Effect of Curcumin on Fatty Acid Synthase Expression and Enzyme Activity in Breast Cancer Cell Line SKBR3

Younesian, Ommolbanin; Kazerouni, Faranak; Dehghan-Nayeri, Nasrin; Omrani, Davood; Rahimipour, Ali; Shanaki, Mehrnoosh; Kalkhoran, Maryam Rezapour; Cheshmi, Fatemeh

doi:10.5812/ijcm.8173

Cited by 13 publications

(13 citation statements)

References 28 publications

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“…This inhibition was associated with the regulation of AKT phosphorylation, Bax, and Bcl-2 protein expressions [ 204 ]. FAS inhibition–mediated apoptosis was also reported in curcumin-treated SKBR-3 cells [ 205 ]. Moreover, Tafazzin (TAZ) and Yes-associated protein (YAP) are the key effectors of the Hippo signaling pathway.…”

Section: Curcumin: Impacts On Multiple Cellular Signaling Pathways In Hormone-independent Breast Cancermentioning

confidence: 83%

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Farghadani

Naidu

2021

Cancers

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Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide. Despite the overall successes in breast cancer therapy, hormone-independent HER2 negative breast cancer, also known as triple negative breast cancer (TNBC), lacking estrogens and progesterone receptors and with an excessive expression of human epidermal growth factor receptor 2 (HER2), along with the hormone-independent HER2 positive subtype, still remain major challenges in breast cancer treatment. Due to their poor prognoses, aggressive phenotype, and highly metastasis features, new alternative therapies have become an urgent clinical need. One of the most noteworthy phytochemicals, curcumin, has attracted enormous attention as a promising drug candidate in breast cancer prevention and treatment due to its multi-targeting effect. Curcumin interrupts major stages of tumorigenesis including cell proliferation, survival, angiogenesis, and metastasis in hormone-independent breast cancer through the modulation of multiple signaling pathways. The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-ĸB pathway, p53 pathway, and Wnt/β-catenin, as well as apoptotic and cell cycle pathways. Besides, its therapeutic implications in clinical trials are here presented.

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Section: Curcumin: Impacts On Multiple Cellular Signaling Pathways In Hormone-independent Breast Cancermentioning

confidence: 83%

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Farghadani

Naidu

2021

Cancers

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“…Curcumin also down-regulated the transcription levels of Cd36, Srebf1 and Fasn, and up-regulated the transcription levels of Ppara and HSL in IUGR rats. Previous studies indicated that curcumin could suppress the gene expression of Fasn (42) and activate protein expression of PPARα (43) . According to the results of the present study, we could confirm that curcumin could promote lipolysis and fatty acid oxidation in the liver of IUGR rats.…”

Section: Discussionmentioning

confidence: 99%

Curcumin attenuates insulin resistance and hepatic lipid accumulation in a rat model of intra-uterine growth restriction through insulin signalling pathway and sterol regulatory element binding proteins

Ahmad

et al. 2019

Br J Nutr

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The objective of the present study was to investigate the effect of curcumin on insulin resistance (IR) and hepatic lipid accumulation in intra-uterine growth restriction (IUGR). Rats with a normal birth weight (NBW) or IUGR were fed basic diets (NBW and IUGR groups) or basic diets supplemented with curcumin (NBW-C and IUGR-C groups) from 6 to 12 weeks. Rats in the IUGR group showed higher levels of glucose and homeostasis model assessment for insulin resistance index (HOMA-IR) (P < 0·05) than in the NBW group. The livers of IUGR rats exhibited higher (P < 0·05) concentration of TAG and lower (P < 0·05) activities of lipolysis enzymes compared with the normal rats. In response to dietary curcumin supplementation, concentrations of serum insulin, glucose and HOMA-IR, pyruvate, TAG, total cholesterol and NEFA in the liver were decreased (P < 0·05). The concentrations of glycogen and activities of lipolysis enzymes in the liver were increased (P < 0·05) in the IUGR-C group compared with the IUGR group. These results were associated with lower (P < 0·05) phosphorylated insulin receptor substrate 1, protein kinase B or Akt, glycogen synthase kinase 3β and expressions of sterol regulatory element binding protein 1 and fatty acid synthase (FASN); decreased expressions for Cd36, sterol regulatory element binding protein 1c (Srebf1) and Fasn; increased (P < 0·05) expression of PPARα; and expressions for Ppara and hormone-sensitive lipase in the liver of IUGR-C rats than the IUGR rats. Maternal malnutrition caused IR and lipid accumulation in the liver. Curcumin supplementation prevented IR by regulating insulin signalling pathways and attenuated hepatic lipid accumulation.

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“…For instance, resveratrol induces apoptosis in the cancer stem-like cells through suppression of FA synthesis by modulating the expression of FASN . Amentoflavone and catechin gallate derivatives (including EGCG, epicatechin gallate, and catechin gallate) have also anti-FASN activity both in vitro and in vivo . − Osthole and amentoflavone downregulate FASN and human epidermal growth factor receptor 2 (HER2) protein expression in HER2 overexpressing cancer cell lines. , Capsaicin, curcumin, tannic acid, and primisterin inhibit FASN expression and its activity in different cancers. − EGCG inhibits FASN activity and induces apoptosis in breast cancer without inducing weight loss in animal models . Likewise, several flavonoids such as luteolin, quercetin, kaempferol, taxifolin, and baicalein were identified as inhibitors of FASN activity, with the first three compounds being most potent .…”

Section: Phytocompounds Inhibiting Metabolism Of Cancermentioning

confidence: 99%

Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance

Khan

Siddiqui

Husain

et al. 2021

J. Agric. Food Chem.

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The metabolism of cancer is remarkably different from that of normal cells and confers a variety of benefits, including the promotion of other cancer hallmarks. As the rewired metabolism is a near-universal property of cancer cells, efforts are underway to exploit metabolic vulnerabilities for therapeutic benefits. In the continued search for safer and effective ways of cancer treatment, structurally diverse plant-based compounds have gained substantial attention. Here, we present an extensive assessment of the role of phytocompounds in modulating cancer metabolism and attempt to make a case for the use of plant-based compounds in targeting metabolic vulnerabilities of cancer. We discuss the pharmacological interactions of phytocompounds with major metabolic pathways and evaluate the role of phytocompounds in the regulation of growth signaling and transcriptional programs involved in the metabolic transformation of cancer. Lastly, we examine the potential of these compounds in the clinical management of cancer along with limitations and challenges.

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Effect of Curcumin on Fatty Acid Synthase Expression and Enzyme Activity in Breast Cancer Cell Line SKBR3

Cited by 13 publications

References 28 publications

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer

Curcumin attenuates insulin resistance and hepatic lipid accumulation in a rat model of intra-uterine growth restriction through insulin signalling pathway and sterol regulatory element binding proteins

Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance

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