Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats

Abstract

This study deals with the effects of freeze dried rhizome powder of Curcuma longa (C. longa) dissolved in milk on normal as well as diabetic models. Diabetes of type II and type I was within 3 days of a single administration of doses of 45 and 65 mg kg(-1) of streptozotocin respectively. Various parameters such as blood glucose levels, triglycerides, total cholesterol, high density lipoprotein, very low density lipoprotein, low density lipoprotein, serum glutamic oxaloacetic transaminase, serum glutamic pyruvate transaminase, alkaline phosphatase, creatinine, hemoglobin, urine protein and urine sugar in addition to body weight were taken in to consideration and were analyzed after administration of variable doses of rhizome powder. The dose of 200 mg kg(-1) was identified as the most effective dose as it increased HDL, Hb and bw (P<0.05) with significant decrease in the levels of blood glucose, lipid profile and hepatoprotective enzymes (P<0.001).

Antioxidant and toxicological evaluation ofCassia sopherain streptozotocin-induced diabetic Wistar rats

“…The increased activity of this enzyme may be by either STZ- or hyperglycemia-induced tissue damage. Rai et al .,[23] reported an increase in ALP activity after induction of diabetes with STZ. In the present study, treatment with AECS and glibenclamide for 28 days showed a marked decrease in serum ALP activity.…”

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

“…EMC-1000 revealed significant reduction in serum creatinine and improvement in serum albumin and total protein level when compared with the diabetic animals sensitive lipases, which increase the lipolysis and releases more free fatty acids in the circulation. Increased fatty acid concentration also augments the b-oxidation of fatty acids, producing more acetyl-CoA, and cholesterol, which further enhances the development of atherosclerosis in DM [10,38,39]. Diabetic animals showed significant increase in the level of triglycerides, serum cholesterol, LDL cholesterol and decrease in HDL-cholesterol levels, while, administration of EMC demonstrated significant and dose dependant reduction in levels of serum triglyceride, serum cholesterol, LDL-cholesterol, and improvement in HDLcholesterol levels.…”

Antioxidant activities of different parts of Gnetum gnemon L.

“…It is known that plant produce phytochemicals to protect itself, but recently, natural phytochemicals have gained a lot of attention as these phytochemicals have shown tremendous advantages to human health (Mehta et al 2010;Rai et al 2010a;Rai et al 2010b;Sharma et al 2009). Some of the well-known phytochemicals are flavonoids, phenolic compounds, lycopenes and carotenoids.…”