Effect of DDT on the reproductive life-span in the female rat

Studies on Implantation and Embryonic Development in Mice Given a Highly Chlorinated Hexadecane

“…The significantly increased conception rate is notable, although difficult to explain. A positive effect of a xenobiotic on the reproductive capacity has previously been observed by Ottoboni (1972), who reported an increased reproductive life-span in rats exposed to DDT. A few embryonic malformations were seen during this study, but they were evenly distributed among the two treatment groups.…”

Endocrine Disruptors Are a Novel Direction of Endocrinologic Scientific Investigation

“…При вве-дении ДДТ в дозах, оказывающих гонадотропное влияние на семенники петушков, крыс, многие из них погибли уже в первый день эксперимента [16]. А. Ottoboni показал, что репродуктивная функция у самок крыс остается нор-мальной при скармливании им ДДТ в концентрации 10 мг/кг в день в двух поколениях, а при концентрации ДДТ 20 мг/кг имеет место значительное увеличение репродуктивного периода [18]. Эти данные дают осно-вание полагать, что ДДТ не только стимулирует эстро-генную функцию яичников и коры надпочечников, но и пролонгирует ее.…”

Untitled

“…DDT [1,I-bis(p-chlorophenyl)-2,2,2-trichloroethaneJ Until recently, DDT has been the most widely used of the synthetic organochlorine pesticides. Numerous studies of the effect of DDT on rodent reproduction have been reported (3)(4)(5)(6)(7). Burlington & Lindeman (8) were probably the first to report the inhibition of testicular growth and development of secondary sex char acteristics in white Leghorn cockerels.…”