Effect of curcumin on glucose and lipid metabolism, FFAs and TNF-α in serum of type 2 diabetes mellitus rat models

Su, Liqing; Wang, Yong-di; Chi, Heng

doi:10.1016/j.sjbs.2017.11.011

Cited by 56 publications

(36 citation statements)

References 15 publications

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“…According to the 2016 Global Report on Diabetes of the World Health Organization (WHO), 422 million people (or 8.5% of the population) were suffering from DM globally. DM and its complications affect the quality of life of human beings, and have become a significant global public health problem [3]. Because of the continuous increase in the numbers of patients and aggravation in prevalence, DM is one of the major chronic noninfectious diseases worldwide, and has imposed a heavy burden on human beings [3].…”

Section: Introductionmentioning

confidence: 99%

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

et al. 2020

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Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study investigated the effect of curcumin in inhibiting high-fat diet and streptozotocin (STZ)-induced hyperglycemia and hyperlipidemia in rats. Twenty-six male Sprague-Dawley (SD) rats (170–190 g) were randomly divided into a standard food pellet diet group (Control group), a high-fat diet and streptozotocin group (HF + STZ group), and a high-fat diet combined with curcumin and STZ group (HF + Cur + STZ group). Compared with the HF + STZ group, the HF + Cur + STZ group exhibited significantly reduced fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (AST), and aspartate transaminase (ALT) levels, as well as liver coefficients. In the livers of these rats, the expression of malondialdehyde (MDA) and Bax was downregulated, whereas that of superoxide dismutase (SOD) and Bcl-2 was upregulated. Moreover, the liver histology of these rats was improved and resembled that of the control rats. These results suggest that curcumin prevents high-fat diet and STZ-induced hyperglycemia and hyperlipidemia, mainly via anti-oxidant and anti-apoptotic mechanisms in the liver.

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Section: Introductionmentioning

confidence: 99%

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

et al. 2020

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“…However, treatment with C. longa, V. album and pre-eminently co-treatment with C. longa + V. album showed a potent ability in increasing the antioxidant levels and scavenging free radicals which perhaps aggravated diabetic conditions. Plant source bioflavonoids have been reported to be an excellent candidate for free radical scavenging [58] therefore, curcumin from C. longa and lectin from V. album are excellent antioxidant and has also been demonstrated to be potent in the management of diabetes [59,60].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and Antioxidant Capacity of <i>Curcuma Longa</i> and <i>Viscum Album</i> in Alloxan Induced Diabetic Male Wistar Rats

Onyenibe¹,

Nathaniel²,

Udogadi³

et al. 2019

IJDE

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Plant based therapies may be a potent means of managing and preventing diabetes and currently, combination therapies are employed for the treatment of critical diseases. In view of this, the objectives of the present study was to investigate the hypoglycemic and antioxidant capacity C. longa, V. album and co-treatment with C. longa + V. album on diabetes and its related complication. Qualitative phytochemical analysis of C. longa and V. album were examined using standard procedures and the result revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, saponins, tannins, terpenoids and steroids respectively. Thirty six (36) male albino rats with the mean weight between 120-135g were divided into six (6) groups (n=6), group one (1) served as the normal control and there experimental groups were diabetic, induced with 150 mg/kg intraperitoneal alloxan injection. Body weight, blood sugar level, glycated hemoglobin, glucose-6phosphate dehydrogenase, α-amylase, lipid profile, liver function and antioxidant markers were determined using standard procedures and the results revealed that, co-treatment with C. longa + V. album demonstrated an excellent weight reduction ability, hypoglycemic capacity, modulation of G6PDH, HBA 1 C and lipid profile, inhibition of α-amylase and enhancement of liver function and antioxidant levels. Therefore, co-treatment with C. longa + V. ablum can be a good therapeutic choice for the management of diabetes and its related conditions.

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“…We tested the effect of curcumin analogs in a STZinduced model of type 1 diabetes. Previous studies have shown that curcumin reduces glycemia in type 2 models (36), and improves insulin resistance (37). Therefore, in type 2 diabetes, curcumin may provide protective effects by reducing the stimulus (hyperglycemia and dyslipidemia) (38).…”

Section: Toxicity Studies and The Effects Of Curcumin Analogs On Bloomentioning

confidence: 99%

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes

et al. 2019

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Chronic inflammation and oxidative stress lead to a multitude of adverse cellular responses in target organs of chronic diabetic complications. Curcumin, a highly investigated phytochemical, has been shown to exhibit both anti-inflammatory and antioxidant activities. However, the clinical application of curcumin has been greatly limited due to a poor pharmacokinetic profile. To overcome these limitations, we have generated analogs of curcumin to enhance bioavailability and offer a preferable pharmacokinetic profile. Here, we explored the effects of two mono-carbonyl curcumin analogs, L2H21 and L50H46, in alleviating indices of inflammation and oxidative stress in cell culture and mouse model of diabetic complications. Our results show that L2H21 and L50H46 normalize inflammatory mediators (IL-6 and TNF-α), extracellular matrix proteins (FN and COL4α1), vasoactive factors (VEGF and ET-1) and a key transcriptional coactivator (p300) in cultured human retinal microvascular endothelial cells (HRECs) and dermal-derived microvascular endothelial cells (HMVECs) challenged with high levels of glucose. These curcumin analogs also reduced glucose-induced oxidative DNA damage as evidenced by 8-OHdG labeling. We further show that treatment of streptozotocin-induced diabetic mice with curcumin analogs prevents cardiac and renal dysfunction. The preservation of target tissue function was associated with normalization of pro-inflammatory cytokines and matrix proteins. Collectively, our results show that L2H21 and L50H46 offer the anti-inflammatory and antioxidant activities as has been reported for curcumin, and may provide a clinically applicable therapeutic option for the treatment of diabetic complications.

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Effect of curcumin on glucose and lipid metabolism, FFAs and TNF-α in serum of type 2 diabetes mellitus rat models

Cited by 56 publications

References 15 publications

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Hypoglycemic and Antioxidant Capacity of <i>Curcuma Longa</i> and <i>Viscum Album</i> in Alloxan Induced Diabetic Male Wistar Rats

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes

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Effect of curcumin on glucose and lipid metabolism, FFAs and TNF-α in serum of type 2 diabetes mellitus rat models

Cited by 56 publications

References 15 publications

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Hypoglycemic and Antioxidant Capacity of &lt;i&gt;Curcuma Longa&lt;/i&gt; and &lt;i&gt;Viscum Album&lt;/i&gt; in Alloxan Induced Diabetic Male Wistar Rats

Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes

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Hypoglycemic and Antioxidant Capacity of <i>Curcuma Longa</i> and <i>Viscum Album</i> in Alloxan Induced Diabetic Male Wistar Rats