Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives

Brutsaert, Tom D.; Soria, Rudy; Caceres, Esperanza; Spielvogel, Hilde; Haas, Jere D.

doi:10.1002/(sici)1520-6300(1999)11:3<383::aid-ajhb9>3.0.co;2-x

Cited by 84 publications

(104 citation statements)

References 21 publications

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“…However, pulmonary function (forced expiratory volume and forced vital capacity) measures were greater in the HA natives compared with the lowland natives born and raised at HAs; this finding suggests a genetic effect. 46 In contrast, these 2 pulmonary measures were similar in HA natives and sea-level natives at lowland; this finding suggests that the genetic potential for larger lung volumes at HA depended on the developmental exposure to HA. In summary, results from these studies emphasized the importance of developmental adaptations to HA.…”

mentioning

confidence: 86%

Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau

Wang

Gong

et al. 2017

AJNR Am J Neuroradiol

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mentioning

confidence: 86%

Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau

Wang

Gong

et al. 2017

AJNR Am J Neuroradiol

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“…However, pulmonary O 2 diffusion capacity can be enhanced further in some high-altitude adapted groups that have larger lungs than lowlanders (Brutsaert et al, 1999;Wu and Kayser, 2006;Brutsaert, 2007;Scott et al, 2010). This is particularly true in birds because their lungs are rigid and are ventilated by air sacs.…”

Section: The Nature Of Physiological Adaptation To High-altitude Hypoxiamentioning

confidence: 99%

Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates

Storz

Scott

Cheviron

2010

Journal of Experimental Biology

346

343

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SummaryHigh-altitude environments provide ideal testing grounds for investigations of mechanism and process in physiological adaptation. In vertebrates, much of our understanding of the acclimatization response to high-altitude hypoxia derives from studies of animal species that are native to lowland environments. Such studies can indicate whether phenotypic plasticity will generally facilitate or impede adaptation to high altitude. Here, we review general mechanisms of physiological acclimatization and genetic adaptation to high-altitude hypoxia in birds and mammals. We evaluate whether the acclimatization response to environmental hypoxia can be regarded generally as a mechanism of adaptive phenotypic plasticity, or whether it might sometimes represent a misdirected response that acts as a hindrance to genetic adaptation. In cases in which the acclimatization response to hypoxia is maladaptive, selection will favor an attenuation of the induced phenotypic change. This can result in a form of cryptic adaptive evolution in which phenotypic similarity between high-and low-altitude populations is attributable to directional selection on genetically based trait variation that offsets environmentally induced changes. The blunted erythropoietic and pulmonary vasoconstriction responses to hypoxia in Tibetan humans and numerous high-altitude birds and mammals provide possible examples of this phenomenon. When lowland animals colonize high-altitude environments, adaptive phenotypic plasticity can mitigate the costs of selection, thereby enhancing prospects for population establishment and persistence. By contrast, maladaptive plasticity has the opposite effect. Thus, insights into the acclimatization response of lowland animals to high-altitude hypoxia can provide a basis for predicting how altitudinal range limits might shift in response to climate change.

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“…Con este estudio se confirman algunas de las premisas expuestas por otros autores sobre la variabilidad de los parámetros de la espirometría entre poblaciones y entre individuos con caracterís-ticas antropométricas y demográficas similares, en especial, respecto a la gran variabilidad del FEF 25%-75% entre hombres de las mismas edades y tallas (44 Estos hallazgos concuerdan con las diferencias encontradas entre poblaciones con características étnicas similares, pero que residen a diferentes altitudes (10,18,19,48,49); los volúmenes pulmonares son mayores en los residentes de altitudes superiores a 2.500 msnm, como es el caso de las poblaciones comparadas. Por ende, también es muy probable que modelos válidos para predecir los parámetros de función pulmonar en la población de Bogotá no sean aplicables a personas residentes en altitudes mayores (3.000 o más msnm).…”

Section: Discussionunclassified

“…Además, se ha encontrado que la ubicación geográfica, la nutrición y la exposición ambiental influyen sobre la función pulmonar (4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

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Valores de referencia para parámetros de espirometría en la población adulta residente en Bogotá, D. C., Colombia

Rojas

Dennis

2010

biomedica

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Nombre de la institución donde se llevó a cabo el trabajo:Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, D.C., ColombiaIntroducción. Los valores de referencia para parámetros de la función pulmonar aplicables a otras poblaciones, han mostrado ser poco válidos en la interpretación de las pruebas de función pulmonar en la población adulta residente en Bogotá. Objetivo. Identificar cuál de cuatro modelos de predicción generados en poblaciones con características étnicas similares a la población colombiana, es el más adecuado para utilizar en adultos de Bogotá. Materiales y métodos. Se reclutaron 534 sujetos de ambos sexos entre los 18 y los 65 años de edad, no fumadores, libres de alteraciones pulmonares, trabajadores de tres empresas privadas y residentes en Bogotá por más de cinco años. La función pulmonar se midió por curva de flujo volumen. Se estimaron las diferencias observadas entre valores predichos y observados, y se calcularon los límites por el método de Bland y Altman. Se aceptaron como válidos los modelos que presentaron un error de predicción promedio máximo de 5% del valor observado en cada parámetro. Resultados. Demostraron ser válidos en esta población los modelos: Crapo para capacidad vital forzada (CVF) en hombres; Pérez-Padilla, para CVF en mujeres y para la relación con el volumen espiratorio forzado en el primer segundo (VEF 1 /CVF) en ambos grupos y los de Hankinson para mexicano-americanos para todos los parámetros en ambos sexos. Conclusiones. Los modelos de Hankinson demostraron ser los más adecuados para predecir todos los parámetros de la espirometría; sin embargo, dejan un porcentaje de mala clasificación promedio de 7%. Se requiere generar modelos propios con mayor precisión pronóstica en la población de Bogotá.Palabras clave: estudios de validación, valores de referencia, pruebas de función respiratoria, modelos lineales, adulto, altitud. Reference values for respiratory parameters in the adult population of Bogotá, D.C., ColombiaIntroduction. Reference values for pulmonary function parameters, generally applicable to most populations, have shown little validity in the correct interpretation of pulmonary function tests when applied to the adult population in Bogotá. Objective. To identify which of four prediction models generated for use in populations of a similar ethnic background to that found in Colombia is the most accurate for use in adults in Bogotá. Materials and methods. 534 subjects (male and female) between 18 and 65 years of age were recruited from a pool of workers employed by three private Bogotá companies. All subjects had resided in Bogotá for at least five years before the initiation of the study. Smokers and those with altered pulmonary function were excluded. Pulmonary function parameters were measured by flow volume curve. The results were analyzed (specifically, the difference between predicted and observed values) and the limits were calculated using the Bland & Altman method. A maximum aver...

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Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives

Cited by 84 publications

References 21 publications

Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau

Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau

Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates

Valores de referencia para parámetros de espirometría en la población adulta residente en Bogotá, D. C., Colombia

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