Effect of cyanobacteria extract on some associated enzymes in mouse liver in vivo

Piperine Enhances the Antioxidant and Anti-Inflammatory Activities of Thymoquinone against Microcystin-LR-Induced Hepatotoxicity and Neurotoxicity in Mice

“…In the same line, our study revealed severe hepatotoxicity after MC treatment indicated by marked elevations of serum AST, ALT, and ALP levels. These findings support the data obtained by previous reports [1, 36, 37] which studied the change in liver function during MC insult. Previous studies have attributed the MC-induced hepatotoxicity to the high affinity of MC to form strong covalent bonds with hepatic serine/threonine-specific protein phosphatases which potently inhibit their activities [14].…”

“…All of these events played a central role in GSH exhaustion and subsequent reduction in GSH-Px, SOD, and CAT activities. Taken altogether, our data confirm the involvement of oxidative damage in MC-induced toxicity [1, 2, 6, 14, 37, 39, 41].…”

“…Moreover, a growing body of evidence suggests the involvement of oxidative stress in MC-induced hepatotoxicity [1, 6, 14, 37, 39]. Besides the hepatotoxicity, MC has the ability to cross the blood-brain barrier [40] and cause neurotoxicity via possible mechanisms of phosphatase inhibition and oxidative damage [2, 5, 41].…”

Freshwater toxic cyanobacteria induced DNA damage in apple (Malus pumila), rape (Brassica napus) and rice (Oryza sativa)

“…Reversed-phase HPLC analysis showed that the CE had at least three microcystin variants: microcystin-RR, -LR and -YR, in the proportion of 54.9%, 31.0% and 2.7%, respectively. By ELISA the total microcystins level of the toxic bloom sample was 0.4 g of microcystin-LR equivalents per mg dry weight of bloom [21]. By using the crude aqueous extract of the toxic bloom, we found that MCs inhibited the growth Table 1 RAPD primers used in this study.…”