Effect of Cuscuta chinensis water extract on 7,12-dimethylbenz[a]anthracene-induced skin papillomas and carcinomas in mice

Nisa, Mehmoodun; Akbar, Shahid; Tariq, Mohammad; Hussain, Zulfia

doi:10.1016/0378-8741(86)90040-1

Cited by 44 publications

(25 citation statements)

References 13 publications

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“…Tu-Si-Zi (TSZ), the dried seeds of Cuscuta chinensis Lam (Family Convolvulaceae), is an important Chinese traditional medicine widely used to improve sexual function, prevent and treat cardiovascular diseases, treat osteoporosis, and prevent senescence (Zheng et al, 1998). Moreover, it possesses antitumoral, hepaprotective and neuropotective effects (Nisa et al, 1986;Liu et al, 2003;Umehara et al, 2004;Yen et al, 2007). The active constituents of TSZ include flavonoids, lignans, quinic acids and polysaccharides (Du et al, 1998;Wang et al, 2000;Ye et al, 2002bYe et al, , 2005He et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Antiosteoporotic compounds from seeds of Cuscuta chinensis

Yang

Chen

Wang

et al. 2011

Journal of Ethnopharmacology

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“…[2][3][4][5][6][7][8] Most of the active compounds in these extracts still remain unidentified and their presence is detected by biological tests only. 2,3,9,10) The structure and the mechanism of action of others have been elucidated 11,12) and some of them are currently used as drugs in chemotherapy (rubomycine, vinblastine, vincrastine, colchamine, VM-26 etc.). Most of the identified compounds are products of plant secondary metabolism and belong to the classes of alkaloids, 13) polyphenols, 14) triterpenes 15) or are steroid glycosides.…”

mentioning

confidence: 99%

In Vitro Screening for Antitumour Activity of Clinopodium vulgare L. (Lamiaceae) Extracts.

Dzhambazov

Daskalova

Monteva

et al. 2002

Biological & Pharmaceutical Bulletin

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Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 m mg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50% (IC 50 values) were calculated to be 20, 10 and 17.8 m mg/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible.

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“…Flavonoids extracted from the seeds of C. chinensis stimulated the reproductive system and reproductive endocrine function in male rats (Qin et al 2003). Water extract of C. chinensis reduced the incidence of skin carcinoma in mice, and had anti-inflammatory activity (Nisa et al 1985(Nisa et al , 1986. The anti-inflammatory effect was confirmed in C. campestris (Agha et al 1996) and C. tinctoria Mart.…”

Section: Cuscuta Umbrosamentioning

confidence: 77%