Effect of dehydroepiandrosterone sulfate on interleukin-8 receptor during cervical ripening

Kanayama, Naohiro; Maradny, Emad El; Goto, Junko; Terao, Toshihiko

doi:10.1530/eje.0.1380587

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Numerous human and animal studies have explored the role of androgens in the cervix, particularly during pregnancy (Mochizuki et al , 1978a, b; Sasaki et al , 1982; Mochizuki and Maruo, 1985; Takahashi et al , 1984; Sakyo et al , 1986, 1987; Yamashita et al , 1991; El Maradny et al , 1996; Kanayama et al , 1998; Ji et al , 2008). These studies formed the basis of a hypothesis, whereby androgens regulate cervical remodelling, particularly CR at term.…”

Section: Resultsmentioning

confidence: 99%

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Androgens in pregnancy: roles in parturition

Makieva

Saunders

Norman

2014

Human Reproduction Update

179

143

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BACKGROUNDUnderstanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterus (i) retains the fetus in utero during pregnancy without initiating stretch-induced contractions and (ii) is able to dilate the cervix and contract the myometrium at term to deliver the fetus. The onset of labour is associated with successful cervical remodelling and contraction of myometrium, arising from concomitant activation of uterine immune and endocrine systems. A large body of evidence suggests that actions of local steroid hormones may drive changes occurring in the uterine microenvironment at term. Although there have been a number of studies considering the potential role(s) played by progesterone and estrogen at the time of parturition, the bio-availability and effects of androgens during pregnancy have received less scrutiny. The aim of this review is to highlight potential roles of androgens in the biology of pregnancy and parturition.METHODSA review of published literature was performed to address (i) androgen concentrations, including biosynthesis and clearance, in maternal and fetal compartments throughout gestation, (ii) associations of androgen concentrations with adverse pregnancy outcomes, (iii) the role of androgens in the physiology of cervical remodelling and finally (iv) the role of androgens in the physiology of myometrial function including any impact on contractility.RESULTSSome, but not all, androgens increase throughout gestation in maternal circulation. The effects of this increase are not fully understood; however, evidence suggests that increased androgens might regulate key processes during pregnancy and parturition. For example, androgens are believed to be critical for cervical remodelling at term, in particular cervical ripening, via regulation of cervical collagen fibril organization. Additionally, a number of studies highlight potential roles for androgens in myometrial relaxation via non-genomic, AR-independent pathways critical for the pregnancy reaching term. Understanding of the molecular events leading to myometrial relaxation is an important step towards development of novel targeted tocolytic drugs.CONCLUSIONSThe increase in androgen levels throughout gestation is likely to be important for establishment and maintenance of pregnancy and initiation of parturition. Further investigation of the underlying mechanisms of androgen action on cervical remodelling and myometrial contractility is needed. The insights gained may facilitate the development of new therapeutic approaches to manage pregnancy complications such as preterm birth.

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Section: Resultsmentioning

confidence: 99%

“…Indeed, DHEAS action on CR has been correlated with increased levels of IL-8 cytokine involved in chemotaxis of neutrophils recruited in cervix towards term (Kanayama et al , 1998; Maymon et al , 2000). …”

Section: Resultsmentioning

confidence: 99%

Androgens in pregnancy: roles in parturition

Makieva

Saunders

Norman

2014

Human Reproduction Update

179

143

View full text Add to dashboard Cite

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“…This shows that DHEA-S might have a synergistic effect on IL-8 action. Additionally, it was shown that DHEA-S can stimulate the expression of IL-8 and IL-8 receptors and enhance HA production in the cervical stroma [ 107 , 108 ]. As mentioned before, HA is a strong IL-8 synthesis stimulator.…”

Section: Regulation Of Cervical Ripeningmentioning

confidence: 99%

Signaling Pathways Regulating Human Cervical Ripening in Preterm and Term Delivery

Socha

Flis²,

Pietrus

et al. 2022

Cells

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At the end of gestation, the cervical tissue changes profoundly. As a result of these changes, the uterine cervix becomes soft and vulnerable to dilation. The process occurring in the cervical tissue can be described as cervical ripening. The ripening is a process derivative of enzymatic breakdown and inflammatory response. Therefore, it is apparent that cervical remodeling is a derivative of the reactions mediated by multiple factors such as hormones, prostaglandins, nitric oxide, and inflammatory cytokines. However, despite the research carried out over the years, the cellular pathways responsible for regulating this process are still poorly understood. A comprehensive understanding of the entire process of cervical ripening seems crucial in the context of labor induction. Greater knowledge could provide us with the means to help women who suffer from dysfunctional labor. The overall objective of this review is to present the current understanding of cervical ripening in terms of molecular regulation and cell signaling.

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“…Among steroid hormones that influence remodeling of uterine cervix, dehydroepiandrosterone sulphate (DHEA‐S), and dihydrotestosterone (DHT) stand out 7 . DHEA‐S has role in activation of neutrophils and macrophages, that is, it stimulates activation of the proteolytic enzymes in uterine cervix 8–10 . Progesterone (P4), DHT, dehydroepiandrosterone (DHEA), and DHEA‐S on the other side, make impact on the uterine contractility 11 …”

Section: Introductionmentioning

confidence: 99%

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

Kadivnik

Debeljak

Mandić

et al. 2021

J of Obstet and Gynaecol

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Aim The aim of research was to evaluate the maternal serum concentration of selected endogenous steroid hormones during spontaneous parturition at term and to determinate their association with the need for oxytocin augmentation. Methods Blood of 108 healthy pregnant women whose parturition started with the regular spontaneous uterine contractions was drawn at the beginning of the labor. Liquid chromatography coupled to the tandem mass spectrometry device was utilized for measurement of sex hormone binding globulin, aldosterone, androstenedione, cortisol, cortisone, corticosterone, dehydroepiandrosterone, dehydroepiandrosteron sulphate, 17‐hydroxyprogesterone, progesterone, and testosterone. Mann–Whitney U test, chi‐square test, univariate and multivariate logistic regression, and receiver operating characteristic (ROC) analysis were used for the data analysis. Results Reference ranges of the selected hormones assessed by liquid chromatography coupled to the tandem mass spectrometry in maternal serum were established. Statistically significant differences in the serum concentration of corticosterone, dehydroepiandrosterone, and androstenedione between mothers requiring oxytocin augmentation and the rest of women having spontaneous parturition were found (p = 0.002, p = 0.008, and p = 0.04, respectively). Concentrations were lower in the group of mothers who required oxytocin infusion for progression of labor. ROC analysis showed that all the mothers with dehydroepiandrosterone serum concentration above 21.6 nmol/L have lower chance to use oxytocin infusion for the labor progression ( area under the curve (AUC) = 0.649, sensitivity = 71.7%, specificity = 59.6%, p = 0.006). Conclusion This research provided reference ranges for the selected maternal serum steroid hormones at the beginning of parturition. Association of corticosterone, dehydroepiandrosterone, and androstenedione with the need for the oxytocin infusion usage has been established. Dehydroepiandrosterone could be potential predictor of oxytocin infusion augmentation for progression of the parturition.

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Effect of dehydroepiandrosterone sulfate on interleukin-8 receptor during cervical ripening

Cited by 9 publications

References 24 publications

Androgens in pregnancy: roles in parturition

Androgens in pregnancy: roles in parturition

Signaling Pathways Regulating Human Cervical Ripening in Preterm and Term Delivery

Requirement for oxytocin augmentation in spontaneous parturition is associated with the maternal serum steroid hormones assessed by liquid chromatography coupled to the tandem mass spectrometry

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