Effect of detorsion alone and in combination with enoxaparin therapy on ovarian reserve and serum antimüllerian hormone levels in a rat ovarian torsion model

Kaya, Cihan; Turgut, Hürriyet; Cengiz, Hüseyin; Turan, Ayşenur; Ekin, Murat; Yaşar, Levent

doi:10.1016/j.fertnstert.2014.06.007

Cited by 23 publications

(26 citation statements)

References 34 publications

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“…Enzymes such as glutathione peroxidase and catalase play a protective role against cellular ROS. Moreover, cysteine, glutathione, ceruloplasmin, and vitamins A/C/E also act as intracellular and extracellular antioxidants and protect the cell structure from ROS [25]. The balance between oxidants and antioxidants is lost in ischemia-reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model

Karakaş¹,

Kaya²,

Güraslan³

et al. 2020

Turk J Med Sci

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Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods:Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kg metformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated. Results:The total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion and control groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion only group when compared to the metformin+detorsion and control groups (P = 0.001). Conclusion:Metformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.

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Section: Discussionmentioning

confidence: 99%

Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model

Karakaş¹,

Kaya²,

Güraslan³

et al. 2020

Turk J Med Sci

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“…The experimental model of lower limb ischemia of rats was established following the previous study (Iwatsuki, Sakata, Kawasaki, & Okada, 2007). The effects of VEGF over-expressed hUC-MSCs cells transplantation on vascular proliferation and blood perfusion in ischemic skeletal muscle of type 2 diabetic rats were further assessed by morphology, angiography CT and LDPI detection.…”

Section: Discussionmentioning

confidence: 99%

VEGF gene transfected umbilical cord mesenchymal stem cells transplantation improve the lower limb vascular lesions of diabetic rats

Gan

Song

et al. 2015

Journal of Diabetes and its Complications

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“…Assuming that detorsion can provoke this injury and alone is insufficient to protect ovarian reserve as the follicle count decreases (Ozler et al [38]), several agents, including antiinflammatories and antioxidant drugs, have been evaluated to determine whether they have a protective effect [36]. Experimental studies were performed on rat ovaries to demonstrate the role of different drugs in the protection of ovarian function [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. Gradual detorsion can also reduce reperfusion injury in a rat model of ovarian torsion [37].…”

Section: Effects Of Reperfusion After Detorsion: Experimental Studiesmentioning

confidence: 99%

Adnexal torsion in adolescents

Spinelli

Piscioneri

Strambi

2015

Current Opinion in Obstetrics &Amp; Gynecology

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A systematic review of physiopathology, clinical picture, and imaging of adnexal torsion is certainly useful to identify as soon as possible this emergency condition. An early identification and an adequate treatment are indispensable in order to achieve a proper outcome for the patient. The choice of the appropriate surgical approach can be challenging and should be made on the basis of an accurate evaluation of the ovarian lesion. Therefore, it would be useful to perform an intraoperative frozen section analysis in selected cases.

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Effect of detorsion alone and in combination with enoxaparin therapy on ovarian reserve and serum antimüllerian hormone levels in a rat ovarian torsion model

Cited by 23 publications

References 34 publications

Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model

Effect of metformin and detorsion treatment on serum anti-Müllerian hormonelevels and ovarian histopathology in a rat ovarian torsion model

VEGF gene transfected umbilical cord mesenchymal stem cells transplantation improve the lower limb vascular lesions of diabetic rats

Adnexal torsion in adolescents

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