Effect of Defibrotide in Electrically Induced Thrombosis in Dogs

Abstract

Thrombi were electrically induced in dogs. The alterations of the vessel wall were studied in samples obtained on the 8th day from control and treated animals. Changes in coagulation parameters were monitored daily. Animals were treated with 600 mg defibrotide (Crinos) daily for a week, starting 24 h after the induction of thrombi. In the control dogs there was thickening of intima with endothelial hyperplasia and smooth muscle proliferation. The treated animals did not show any morphological or ultrastructural alterations (SEM). This observation encourages us to examine the role of fibrinolytic and endothelial supportive therapy for prevention of development of vascular changes.

Pharmacologic Intervention to Prevent Hemodialysis Vascular Access Thrombosis

“…Moreover, it may promote another endothelial function, that of fibrinolysis. Initially, it was shown to reduce intimal hyperplasia after thrombi were electrically induced in dogs [131]. In humans, II it has reduced the incidence of intimal hyperplasia in renal transplant grafts [132] and prevented thrombosis of subcla vian catheter use for total parenteral nutrition [133] and reversed the acute renal failure associated with endothelial injury in hemolytic uremic syndrome and thrombotic thrombocytopenic purpura [134].…”

Effects of Defibrotide on Peripheral Obliterative Vascular Diseases

“…1983/84]. The activating effect of defibrotide on the release of t-PA and PGI2 from endo thelial cells plays an important role in this antithrombotic response [2,10]. Although it is early to say, our experimental observa tions, and clinical results suggest that defi brotide modifies and repairs the impaired vessel wall, especially endothelial cell func tion.…”

Atherosclerosis and Hemostasis

“…I would like to summarize our results with the new substance Defibrotide: 87,177, [233][234][235][236][237][238] Defibro- tide is a polydeoxyribonucleotide that is obtained from mammalian tissues by extraction. In animals it had a profibrinolytic and antithrombotic effect.…”