“…Although physical and psychological factors both produce drug non-persistence, physical dysfunction is not its primary predictor (Dumoulin et al, 2010;Hay-Smith & Dumoulin, 2006), contrasting with psychological variables (e.g., depression, anxiety) that play key roles (Goode et al, 2008;Khan et al, 2013;Osborne et al, 2016). Although development of β3-adrenoceptor agonists, that have fewer side effects, helps overcome the problems associated with older antimuscarinic drugs (Thiagamoorthy et al, 2016), such an Hypnotherapy for OAB -4 approach does not address the psychological factors that can determine therapy nonadherence (DiMatteo et al, 2000).…”