. Ademais, a junção do tratamento farmacológico com o não farmacológico se mostrou superior a abordagem destes de forma isolada.

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Effect of Dewaxed Coffee on Gastroesophageal Symptoms in Patients with GERD: A Randomized Pilot Study

Cited by 9 publications

References 55 publications

The Efficacy of Dietary Interventions in Patients with Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Intervention Studies

The Efficacy of Dietary Interventions in Patients with Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Intervention Studies

Management advice for patients with reflux-like symptoms: an evidence-based consensus

Abordagens clínicas da doença do refluxo gastroesofágico no âmbito atual: uma revisão de literatura

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