Effect of Dayak Onion Tuber (Eleutherine Americana Merr.) Extract to Prevent Increased Necrosis of Kidney Tubular Epithelial Cells in Mice (Mus Musculus) to Oral Lead Acetate Exposure

Abstract

Objective: This study aims to determine the effect of Dayak onion tuber extract to prevent an increase in necrosis of kidney proximal tubular epithelialcells exposed to lead acetate.Methods: Fresh Dayak onion tuber was extracted with 96% ethanol and then given orally to mice with doses of 65 mg/kg, 130 mg/kg, and 260 mg/kgfor 21 days, accompanied by 14 days of lead acetate on the 8th–21st days. Histological preparations of the mice’s kidney were made by hematoxylinand eosin staining, and then, the necrosis of tubular cells was examined using a ×400 magnification light microscope that observed 5 views randomlymarked by the presence of pyknosis, karyorrhexis, and karyolysis.Results: This study showed the higher the dose of Dayak onion tuber extract and the lower the number of tubular epithelial cell necrosis (p<0.05).Conclusion: Extract of Dayak onion tuber could prevent an increase in necrosis of kidney proximal tubular cells of mice that exposed to lead acetate.

Protective Effect of Toraja Robusta Coffee (Coffee cane-Nora) against Muscle Damage Due to Exercise on Balb/C Mice

“…9 Indonesia has a diverse biodiversity, with the number of plant species reaching 30,000, of which 940 are traditional medicinal plants. 10 One of them is Toraja robusta coffee, which has become an essential part of the economy of Toraja society. 11 It shows how coffee has become an essential commodity in Indonesia and its significant contribution to foreign exchange earnings.…”