Effect of Demineralizing Agents on Organic and Inorganic Components of Dentine

Miller, Cheryl A.; Ashworth, Eleanor; Deery, Chris; Sharkasi, Lamis El; Moorehead, Robert; Martín, Nicolás

doi:10.1159/000518463

Cited by 4 publications

(1 citation statement)

References 46 publications

(48 reference statements)

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“…This dissolution or demineralization of the dentin is possible due to its decreased total mineral content. Several chemical treatments have been shown to demineralize dentin and these include ethylenediamine tetraacetic acid (EDTA), hydrochloric acid (HCl) and nitric acid ( Miller et al, 2021 ). The method of demineralization, including chemicals used and duration of treatment, impacts the structure of the organic matrix which remains, and this affects the regenerative potential of the demineralized dentin matrix (DDM) generated.…”

Section: Introductionmentioning

confidence: 99%

Demineralized dentin matrix for bone regeneration in dentistry: A critical update

Khurshid,

Adanir,

Ratnayake

et al. 2024

The Saudi Dental Journal

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Section: Introductionmentioning

confidence: 99%

Demineralized dentin matrix for bone regeneration in dentistry: A critical update

Khurshid,

Adanir,

Ratnayake

et al. 2024

The Saudi Dental Journal

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Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review

Grawish

et al. 2022

Tissue Eng Regen Med

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Background: Dentin is a permeable tubular composite and complex structure, and in weight, it is composed of 20% organic matrix, 10% water, and 70% hydroxyapatite crystalline matrix. Demineralization of dentin with gradient concentrations of ethylene diamine tetraacetic acid, 0.6 N hydrochloric acid, or 2% nitric acid removes a major part of the crystalline apatite and maintains a majority of collagen type I and non-collagenous proteins, which creates an osteoinductive scaffold containing numerous matrix elements and growth factors. Therefore, demineralized dentin should be considered as an excellent naturally-derived bioactive material to enhance dental and alveolar bone tissues regeneration. Method: The PubMed and Midline databases were searched in October 2021 for the relevant articles on treated dentin matrix (TDM)/demineralized dentin matrix (DDM) and their potential roles in tissue regeneration. Results: Several studies with different study designs evaluating the effect of TDM/DDM on dental and bone tissues regeneration were found. TDM/DDM was obtained from human or animal sources and processed in different forms (particles, liquid extract, hydrogel, and paste) and different shapes (sheets, slices, disc-shaped, root-shaped, and barrier membranes), with variable sizes measured in micrometers or millimeters, demineralized with different protocols regarding the concentration of demineralizing agents and exposure time, and then sterilized and preserved with different techniques. In the act of biomimetic acellular material, TDM/DDM was used for the regeneration of the dentin-pulp complex through direct pulp capping technique, and it was found to possess the ability to activate the odontogenic differentiation of stem cells resident in the pulp tissues and induce reparative dentin formation. TDM/DDM was also considered for alveolar ridge and maxillary sinus floor augmentations, socket preservation, furcation perforation repair, guided bone, and bioroot regenerations as well as bone and cartilage healing. Conclusion: To our knowledge, there are no standard procedures to adopt a specific form for a specific purpose; therefore, future studies are required to come up with a well-characterized TDM/DDM for each specific application. Likely as decellularized dermal matrix and prospectively, if the TDM/DDM is supplied in proper consistency, forms, and in different sizes with good biological properties, it can be used efficiently instead of some widely-used regenerative biomaterials.

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A glycol chitosan derivative with extrafibrillar demineralization potential for self-etch dentin bonding

Li,

Qiu,

Wang

et al. 2024

Dental Materials

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Effect of Demineralizing Agents on Organic and Inorganic Components of Dentine

Abstract: This is a repository copy of Effect of demineralising agents on organic and inorganic components of dentine.

Cited by 4 publications

References 46 publications

Demineralized dentin matrix for bone regeneration in dentistry: A critical update

Demineralized dentin matrix for bone regeneration in dentistry: A critical update

Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review

A glycol chitosan derivative with extrafibrillar demineralization potential for self-etch dentin bonding

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