Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials

Lima, Ana Carolina Delgado; Cecatti, Clara; Fidélix, Melaine; Adorno, Maria Ângela Tallarico; Sakamoto, Isabel Kimiko; César, Thaís Borges; Sivieri, Kátia

doi:10.1089/jmf.2018.0080

Cited by 106 publications

(57 citation statements)

References 38 publications

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“…Dietary supplementation with fruit juices that may have positive effects in modulating lithogenesis of kidney stone formers [146] is also associated with increased gut microbiota biodiversity and representation of taxa with health-promoting activities, such as Bifidobacteria [147][148][149][150]. Consumption of fruit juices is associated with increased fecal and urinary levels of metabolites of microbial origin exhibiting favorable metabolic activities [150,151].…”

Section: Fav Intake Legume Intake and Microbiotamentioning

confidence: 99%

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

et al. 2020

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Recent studies have shown that patients with kidney stone disease, and particularly calcium oxalate nephrolithiasis, exhibit dysbiosis in their fecal and urinary microbiota compared with controls. The alterations of microbiota go far beyond the simple presence and representation of Oxalobacter formigenes, a well-known symbiont exhibiting a marked capacity of degrading dietary oxalate and stimulating oxalate secretion by the gut mucosa. Thus, alterations of the intestinal microbiota may be involved in the pathophysiology of calcium kidney stones. However, the role of nutrition in this gut-kidney axis is still unknown, even if nutritional imbalances, such as poor hydration, high salt, and animal protein intake and reduced fruit and vegetable intake, are well-known risk factors for kidney stones. In this narrative review, we provide an overview of the gut-kidney axis in nephrolithiasis from a nutritional perspective, summarizing the evidence supporting the role of nutrition in the modulation of microbiota composition, and their relevance for the modulation of lithogenic risk.

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Section: Fav Intake Legume Intake and Microbiotamentioning

confidence: 99%

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

et al. 2020

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“…and total anaerobes in fecal samples. In addition, a significant reduction in ammonium concentration and an increase in the acetate to total SCFA ratio were found compared to the baseline [69]. Daily supplementation of two orange juices with different flavanone content for seven days in healthy volunteers resulted in microbiota composition shifts, of which the most notable was an increase in the abundance of Clostridia operational taxonomic units from Mogibacteriaceae, Tissierellaceae, Veillonellaceae, Odoribacteraceae, and Ruminococcaceae families [70].…”

Section: Effects On Microbiota Compositionmentioning

confidence: 99%

The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health

et al. 2019

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Citrus flavanones, with hesperidin and naringin as the most abundant representatives, have various beneficial effects, including anti-oxidative and anti-inflammatory activities. Evidence also indicates that they may impact the intestinal microbiome and are metabolized by the microbiota as well, thereby affecting their bioavailability. In this review, we provide an overview on the current evidence on the intestinal fate of hesperidin and naringin, their interaction with the gut microbiota, and their effects on intestinal barrier function and intestinal inflammation. These topics will be discussed as they may contribute to gastrointestinal health in various diseases. Evidence shows that hesperidin and naringin are metabolized by intestinal bacteria, mainly in the (proximal) colon, resulting in the formation of their aglycones hesperetin and naringenin and various smaller phenolics. Studies have also shown that citrus flavanones and their metabolites are able to influence the microbiota composition and activity and exert beneficial effects on intestinal barrier function and gastrointestinal inflammation. Although the exact underlying mechanisms of action are not completely clear and more research in human subjects is needed, evidence so far suggests that citrus flavanones as well as their metabolites have the potential to contribute to improved gastrointestinal function and health.

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“…Similarly, studies investigating the impacts of single foods, e.g. those rich in antioxidant vitamins or polyphenols like berries, apples, orange, kiwi fruits, herbs or red wine, have reported variable results with regard to the impact on either gut microbiota or serum markers of lipid and glucose metabolism [39][40][41][42][43][44]. An interesting approach was taken in studies in which several dietary components were combined with the intent of improving cardiovascular health.…”

Section: Dietary Interventionsmentioning

confidence: 99%

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

et al. 2020

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Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials

Cited by 106 publications

References 38 publications

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis. A Nutritional Perspective

The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

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