Effect of depletion of L3T4+ cells on resistance to early primary infection of mice with Taenia taeniaeformis

Davis, S. W.; Hammerberg, Bruce

doi:10.1016/0020-7519(90)90116-5

Cited by 3 publications

(9 citation statements)

References 18 publications

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“…Initial 10 d of response in (resistant) Balb/c mice . Initial 15 d of response in (resistant) C57 mice …”

Section: A Tentative General Model Of Host Tissue Responses In Larvalmentioning

confidence: 99%

“…Thus, granuloma formation (including fibrosis) in response to E. multilocularis infection is essentially absent in mice lacking lymphocytes or more specifically lacking the TCRβ chain, or deficient in MHCII . In terms of early responses, the protective eosinophil and macrophage infiltration observed in resistant mice challenged with T. taeniaeformis up to 6 dpi depends on CD4 + T cells …”

Section: What Signals and Processes Shape Tissue Responses To Larval mentioning

confidence: 99%

“…Resistance mechanisms against effectors include the barrier function of the Echinococcus LL and possibly the early “perilarval amorphous material” apparently deployed by establishing T. taeniaeformis larvae …”

Section: How Do Larval Taeniids Evade Granulomatous Responses?mentioning

confidence: 99%

“…In susceptible mouse strains (C3H), infiltration tends to be mild, and in particular, eosinophils are absent; in addition, inflammatory cells are prevented from touching the parasite by an acellular "halo" or "perilarval amorphous material" said to resemble the Echinococcus LL. [38][39][40] In contrast, in resistant mouse strains (Balb/c), eosinophils gain access to the interior of the "halo" by 5 dpi, and by 10-13 dpi, the parasite is destroyed. 38,40,41 Strikingly, the parasite appears to be reabsorbed so that no granuloma or scar remains by 17 dpi.…”

Section: Taenia Taeniaeformismentioning

confidence: 99%

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Granulomatous responses in larval taeniid infections

Díaz

Sagasti

Casaravilla

2018

Parasite Immunology

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Granulomas are responses to persistent nonliving bodies or pathogens, centrally featuring specialized macrophage forms called epithelioid and multinucleated giant cells. The larval stages of the cestode parasites of the Taeniidae family (Taenia, Echinococcus) develop for years in fixed tissue sites in mammals. In consequence, they are targets of granulomatous responses. The information on tissue responses to larval taeniids is fragmented among host and parasite species and scattered over many decades. We attempt to draw an integrated picture of these responses in solid tissues. The intensity of inflammation around live parasites spans a spectrum from minimal to high, parasite vitality correlating with low inflammation. The low end of the inflammatory spectrum features collagen capsules proximal to the parasites and moderate distal infiltration. The middle of the spectrum is dominated by classical granulomatous responses, whereas the high end features massive eosinophil invasions. Across the range of parasite species, much observational evidence suggests that eosinophils are highly effective at killing larval taeniids in solid tissues, before and during chronic granulomatous responses. The evidence available also suggests that these parasites are adapted to inhibit host granulomatous responses, in part through the exacerbation of host regulatory mechanisms including regulatory T cells and TGF-β.

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“…Initial 10 d of response in (resistant) Balb/c mice . Initial 15 d of response in (resistant) C57 mice …”

Section: A Tentative General Model Of Host Tissue Responses In Larvalmentioning

confidence: 99%

Section: What Signals and Processes Shape Tissue Responses To Larval mentioning

confidence: 99%

Section: How Do Larval Taeniids Evade Granulomatous Responses?mentioning

confidence: 99%

Section: Taenia Taeniaeformismentioning

confidence: 99%

See 2 more Smart Citations

Granulomatous responses in larval taeniid infections

Díaz

Sagasti

Casaravilla

2018

Parasite Immunology

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“…It has been known that the mechanisms include humoral factors, i.e. an tibody [1], complement [2] and cellular factors like CD4+ lymphocytes, eosinophils [3] or macrophages [4].…”

Section: Introductionmentioning

confidence: 99%

Participation of Platelets in Protection against Larval <i>Taenia taeniaeformis</i> Infection in Mice

Kakuda¹,

Ooi²,

Oku³

et al. 1996

Int Arch Allergy Immunol

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Responses to larvalTaenia taeniaeformisin mice with severe combined immunodeficiency (scid)

et al. 1992

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Responses to Taenia taeniaeformis infection were studied in mice with severe combined immunodeficiency (scid), which lack functional T and B lymphocytes. In the early phase of infection, accumulation of polymorphonuclear leucocytes (PML) occurred around the larvae in the liver of scid mice and their immunocompetent counterparts, C.B-17, (a BALB/c strain, genetically resistant to this parasite). PML accumulation continued until encapsulation of developing larvae by fibroblasts (14 days p.i.), and subsequent fibrosis resulted in granuloma formation. No infiltration of eosinophils or macrophages around larvae was observed in scid mice prior to granuloma formation, while in C.B-17 mice infiltration was observed as early as 5 days p.i., when specific antibodies could not be detected in the circulation. Most larvae were destroyed by 14 days p.i. in C.B-17 mice. In scid mice the larvae survived but the host capsules (cysts) were thin and most contained blood at 42 days p.i. In these cysts, inflammatory cells were observed on the larval surface and in invaded parasite tissue. Hepatocyte coagulation necrosis adjacent to larvae was commonly found in C.B-17 mice by 5 days p.i., while it did not occur in scid mice throughout these experiments. These results suggest that in host responses to larval T. taeniaeformis, PML accumulation and encapsulation by fibrosis are T and B cell independent, while eosinophil and macrophage infiltration, as well as resistance to infection, are T and/or B cell dependent. Additionally, there may be an association between host cell necrosis around larvae and T and/or B cell responses.

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Effect of depletion of L3T4+ cells on resistance to early primary infection of mice with Taenia taeniaeformis

Cited by 3 publications

References 18 publications

Granulomatous responses in larval taeniid infections

Granulomatous responses in larval taeniid infections

Participation of Platelets in Protection against Larval <i>Taenia taeniaeformis</i> Infection in Mice

Responses to larvalTaenia taeniaeformisin mice with severe combined immunodeficiency (scid)

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