Effect of Curculigo orchioides rhizomes on sexual behaviour of male rats

Chauhan, Nagendra Singh; Rao, Ch. V.; Dixit, Vinod Kumar

doi:10.1016/j.fitote.2007.06.005

Cited by 73 publications

(51 citation statements)

References 9 publications

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“…loss associated with hyperglycemia. 6 No such effect was observed in case of glibenclamide or sildenafil treatment. The difference in secondary sexual organ weights could mainly be contributed to the gain in b.w., which may be attributed to the presence of anabolic steroids and steroidal saponins present in the CO extract.…”

Section: Discussionmentioning

confidence: 98%

“…It may also be a possibility that administration of CO is effective in ensuring the better availability of hormone to gonads. 6 Previous reports on the ability of CO in reducing glucose levels, along with its anabolic and antioxidant potential [30][31][32] could provide some insight into the possible mechanism behind the restoration of normal copulatory rate in diabetic animals. In concordance it can be implicated that the multifaceted effect of CO extract acting at different levels of endocrine system accompanied by prevention and amelioration of oxidative damage may be hypothesized as a major contributor to the observed effects.…”

Section: Discussionmentioning

confidence: 99%

“…3 Second, it would be fruitful to evaluate the effects of CO on in vivo glucose metabolism in detail and its correlation with the steroid biogenesis. 5,6 Further studies on genetically modified rats mimicking human diabetic conditions may be worth a trial to get a better insight into the possible mechanism by which CO ameliorates and improve sexual and reproductive parameters in hyperglycemic conditions. Effects on libido and sexual motivation may also be well determined only if the studies are carried out on a larger scale at clinical level.…”

Section: Discussionmentioning

confidence: 99%

“…(family Amaryllidaceae) is a well-known herb in traditional Indian system of medicine and has been designated as a Vajikaran Rasayan. 6,7 It is claimed to be useful in treatment of piles, asthma, jaundice, diarrhea, colic, gonorrhea and sexual dysfunction. 8 It is also a constituent of 'Chywanprash' an age-old Ayurvedic formulation reported in ancient texts for invigorating and rejuvenating the physiological functions.…”

Section: Introductionmentioning

confidence: 99%

“…CO has been used in several metabolism enhancing and aphrodisiac formulation in the Indian system of medicine. Rhizomes possess immunostimulant 7 aphrodisiac, 5,6 antidiabetic 9 and hepatoprotective activity. 10 Diabetes and sustained hyperglycemia results in reduced libido.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats

et al. 2011

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Sustained hyperglycemia is considered as a major cause of sexual and erectile dysfunction in human population. Curculigo orchioides (CO) is considered as a sexual tonic in Ayurvedic system of medicine with potent antioxidant and adaptogenic properties. The aqueous extract of the herb was evaluated for its effectiveness against streptozotocin-induced hyperglycemic stress and subsequent sexual dysfunction due to hyperglycemia in male rats. Six groups with eight male rats in each group were used for this study and the study was carried out for 28 days. The body and organ weights of the animals were recorded. Behavioral analysis of rats was undertaken to observe the effect on mount, ejaculation and intromission (latencies and frequencies) and hesitation time. Blood glucose and serum testosterone levels were determined 28 days past treatment with CO at 100 and 200 mg kg À1 doses. Glibenclamide and sildenafil citrate were used as positive controls. This deleterious effect of sustained hyperglycemia and associated stress was prominently ameliorated in animals treated with aqueous extract of CO. CO treatment was helpful in ameliorating the damage caused by sustained hyperglycemia evidenced in the principle parameters viz. male sexual behavior, sperm count, penile erection index and seminal fructose content Antioxidant and anabolic activities of the extract under investigation could be a major attribute in preserving the sexual functions in hyperglycemic male rats. The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency.

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Section: Discussionmentioning

confidence: 98%