Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function

Varga, Gábor; Kordás, Krisztina; Burghardt, Beáta; Szikora, István; Szénási, Gábor

doi:10.1016/s0014-2999(98)00958-3

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…It has also been reported that deramciclane, a 5‐HT2A‐2C receptor antagonist, and lorglumide, a cholecystokinin A (CCKA) antagonist, cause delayed gastric emptying and decreased gallbladder motility. It is possible that serotonin regulates the effect of CCK primarily via 5‐HT2A receptors in the gastrointestinal tract, including the gallbladder (31). All of these studies suggest that serotoninergic mechanisms affect the gallbladder motility.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Motility in Children With Down Syndrome

Taşdemir,

Çetinkaya,

Polat

et al. 2004

J. pediatr. gastroenterol. nutr.

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Objective:The aim of this study was to investigate gallbladder motility in children with Down syndrome by measuring gall‐bladder volume and contraction index.Methods:This study, performed between January 2001 and December 2002 at the Ondokuz Mayis University, School of Medicine, Department of Paediatric Neurology, Samsun, Turkey, included 21 patients with Down syndrome (study group) and 22 healthy children (control group). After an 8‐hour fast, gallbladder diameters in both groups were measured in length, width, and height by ultrasonography before and 30 minutes after a test meal. The volume of gallbladder before and after a test meal was determined, and the contraction index was calculated. Blood triglyceride and cholesterol levels were measured, and 5‐hydroxyindoleacetic acid (5‐HIAA) levels in urine were determined.Results:Mean gallbladder volume before test meal in the study group and controls was 8,412.4 ± 5,174 mm3 and 16,516.8 ± 6,796.1 mm3 (P < 0.001), respectively. The mean contraction index of the study group was 41.2% ± 19.4% and of controls, 75.0% ± 12.3% (P < 0.001). The mean triglyceride level of the study group was significantly higher than controls (P < 0.05). The mean urine 5‐HIAA level of the study group was lower than controls (P < 0.05).Conclusion:CI was lower in patients with Down syndrome, suggesting gallbladder hypomotility. Hypomotility may be a feature associated with the high prevalence of gallstones in Down syndrome.

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Section: Discussionmentioning

confidence: 99%