Effect of Cynoglossum zeylanicum (Vehl ex Hornem) Thunb. Ex Lehm on Oral Glucose Tolerance in rats

Anitha, M.; Sakthidevi, G.; Muthukumarasamy, S; Mohan, V. R.

doi:10.7324/japs.2012.21113

Cited by 14 publications

(17 citation statements)

References 8 publications

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“…DOI: http://dx.doi.org/10. 22192/ijcrcps.2017.04.04.004 Hyperglycemia is an important factor in the development and progression of the complications of diabetes mellitus (Anitha et al, 2012). Several medicinal plants have been found to be successfully in diabetes treatment and some of them have been tested and their active ingredients isolated (Grover et al, 2002;Shu, 1998).…”

Section: Introductionmentioning

confidence: 99%

Conyza aegyptiaca (L.) Dryand ex. Aiton effect on blood glucose levels in normal albinos rats through oral glucose tolerance test

Akpovi¹,

Aïkpé²,

Kinsou³

et al. 2017

Int. J. Curr. Res. Chem. Pharm. Sci

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Conyza aegyptiaca (L.) Dryand ex. Aiton (C. aegyptiaca) is used in West Africa for diabetes treatment without any scientific study and adequate therapeutic indications. Our previous study shows that C. aegyptiaca extract is nontoxic on larvaes and prevent hepatic glucose liberation in rat. In the present study, we evaluated the acute oral toxicity of C. aegyptiaca aqueous and ethanolic extracts at a unique dose of 300 and 2000 mg/kg body weight (bw). We also determined its effect on blood glucose level by the Oral Glucose Tolerance Test (OGTT) on albinos Wistar rats. Acute oral toxicity showed no mortality and no toxic effect throughout the study. There were no significant changes in glycaemia, creatinine, lipids, AST, ALT and ions Ca 2+ , Cl -, Na+, K + , and Mg 2+ levels when compared to control. OGTT showed that only the aqueous extract at the dose of 500 mg/kg bw normalized blood glucose level 75 min after OGTT induction compared to 60 min for Glybenclamide. Results suggest that C. aegyptiaca aerial part extract is safe and possesses anti-hyperglycemia potential. Further studies are needed to isolate and characterize the plant active component and to test it for diabetes treatment.

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Section: Introductionmentioning

confidence: 99%

Conyza aegyptiaca (L.) Dryand ex. Aiton effect on blood glucose levels in normal albinos rats through oral glucose tolerance test

Akpovi¹,

Aïkpé²,

Kinsou³

et al. 2017

Int. J. Curr. Res. Chem. Pharm. Sci

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show abstract

“…Two case studies of oral glucose tolerance in rats [2,14] are showed to analyze. In the present investigation, 36 normal rats were fasted for 12h and assigned randomly into 6 equal groups (n= 6/group) [14].…”

Section: Results and Practical Data Of Oral Glucose Tolerance Testmentioning

confidence: 99%

“…In the other investigation, a total 20 normal rats were taken and divided into four groups for oral glucose tolerance test (each group 5 rats) with an antihyperglicemic plant, Cynoglossum zeylanicum (Boraginaceae) [2]. The concentrated ethanol extract of this medicinal plant was used for the oral glucose tolerance test.…”

Section: Results and Practical Data Of Oral Glucose Tolerance Testmentioning

confidence: 99%

Methodology of Study of an Antihyperglycemic Traditional Cure with Oral Glucose Tolerance Test to Wistar Rat

François¹

2016

AJBIO

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Our aim was to expose a method of study an antihyperglycemic traditional cure with oral glucose tolerance test to wistar rat. This methodology began by obtaining plants species component the cure, their extraction and identification of assets. The traditional cure is composited of leaves of both Heliotropium indicum (Borraginaceae), Ocimum gratissimum (Lamiaceae) and barks of both Sclerocarya birrea, (Anacardiaceae), Khaya senegalensis (Meliaceae). After, experimental animal is chosen and the blood samples are made. The pharmacological criteria took into account the oral antidiabetic therapeutic as the glibenclamide. Then the glucose overload is absorbed by the animals after administration of the test cure in single or multiple outlets. The anhydrous glucose used to induce experimental diabetes is administered at a dose of 4 g/kg/vo. Finally, we carried out the blood glucose. The methodology of study of an antihyperglycemic traditional cure took account the protection of laboratory animals after experimentation.

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“…Apart from using fasting blood glucose alone, OGTT was seen as a practical attempt to simplify and facilitate the diagnosis of diabetes [20]. An oral glucose tolerance test helps in checking on the ability of an organism to regulate blood glucose 2 hrs after receiving 2 g/Kg b.w.…”

Section: Discussionmentioning

confidence: 99%

Effect of Combined Dietary Supplementation of Telfairia Occidentalis Leaves and Citrulus Colocynthis Seeds on Fasting Glycemia, Glucose Tolerance and Body Weight in Wistar Rats

Bc¹,

Cl²,

Cj³

et al. 2017

J Nutr Disorders Ther

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Though medical assistance can be given to diabetic patients, dietary care is highly explored. This work aimed at studying the effects of dietary supplementation of uncooked Telfairia occidentalis leaves combined with Citrulus colocynthis seeds on blood glucose level in Wistar rats. A phytochemical screening was realized on T.occidentalis ethanolic and hydroethanolic leaves extracts, and their acute toxicity was studied in rats. The effect of their combined dietary supplementation on glycemia and body weight was studied in rats receiving carbohydrate enriched diet during 28 days. Three test groups received 10% Telfairia occidentalis leaves, 10% C.colocynthis and a mixture of 5% T.occidentalis leaves and 5% C. colocynthis respectively. Glibenclamide (0.03 mg/kg b.w) was used as reference drug.Glucose tolerance was tested at the end of supplementation period. The presence of tannins, saponins, anthocyanines and flavonoids was revealed in T. occidentalis extracts and no sign of toxicity was identified in rats. Fasting glycemia decreased significantly in rats supplemented with T. occidentalis as compared to positive control and there was no significant increase in glycemia for rats supplemented with C. colocynthis and with both plants. All animals except the positive control showed a good glucose tolerance at the end of supplementation. T. occidentalis showed hypoglycemic properties and its association with C. colocynthis inhibited hyperglycemia and maintained good glucose tolerance. Hence, combined consumption of T. occidentalis leaves with C. colocynthis seeds might be advised in diabetes management.

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Effect of Cynoglossum zeylanicum (Vehl ex Hornem) Thunb. Ex Lehm on Oral Glucose Tolerance in rats

Cited by 14 publications

References 8 publications

Conyza aegyptiaca (L.) Dryand ex. Aiton effect on blood glucose levels in normal albinos rats through oral glucose tolerance test

Conyza aegyptiaca (L.) Dryand ex. Aiton effect on blood glucose levels in normal albinos rats through oral glucose tolerance test

Methodology of Study of an Antihyperglycemic Traditional Cure with Oral Glucose Tolerance Test to Wistar Rat

Effect of Combined Dietary Supplementation of Telfairia Occidentalis Leaves and Citrulus Colocynthis Seeds on Fasting Glycemia, Glucose Tolerance and Body Weight in Wistar Rats

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