Effect of depth on radiation-induced cell damage in a water phantom

Ślosarek, Krzysztof; Konopacka, Maria; Rogoliński, Jacek; Latocha, Małgorzata; Sochanik, Aleksander

doi:10.1016/s1507-1367(05)71080-4

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…However, in contrast to the results reported above our own research demonstrated that in the case of 400 cGy dose a lower dose rate (100 cGy/min) induced more micronuclei and apoptoses in human melanoma (Sk-mel), lung adenocarcinoma (A549), colon cancer (HCT), and normal bronchial epithelial cells (BEAS-2B), as compared to a higher dose rate (600 cGy/min) [ 18 , 19 ]. The dose rate effect was not observed for cells lying outside irradiation area and exposed to scattered radiation dose.…”

Section: Effect Of Dose Rate On Dna Damagecontrasting

confidence: 60%

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Can high dose rates used in cancer radiotherapy change therapeutic effectiveness?

Konopacka¹,

Rogoliński²,

Sochanik³

et al. 2016

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Current cancer radiotherapy relies on increasingly high dose rates of ionising radiation (100–2400 cGy/min). It is possible that changing dose rates is not paralleled by treatment effectiveness.Irradiating cancer cells is assumed to induce molecular alterations that ultimately lead to apoptotic death. Studies comparing the efficacy of radiation-induced DNA damage and apoptotic death in relation to varying dose rates do not provide unequivocal data. Whereas some have demonstrated higher dose rates (single dose) to effectively kill cancer cells, others claim the opposite. Recent gene expression studies in cells subject to variable dose rates stress alterations in molecular signalling, especially in the expression of genes linked to cell survival, immune response, and tumour progression. Novel irradiation techniques of modern cancer treatment do not rely anymore on maintaining absolute constancy of dose rates during radiation emission: instead, timing and exposure areas are regulated temporally and spatially by modulating the dose rate and beam shape. Such conditions may be reflected in tumour cells’ response to irradiation, and this is supported by the references provided.

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Section: Effect Of Dose Rate On Dna Damagecontrasting

confidence: 60%

“…This is not the rule, however. Other studies have demonstrated greater effectiveness of lower dose rates [ 18 – 21 , 25 ]. To fully clarify this ambiguity, it is necessary to perform additional studies examining in depth signaling pathways in cells irradiated with dose rates commonly used in cancer radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Can high dose rates used in cancer radiotherapy change therapeutic effectiveness?

Konopacka¹,

Rogoliński²,

Sochanik³

et al. 2016

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“…In biological point of view, this action defined depth describes the real penetration and not the mathematical one. A good example for this is the effect of X-rays causing apoptosis [40]. The mathematically defined penetration depth of the applied X-ray was around 10 cm, but the apoptosis effect was growing afterward and was active even over 25 cm depths too.…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia Dosing and Depth of Effect

Szász¹,

Peter²,

Vancsik³

et al. 2018

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The penetration depth in the electromagnetic heating could be a crucial factor of its application, when the deep heating is the goal. The capacitive coupling is one of the most popular heating techniques in radiofrequency (RF) heating applications. The matching of the target defines the penetration possibilities. The current matched solution has deeper mathematically defined penetration in RF region than the capacitive plane-wave solution. The same power of application request high voltage with relatively low current for plane-wave inducing, while in current matching it has low voltage with high current. The effective depth of the action in the two solutions do not identical, the penetration defined by the intensity of 1/e portion of the incident beam is higher in the current-matched techniques.

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“…This result has also been confirmed in previous studies. 42 Given that an increase in the depth may change the energy spectrum and the dose rate, the changes in the number of MN can be attributed to the changes in these two factors, i.e. energy spectrum and dose rate, by increasing the depth.…”

Section: Discussionmentioning

confidence: 99%