Effect of Deep Brain Stimulation in Rats Selectively Bred for Reduced Prepulse Inhibition

Angelov, Svilen; Dietrich, Carolin; Krauss, Joachim K.; Schwabe, Kerstin

doi:10.1016/j.brs.2014.03.013

Cited by 18 publications

(17 citation statements)

References 56 publications

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“…These findings extend previous observations as we have recently demonstrated that mPFC-DBS transiently improved PPI in the adult offspring of poly I:C dams (Klein et al, 2013). Ma and Leung (2014) found that rats given stimulation to the Nacc at 130 Hz had an attenuation in ketamine-induced PPI deficits and hyper-locomotion, while Angelov and colleagues found that Nacc DBS was not effective in rats with breeding-induced low PPI (Angelov et al, 2014). When considered in light of our present data, these findings suggest that mPFC and Nacc may be a suitable DBS targets for schizophrenia-like behavior.…”

Section: Discussionsupporting

confidence: 75%

Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

Bikovsky

Hadar

Soto-Montenegro

et al. 2016

Experimental Neurology

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Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not adequately responding to treatment. Deep brain stimulation (DBS) is a surgical technique currently investigated for medically-refractory psychiatric disorders. Here, we use the poly I:C rat model of schizophrenia to study the effects of medial prefrontal cortex (mPFC) and nucleus accumbens (Nacc) DBS on two behavioral schizophrenia-like deficits, i.e. sensorimotor gating, as reflected by disrupted prepulse inhibition (PPI), and attentional selectivity, as reflected by disrupted latent inhibition (LI). In addition, the neurocircuitry influenced by DBS was studied using FDG PET. We found that mPFC-and Nacc-DBS alleviated PPI and LI abnormalities in poly I:C offspring, whereas Nacc-but not mPFC-DBS disrupted PPI and LI in saline offspring. In saline offspring, mPFC-DBS increased metabolism in the parietal cortex, striatum, ventral hippocampus and Nacc, while reducing it in the brainstem, cerebellum, hypothalamus and periaqueductal gray. Nacc-DBS, on the other hand, increased activity in the ventral hippocampus CIHR Author Manuscript CIHR Author Manuscript CIHR Author Manuscriptand olfactory bulb and reduced it in the septal area, brainstem, periaqueductal gray and hypothalamus. In poly I:C offspring changes in metabolism following mPFC-DBS were similar to those recorded in saline offspring, except for a reduced activity in the brainstem and hypothalamus. In contrast, Nacc-DBS did not induce any statistical changes in brain metabolism in poly I:C offspring. Our study shows that mPFC-or Nacc-DBS delivered to the adult progeny of poly I:C treated dams improves deficits in PPI and LI. Despite common behavioral responses, stimulation in the two targets induced different metabolic effects.

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Section: Discussionsupporting

confidence: 75%

Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

Bikovsky

Hadar

Soto-Montenegro

et al. 2016

Experimental Neurology

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“…Also, in our second measurement following surgery we found higher levels of anhedonia in FSL sham-stimulated rats as compared to sham-stimulated controls. The mere implantation of electrodes did not affect the level of anhedonia in FSL and controls suggesting that micro lesion effects previously shown to be involved in early postoperative outcome are not applicable here [59,60]. Most importantly, we found that MFB-DBS selectively modulated the hedonic state in FSL but not control rats.…”

Section: Mfb-dbs Reduces Anhedonia-like Behaviorcontrasting

confidence: 50%

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

et al. 2015

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“…Kohl et al, 2015) of these disorders, often engaging a range of cross-species models of PPI in the process (e.g. Angelov et al, 2014; Baldan Ramsey et al, 2011; Brooks et al., 2012; Carter et al, 1999; Shilling et al, 2008). The role of psychotropic medications and other demographic and clinical variables in some of these clinical phenotypes has also been tested in many reports (e.g.…”

Section: Theme 1: Ppi Is Impaired Across Categorically Distinct Neuromentioning

confidence: 99%

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

2016

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Our 1992 paper, ‘The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications’, reviewed a series of (then) new and preliminary findings from cross-species studies of prepulse inhibition of the startle reflex, and commented on their implications. At the time that the report was composed, PubMed listed about 40 citations for studies using the search term ‘prepulse inhibition’. In the ensuing 25 years, the field has added about 2700 such reports, reflecting the substantial growth in interest in prepulse inhibition and its utility across a number of different experimental applications. The 30th anniversary of the Journal of Psychopharmacology provides an opportunity to comment briefly on what was described in that 1992 report, how the field has progressed in the subsequent decades, and the paths forward for studies of prepulse inhibition and its use as an operational measure of sensorimotor gating. Among these future paths, we highlight the use of prepulse inhibition as: an endophenotype for genomic studies, and a biomarker for healthy brain circuitry, which may predict sensitivity to psychotherapeutics. Our 1992 report was highly speculative and based on paper-thin empirical data, yet viewed in a certain light, it appears to have contained a basic roadmap for a journey spanning the next 25 years of prepulse inhibition research… and ‘what a long, strange trip it’s been’.

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Effect of Deep Brain Stimulation in Rats Selectively Bred for Reduced Prepulse Inhibition

Cited by 18 publications

References 56 publications

Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

Deep brain stimulation improves behavior and modulates neural circuits in a rodent model of schizophrenia

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

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