Effect of dantrolene sodium on contractility of isolated human uterine muscle

Shin, Young Kwan; Kim, Y.D.; Collea, Joseph V.; Belcher, Michael

doi:10.1016/0959-289x(95)82910-3

Cited by 11 publications

(1 citation statement)

References 26 publications

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“…DS readily crosses the placenta; however, no serious adverse events have been reported in neonates following the maternal administration of DS prior to delivery. Although an equilibrium between maternal and fetal plasma DS concentrations was apparent at 5 min, the fetal levels of DS were approximately 10% of the mother's [71][72][73].…”

Section: Effects Of Ds On Pregnancy and Fetus Pregnancymentioning

confidence: 91%

Current clinical application of dantrolene sodium

Yang

Choi

et al. 2023

Anesth Pain Med

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Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration. However, it is difficult to administer DS intravenously to manage MH. MH is life-threatening, pharmacogenomically related, and induced by depolarizing neuromuscular blocking agents or inhalational anesthetics. All anesthesiologists should know the pharmacology of DS. DS suppresses Ca2+ release from ryanodine receptors (RyRs). RyRs are expressed in various tissues, although their distribution differs among subtypes. The anatomical and physiological functions of RyRs have also been demonstrated as effective therapeutic drugs for cardiac arrhythmias, Alzheimer’s disease, and other RyR-related diseases. Recently, a new formulation was introduced that enhanced the hydrophilicity of the lipophilic DS. The authors summarize the pharmacological properties of DS and comment on its indications, contraindications, adverse effects, and interactions with other drugs by reviewing reference articles.

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Section: Effects Of Ds On Pregnancy and Fetus Pregnancymentioning

confidence: 91%