Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats

Chae, Jung-Woo; Baek, In‐hwan; Kwon, Kwang‐il

doi:10.1016/j.jep.2012.08.046

Cited by 12 publications

(6 citation statements)

References 33 publications

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“…Enoxacin and fluvoxamine are strong inhibitors of CYP1A2, and their activities were previously reported in an in vivo drug-interaction, where enoxacin was an inhibitor of CYP1A2 and fluvoxamine was a substrate (Kunii et al, 2005). Decursin, used as a traditional Asian medicine for examining the pharmacokinetics of theophylline in rats, is a typical substrate of CYP1A2 enzyme (Chae et al, 2012). The CYP2C subfamily is one of 12 CYP subfamilies in humans, which consist of four isoforms, namely CYP2C8, CYP2C9, CYP2C18, and CYP2C19, which metabolize about 25% of clinical drugs and share >82% sequence homology (Totah and Rettie, 2005;Xiaoping et al, 2013).…”

Section: Resultsmentioning

confidence: 92%

In vitro inhibition of human cytochrome P450 by cudratricusxanthone A

Sim

Choi

Lee

et al. 2015

Food and Chemical Toxicology

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Section: Resultsmentioning

confidence: 92%

In vitro inhibition of human cytochrome P450 by cudratricusxanthone A

Sim

Choi

Lee

et al. 2015

Food and Chemical Toxicology

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“…From days 15 to 25, the rats were challenged on 10 consecutive days with the administration of 1 mg/mL or 2% OVA inhalation, 30 min/day. The normal control group received the same volume of saline subcutaneously (days 8 and 15) and inhalation (days [15][16][17][18][19][20][21][22][23][24][25].…”

Section: Grouping and The Asthma Modelmentioning

confidence: 99%

“…NF-κB activation is also closely associated with airway tissue remodeling (fibrosis of surrounding airway tissues, hyperplasia and hypertrophy of smooth muscle cells, and myxogenesis) (14). When asthmatics have airway inflammation and hyperresponsiveness, NF-κB and its inflammatory factors can reduce the metabolic clearance activity of theophylline and increase the incidence of theophylline accumulation toxicity, which is more likely to occur in children and elderly patients (15,16). NF-κB, a key factor in the inflammatory process, regulates the gene expression of cytochrome P450 3A (CYP3A) through the pregnane X receptor (PXR), thereby affecting drug metabolism (17).…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal component, Praeruptorin E, enhances anti-asthma efficacy and prevents toxicity of aminophylline by targeting the NF-κB/PXR/CYP3A4 pathway

Xu¹,

Deng²,

Gan³

et al. 2022

Ann Transl Med

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Background: Aminophylline is widely used for the treatment of asthma, but the therapeutic dose is very close to the toxic dose, which makes this drug prone to accumulation poisoning. In the present study, we explored whether the Chinese herbal component, Praeruptorin E (PE), enhances anti-asthma efficacy and prevents the toxicity of aminophylline.Methods: First, an ovalbumin (OVA)-induced mouse model of asthma, immunohistochemistry, pathological staining, and bronchoalveolar lavage fluid (BALF) were used to detect the lung condition of asthmatic mice. The content of Th2 cytokines in serum was measured by enzyme-linked immunosorbent assay (ELISA), and the expression of related proteins was detected by Western blotting and immunofluorescence.Concentrations of theophylline and its metabolites in rat serum were analyzed by liquid chromatographytandem mass spectrometry (LC-MS/MS). siRNA transfection and chromatin immunoprecipitation (ChIP) were used to investigate the mechanism of PE.Results: PE was found to synergize with aminophylline to reduce the infiltration of inflammatory cells, collagen deposition, and mucus hyperplasia in the lungs of asthmatic mice. It inhibited the expression of Th2 cytokines, interleukin (IL)-4, IL-5, and IL-13; promoted lung tissue repair; and reduced the toxic effect of aminophylline on the heart. Moreover, LC-MS/MS analysis showed that PE reduced the plasma concentration of the parent theophylline and its metabolite 1,3-dimethyluric acid (1,3-DMU). PE facilitated aminophylline's suppression of nuclear factor-κB (NF-κB), and increased the expression of the xenobiotic nuclear receptor pregnane X receptor (PXR) and its primary target gene, CYP3A11

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“…Three different Angelica species have been recorded to contain the most active principle, decursin 44 . Decursin, has various pharmacological properties, including anticancer, anti-bacterial, platelet aggregation inhibitor and anti-inflammatory effects 45 . A study has pointed out that decursin suppressed the activities of CYP1A2, CYP2D15, and CYP3A12 in canine liver microsomes 46 .…”

Section: Angelica Speciesmentioning

confidence: 99%

“…So, chronic use of decursin with TPH concomitantly could elevate the concentration of TPH in the blood. There are suggestions about the interaction of decursin with CYP1A2 substrates 45 .…”

Section: Angelica Speciesmentioning

confidence: 99%

A Review of Theophylline's Pharmacological Interactions With Medicinal Herbs

Abushammala

Hamdan²

2022

Bulletin of Pharmaceutical Sciences. Assiut

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Theophylline (TPH) is a bronchodilator with a limited therapeutic index and high interindividual pharmacokinetic (PK) variability. In this paper, the interactions between TPH and medicinal herbs recorded in the literature were summarized. The collected references in the analyzed literature were investigated. A decrease in TPH bioavailability by induction mechanism on CYP1A2 was reported during co-administration of herbs or herbal extracts as (Andrographis paniculata, Commiphora myrrha, Ephedra species, Evodia rutaecarpa, Lepidium sativum, Sophora flavescens, Salvia miltiorrhiza, and Trigonella foenum-graecum). TPH bioavailability was increased by inhibition mechanism on CYP1A2 when co-administered with herbs (Acacia catechu, Angelica species, Astragalus species, Cassia auriculata, Cardiospermum halicacabum and Scutellariae baicalensis. Meanwhile, concomitant use of TPH with (Cassia occidentalis, Glycyrrhiza glabra, Ginkgo biloba, Hypericum perforatum, Nigella sativa, Punica granatum and Rhodiola rosea) was reported to be insignificant. In this review, we focus on the interactions between TPH and medicinal herbs that haven't been covered in prior studies. To reduce the patients' health risks, health professionals involved in their treatment are expected to be thoroughly educated about the interactions between TPH and medicinal plants.

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Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats

Cited by 12 publications

References 33 publications

In vitro inhibition of human cytochrome P450 by cudratricusxanthone A

In vitro inhibition of human cytochrome P450 by cudratricusxanthone A

Chinese herbal component, Praeruptorin E, enhances anti-asthma efficacy and prevents toxicity of aminophylline by targeting the NF-κB/PXR/CYP3A4 pathway

A Review of Theophylline's Pharmacological Interactions With Medicinal Herbs

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