Effect of Cyclosporin a on the Function of T Cells

Gunn, Han; Varey, A M; Cooke, Anne

doi:10.1097/00007890-198110000-00017

Cited by 9 publications

(1 citation statement)

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“…These facts indicate that, unlike the generation of CTL, SSTC generation requires no help of amplifyercell-interleukin-2 producers, which cortical thymus lacks. This possibility is supported by T-suppressor generation in spite of the functional T-ampIifyer inactivation by cyclosporine A in murine (Gunn et al 1981) and human MLC (Hess et al 1983), as well as within culture conditions excluding CTL generation because of poor T-amphfyer function (Hodes & Hathcock 1979, Eisenthal et al 1977, Sondel et al 1977. The rapid T-suppressor generation in vivo in tissue culture is promoted by antigen administration in non-optimal amounts (Kontianen & Feldman 1976), in non-physiological form (Chin et al 1980), by non-physiological means of administration (Shimizu et al 1979) or in non-physiological conditions (within burns, for example) (Miller & Cloudy 1979).…”

Section: Discussion and Concluding Remarksmentioning

confidence: 92%

Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Brondz

Abronina

Zaiceva

et al. 1984

Immunological Reviews

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Section: Discussion and Concluding Remarksmentioning

confidence: 92%

Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Brondz

Abronina

Zaiceva

et al. 1984

Immunological Reviews

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Cyclosporin A inhibits the delayed‐type hypersensitivity reaction: impaired production of early pro‐inflammatory mediator(s)

et al. 1984

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The effect of cyclosporin A (CsA) on the delayed-type hypersensitivity (DTH) elicited in mice by sheep red blood cells was investigated. Evidence is presented that a single injection of CsA adversely affects the inflammatory reaction. Sensitized T lymphocytes initiate the DTH reaction by their recruiting activity on phagocytic cells which infiltrate the cutaneous site of antigen deposition. CsA administration has no adverse effect on the recruitment of phagocytic cells at the site of the inflammatory reaction. The present studies show that CsA acts on specific T cells: (a) in adoptive transfer, T-DTH-mediating cells cannot elicit a response in mice treated with CsA 8 h before; (b) when collected 8 h after a single injection of CsA, T-DTH-mediating lymphocytes are no longer able to adoptively transfer the reaction. This conclusion is strengthened by in vitro studies: (a) the frequency of T-DTH-mediating lymphocytes is 50-fold decreased after a short in vitro incubation with CsA; (b) in vitro production by concanavalin A-activated lymphocytes of chemotactic pro-inflammatory mediator(s) is abolished in presence of CsA.

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Functional evaluation of murine allogeneic T lymphoblasts separated by Vicia villosa lectin positivity

Banga¹,

Hutchings²,

Tatham³

et al. 1983

Cellular Immunology

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Effect of Cyclosporin a on the Function of T Cells

Cited by 9 publications

References 0 publications

Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Specific Suppressor T‐Cells Immune to Antigens of the H‐2 Complex: Receptors, Clonal Structure, Genetic Restriction and Antigenic Markers

Cyclosporin A inhibits the delayed‐type hypersensitivity reaction: impaired production of early pro‐inflammatory mediator(s)

Functional evaluation of murine allogeneic T lymphoblasts separated by Vicia villosa lectin positivity

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