Effect of cyclodextrins on the stability of adriamycin, adriamycinol, adriamycinone and daunomycin

Synthesis and Inclusion Study of a Novel γ-Cyclodextrin Derivative as a Potential Thermo-Sensitive Carrier for Doxorubicin

“…7 and 8, the encapsulation efficiencies are all in the same order of magnitude. The results thus indicate a similar chemical stability of the complex 8,32) and comparable encapsulation mode in a wide range of acidic environments and at a wide range of 3b : DOX ratios.…”

“…Calculation of Binding Constant K of 3b to DOX: It has been well reported in the literature that, addition of native γ-CD added to DOX at a ratio of up to 5000 : 1 could significantly stabilize DOX in aqueous solution via complex formation. 32) Other reports, 33) in which DOX encapsulation within CDs could significantly lower the fluorescence and absorbance signals of the guest molecule, demonstrated that CDs can be considered as a fluorophore quencher for DOX. Therefore, the binding constant can be calculated according to modified Stern-Volmer 24) Eq.…”

Separation of doxorubicin and doxorubicinol by cyclodextrin‐modified micellar electrokinetic capillary chromatography

“…The hydrophilic exterior of the cone-shaped CD prevents interaction with hydrophobic analytes, whereas the hydrophobic core allows for varying degrees of complexation. Cavity diameter largely dictates the degree of complexation for a given analyte, with a larger cavity diameter more readily facilitating the separation of molecules with three to four aromatic rings like DOX; a-and b-CD tend to have less complexation for such molecules than comparable g-CD [27,28]. The impact of CD on the separation of DOX and DOXol was investigated by incorporating g-CD into the BS50 buffer system at a final concentration of 20 mM (CD-BS).…”