Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats

Abraham, Premila; Indirani, K.; Sugumar, Emila

doi:10.1016/j.etp.2007.05.003

Cited by 29 publications

(23 citation statements)

References 29 publications

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“…Sucrose and other agents implicated in osmotic nephrosis enter the tubular cells by pinocytosis, then pinocytic vacuoles fuse with lysosomes (22). Lysosomal tubular dysfunction has been described secondary to toxic agents such as cyclophosphamide (23), leading in some cases to accumulation of abnormal amounts of proteins and tubular cell swelling. Several reports have emphasized that preexisting kidney disease (10,21) is a risk factor for acute renal failure after IVIg, and it is conceivable that this vulnerability is related to lysosomal function impairment.…”

Section: Discussionmentioning

confidence: 99%

High-Dosage Intravenous Immunoglobulin–Associated Macrovacuoles Are Associated with Chronic Tubulointerstitial Lesion Worsening in Renal Transplant Recipients

Bollée¹,

Anglicheau²,

Loupy³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Design, setting, participants, & measurements: Twenty-seven kidney transplant recipients who had high immunologic risk and were treated with four courses of IVIg after transplantation were studied retrospectively at a transplant center, and findings were compared with those of 27 control subjects. Protocol kidney biopsies were performed at time of transplantation and at 3 mo and 1 yr after transplantation.Results: No episode of IVIg-related acute renal failure occurred. Nevertheless, screening biopsies revealed the presence of "microvacuoles" and "macrovacuoles." Widespread microvacuolizations were often detected (70%) on preimplantation biopsy and not associated with IVIg. Macrovacuoles, which were absent on preimplantation biopsies, were observed exclusively in IVIg-treated patients. Macrovacuoles among IVIg-treated patients were seen in kidneys from older donors and were associated with chronic tubulointerstitial changes at 3 mo, with similar trends at 1 yr. Macrovacuoles were associated with lower creatinine clearance at last follow-up in IVIg-treated patients.Conclusions: IVIg frequently induce tubular macrovacuoles in kidney transplant recipients. These are more frequently observed in grafts from older donors, suggesting a higher vulnerability to IVIg. These data suggest a deleterious impact of IVIg-induced macrovacuoles on chronic tubulointerstitial changes and long-term renal function.

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Section: Discussionmentioning

confidence: 99%

High-Dosage Intravenous Immunoglobulin–Associated Macrovacuoles Are Associated with Chronic Tubulointerstitial Lesion Worsening in Renal Transplant Recipients

Bollée¹,

Anglicheau²,

Loupy³

et al. 2008

Clinical Journal of the American Society of Nephrology

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“…Hingorani et al [8] also reported that post-SCT incident albuminuria and CKD development were closely associated. The developmental mechanism of albuminuria after SCT has not yet been fully investigated, but complex associations of high-dose antitumor drugs included in-conditioning procedures, severe infections such as sepsis, TBI, calcineurin inhibitor-associated vascular and glomerular endothelial disorders, acute GVHD, and immunological and circulatory abnormalities due to engraftment syndrome are considered [16,17,18,19,20]. Based on these studies, a similar mechanism can be speculated for the cause of the incidence of proteinuria, and the association between incident proteinuria and post-transplant CKD development observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Emergence of Dipstick Proteinuria Predicts Overt Nephropathy in Patients Following Stem Cell Transplantation

Momoki

Yamaguchi²,

Ohashi³

et al. 2016

Nephron

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Background: Stem cell transplantation (SCT) places a heavy burden on the kidneys, often resulting in renal dysfunction or nephrotic syndrome. This study attempted to show that early-onset proteinuria predicts the development of overt nephropathy. Methods: A total of 831 patients who received allogeneic SCT were surveyed. Excluding those with prior kidney disease and those lacking in an observation period ≥1 year after SCT, 251 patients were eligible for the study. Dipstick proteinuria ≥1+ within 1 year after SCT was defined as ‘incident proteinuria', and subsequent persistence of an estimated glomerular filtration rate of <60 ml/min/1.73 m² at 1 year or longer after SCT was defined as ‘incident chronic kidney disease (CKD)'. Between-group differences were analyzed using the chi-square or Mann-Whitney U test. Factors associated with the incidence of CKD were investigated by multivariate Cox proportional regression analysis. Kidney-biopsied tissue was examined in all nephrotic syndrome patients. Results: The mean duration of follow-up was 4 years. Thirty-four (13.5%) and 66 (26.3%) patients developed incident proteinuria and incident CKD, respectively. Nine (3.6%) patients developed nephrotic syndrome mainly due to membranous nephropathy. The incidence of CKD was significantly greater in patients with incident proteinuria than those without (61.8 vs. 20.7%, p < 0.0001), and incident dipstick proteinuria was a significant risk for incident CKD (hazard ratio 4.39, 95% CI 2.44-7.73, p < 0.0001). Conclusion: SCT patients who manifest dipstick proteinuria are predisposed to overt nephropathy. Routine monitoring of the urine dipstick test is strongly recommended, as it facilitates early nephrology care for post-SCT patients.

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“…Lysosomal enzymes activities decreased and protein content increased in the kidneys of CP treated rats. The reduction in the lysosomal enzymes activities, may contribute to renal damage (35). At this study, unfortunately there was not any significant healing in the kidneys of treated groups.…”

Section: Discussionmentioning

confidence: 87%

Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice

Araghi¹,

Golshahi²,

Baghban³

et al. 2017

J Herbmed Pharmacol

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Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats

Cited by 29 publications

References 29 publications

High-Dosage Intravenous Immunoglobulin–Associated Macrovacuoles Are Associated with Chronic Tubulointerstitial Lesion Worsening in Renal Transplant Recipients

High-Dosage Intravenous Immunoglobulin–Associated Macrovacuoles Are Associated with Chronic Tubulointerstitial Lesion Worsening in Renal Transplant Recipients

Emergence of Dipstick Proteinuria Predicts Overt Nephropathy in Patients Following Stem Cell Transplantation

Ameliorative action of farnesol on cyclophosphamide induced toxicity in mice

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