Studies performed to quantify the pullout strength of suture anchors have not adequately defined the basic device parameters that control monotonic pullout. The bearing area of a suture anchor can be used to understand and predict anchor pullout strength in a softbone model. First, conical-shaped test samples were varied in size and shape and tested for pullout in 5, 8, and 10 pcf sawbone models. Next, bearing area and pullout strength relationships developed from the test samples were validated against nine commercially available suture anchors, including the Mitek QuickAnchor and SpiraLok, Opus Magnum 2 , ArthroCare ParaSorb, and Arthrex BioCorkscrew. The samples showed a direct correlation between bearing area and pullout strength. Increased insertion depth was a secondary condition that also increased pullout strength. The pullout strength for the suture anchors followed the predicted trends of conical devices based on their individual bearing areas. For the 5 and 8 pcf models, only two and three devices, respectively, fell outside the predicted pullout strength range by more than a standard deviation. The use of a synthetic sawbone model was validated against the pullout strength of an Arthrex Corkscrew in five fresh-frozen cadaver humeral heads. The bearing area of a suture anchor can be used to predict the pullout strength independent of design in a soft-bone model. This work helps provide a foundation to understand the principles that affect the pullout strength of suture anchors. Keywords: suture anchors; pullout strength; soft bone; osteoporosis; bearing area Suture anchors are devices used to reattach a torn tendon to bone and are commonly used at active muscles sites. 1 These devices must possess good pullout strength so that rehabilitation can begin shortly after surgery. The pullout strengths of different types of anchors have been compared in a variety of bone models. [2][3][4][5][6][7][8] These studies have had significant clinical impact, but have not laid a foundation to understand basic design parameters controlling monotonic pullout. In some instances, studies were performed in healthy or hardbone models in which pullout is not the dominant mode of failure compared to suture breakage, device breakage, or tendon tearing. 9 Even when device pullout is the dominant failure mode, no fundamental understanding has emerged as to why some anchors perform better than others.In recent studies by Barber et al., 4,10 monotonic pull tests were performed on a range of suture anchors in a porcine model. Smaller sized suture anchors like the BioRaptor 2.9 and AxyaLoop/Parafix 3 mm devices mostly failed due to anchor pullout, while larger 5 to 6.5 mm devices like the SpiraLok, BioCorkscrews, and the AxyaLoop/ParaFix failed due to eyelet or suture breakage. Eyelet breakage was associated with polymer-based anchors; suture breakage was associated with titanium anchors. The study did not comprehensively assess pullout strength, as three modes of failure occurred due to the high bone density of the porc...