Effect of DDT on reproduction in the rat

Ottoboni, Alice

doi:10.1016/0041-008x(69)90166-5

Cited by 51 publications

(5 citation statements)

References 7 publications

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“…Therefore, certain DDT homologs may hasten the process o f reproductive aging, i.e., the development of PVE and anovulation. These results may be contrasted with those of Ottoboni [17] who suggests that DDT feedings may protect against reproductive aging by slightly increasing fertility in older rats. The reasons for this discrepancy cannot be explained because of differences in the experimental designs.…”

Section: Discussioncontrasting

confidence: 74%

Effects of DDT Homologs Administered to Female Rats during the Perinatal Period

Rj¹,

Wl²

1975

Neonatology

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The administration of estrogen to female rats during the perinatal period induces a masculine pattern of hypothalamic differentiation resulting in persistent vaginal estrus (PVE) and anovulation. 10 mg day of the estrogenic homologs op′-DDT, op′-DOE, and DDA, as well as allegedly nonestrogenic forms of the pesticide, pp′-DDT and op′-DDD, were given by gavage from days 15–19 of pregnancy. 1-mg doses of the homologs were also given SQ daily to female rats on the second, third, and fourth days of life. Vaginal opening was delayed by 2 days in rats derived from the dams gavaged with o,p′-DDD. Periodic examination of estrous cycles in the rats treated neonatally with op′-DDD revealed PVE by 209 days of age, and absence of corpora lutea by 258 days of age. Prior to 4 months of age, estrous cycles were normal in these animals. The remaining pesticide homologs tested, regardless of the mode of administration, had no significant effect on the estrous cycles or on endocrine gland weights.

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Section: Discussioncontrasting

confidence: 74%

Effects of DDT Homologs Administered to Female Rats during the Perinatal Period

Rj¹,

Wl²

1975

Neonatology

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“…The experiments on rats fed a diet containing 2.4 ppm (Feaster et al, 1972) or 20 and 200 ppm (Ottoboni, 1969) showed no effect on fecundity.…”

Section: Insecticides 177mentioning

confidence: 86%

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

Moutschen-Dahmen

Degraeve

1984

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

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“…Although there have been no reports of teratogenic effects from DDT, with the possible exception of ringtail in rats (Ottoboni 1969), DDT has consistently resulted in decreased fertility in mice (Keplingler et al,. 1968, McLachlan and Dixon 1972, Schmidt 1973; however, conflicting results have been reported in rats (Fitzhugh and Nelson 1947, Fitzhugh 1948, Treon and Cleveland 1955, Clement and Okey 1974, Jonsson et al,.…”

Section: Teratogenicitymentioning

confidence: 99%