“…These facts indicate that, unlike the generation of CTL, SSTC generation requires no help of amplifyercell-interleukin-2 producers, which cortical thymus lacks. This possibility is supported by T-suppressor generation in spite of the functional T-ampIifyer inactivation by cyclosporine A in murine (Gunn et al 1981) and human MLC (Hess et al 1983), as well as within culture conditions excluding CTL generation because of poor T-amphfyer function (Hodes & Hathcock 1979, Eisenthal et al 1977, Sondel et al 1977. The rapid T-suppressor generation in vivo in tissue culture is promoted by antigen administration in non-optimal amounts (Kontianen & Feldman 1976), in non-physiological form (Chin et al 1980), by non-physiological means of administration (Shimizu et al 1979) or in non-physiological conditions (within burns, for example) (Miller & Cloudy 1979).…”