Effect of Cynomorium flavonoids on mouse model of perimenopausal depression

Abstract

The effect of Cynomorium flavonoids on mice model of perimenopausal depression was studied. Ovariectomized female mice (n=70) were randomly divided into 7 groups evenly and treated with different concentrations (5-400 mg/mL, of cynomorium flavonoids, gengnian'an capsule and soy isoflavones soft capsule. The model related groups were applied with different stress for consecutive 18 days. Behavior tests were performed on the 27th, 28th, and 29th days of administration. The concentrations of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in serum as well as the 5-hydroxytryptamine (5-HT) and dopamine (DA) in brain homogenates were determined after the last administration. It was found that cynomorium flavonoids have significant effects on the mice with perimenopausal depression.

The effect of curculigoside on mouse model of perimenopausal depression

“…The major treatments for these diseases are based on herbal medicines for energy, the heart, and the spleen (Cheng et al, 2014). A large number of experiments in the early laboratory shows that tonifying kidney yang traditional Chinese medicine has a good therapeutic effect for perimenopausal depression (Miao et al, 2016a, Miao et al, 2016b). Curculigo is one of the tonics used to treat these diseases, affecting the kidney, liver, and spleen, suggesting its possible effectiveness for perimenopausal depression.…”

Effectiveness of mesenchymal stems cells cultured by hanging drop vs. conventional culturing on the repair of hypoxic-ischemic-damaged mouse brains, measured by stemness gene expression

“…MSCs migration ability is an important characteristic of the MSCs, which is not only the foundation of MSCs' autonomous migration to the damaged tissue after intravenous injection, but also the theoretical basis of MSCs intravenous injection treatment of visceral injuries and systemic diseases, such as myocardial infarction [23]. Recent studies indicate that inflammatory chemokine receptors, especially CCR1 and CCR2, are closely related to MSCs migration ability in/during myocardial infarction [24][25][26][27][28]. The expression reduction of MSCs surface migration related receptor and oversize cause a decline or loss of MSCs migration capability, resulting in more than 70% of MSCs obstructed in the lung after intravenous injection and only a very small amount (<5%) of the cells reached the infarct cardiac tissue [29][30][31][32].…”

Effect of cynomorium flavonoids on morphology of perimenopausal depression mice model

“…The effects of receptor metabolism, endocrine, autonomic nerve and other factors, depend mainly on the physical and psychological aspects of the body and the psychological aspects of the abnormal, the mood swings, and the high degree of depression in patients (Lin et al, 2014). Because estrogen secretion is leading to abnormal perimenopausal the main influence factors and stressful life practice are significant factors of promoting depression (Li et al, 2013), so this experiment takes the removal of both ovaries, then the mice were continued stress which was made in perimenopausal depression model (Miao et al, 2016). Due to castrated mice after a drop in estrogen levels, atrophy of uterus and immunity decreased through the observation and study of Cynomorium songaricum flavone on mouse uterus, thymus gland, hypothalamus and spleen influence to explore the therapeutic effect of C. songaricum flavone of Menopause Depression.…”