Effect of Ddavp on Contact Phase of Blood Coagulation

Vicente, Vicente; Alberca, I; Calles, Marcel; Borrasca, A. López

doi:10.1111/j.1365-2141.1984.tb02192.x

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The effect of DDAVP on the factor XIIdependent pathway of plasminogen activa tion was examined since this was controver sial [30,31]. In the present study, plasma levels of factor XII, kallikrein and plasmin were not significantly affected by intranasal DDAVP treatment.…”

Section: Discussionmentioning

confidence: 52%

“…Although other factors might partly account for the reduced clotting protein levels, as circadian changes [28] and/or repeated blood sampling [29], the in creased fibrinopeptide A values, however, suggest that limited phenomena of intravas cular coagulation have occurred with subse quent clotting factor consumption. Endo toxin contaminants [30,31] The possibility that intravascular clotting and consumption coagulopathy may account for the clotting changes found during L-Asp therapy has been much debated in previous studies with widely discordant conclusions [7,35]. The difference in results may again have been caused by the study design, pa tients investigated, and phase of the disease and dosage schedules.…”

Section: Discussionmentioning

confidence: 99%

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Intravascular Coagulation Phenomena Associated with Prevalent Fall in Fibrinogen and Plasminogen during <i>L</i>-Asparaginase Treatment in Leukemic Children

Legnani¹,

Palareti²,

Pession

et al. 1988

Pathophysiol Haemos Thromb

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12 children affected by acute lymphoblastic leukemia had higher baseline levels of Normotest, Antithrombin III activity (AT III:A) and antigen (AT IIl·Ag) than those found in the control group, due to increased liver protein synthesis, as shown by the higher values of 30511bumin. Treatment with L-asparaginase (L-Asp) induced a marked decrease in fibrinogen and plasminogen and only a slight but significant reduction in AT III:A, AT III:Ag, protein C and α₂ antiplasmin levels. Platelet counts progressively increased. Each single L-Asp administration acutely induced (as recorded in the 2-hour postadministration samples) a significant increase in fibrinopeptide A values and reduction in several factors and inhibitors, due to activation of coagulation and consumption phenomena. It is suggested that these acute changes, but not the marked and selective reduction in fibrinogen and plasminogen, were partly compensated during L-Asp treatment by an overall increase in clotting and nonclotting protein synthesis in the liver.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Intravascular Coagulation Phenomena Associated with Prevalent Fall in Fibrinogen and Plasminogen during <i>L</i>-Asparaginase Treatment in Leukemic Children

Legnani¹,

Palareti²,

Pession

et al. 1988

Pathophysiol Haemos Thromb

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“…The infusion of 0.4 µg/kg was able to induce a 10-20% increase in factor XII activity in the mild deficient group, suggesting that the factor XII dependent fibrinolysis can be stimulated by the infusion of DDAVP We have also found a slight increase of factor XII in rabbits only treated with DDAVP. However, other unknown effects of this drug on intrinsic coagulation or contact systems cannot be ruled out (29).…”

Section: Discussionmentioning

confidence: 99%

Effect of DDAVP on Endotoxin-Induced Intravascular Coagulation in Rabbits

1992

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SummaryWe have evaluated the effect of l-Deamino-8D-arginine vasopressin (DDAVP) on an experimental model of intravascular coagulation (DIC) induced in rabbits by injection of 20 µg kg–1 h–1 during 6 h of E. coli lipopolysaccharide. DDAVP significantly ameliorated the platelet drop and fibrinogen decrease (p <0.01) induced by endotoxin in control animals. A significant reduction in factor XII consumption (p <0.01) and a decrease in the generation of endotoxin induced PAI-1 activity in rabbits circulation was also observed (p <0.005). Moreover, fibrin deposition in kidneys of rabbits receiving DDAVP was significantly reduced as compared to control animals. Finally, the mortality rate in the control group was significantly higher than in DDAVP-treated rabbits (p <0.01). The hemostatic changes induced by DDAVP correlated with lower fibrin deposition and reduction in mortality rates.

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“…In order to investigate this aspect, we studied the level of tissue-type plasminogen activator, measured in the plasma euglobulin fraction with added C-1 inactivator (C-1 INA) on fibrin plates (9), in a homozygous Fitzgerald trait patient (immunological and procoagulant activities of HMWKg <I%) after 20 min of venous occlusion. The enzymatic activity of prekallikrein, measured as previously described (10), and its antigenic activity, measured by radial immunodiffusion (11) were 24 and L6 per cent, respectively.…”

mentioning

confidence: 99%