Effect of culture pH on the antioxidant properties of Antrodia camphorata in submerged culture

Molecular cloning and expression analysis of mevalonate pyrophosphate decarboxylase inAntrodia cinnamomea

“…Previous studies demonstrated that the triterpenoid biosynthesis of A. cinnamomea is significantly affected by several environmental factors, such as light, elicitor, substrate, pH value, and developmental stages [29][30][31]. The gene expression levels of Ac-mvd were the highest in the mycelia of A. cinnamomea on the 7th day of the submerged culture.…”

“…A. cinnamomea is expensive because of several characteristics, such as high medicinal value, scarcity in nature, and difficulty in artificial cultivation. The fruiting body and mycelium extracts of A. cinnamomea have been used as a medicine to improve the activity of organisms in studies involving cell lines and animal models in vivo and in vitro; A. cinnamomea extracts provide anti-oxidative [2], anticancer, anti-hepatitic [3], and anti-inflammatory properties [4]. Previous studies showed that the main active ingredients of A. cinnamomea are antroquinonol [5], succinic acid, maleic acid [6], benzenoids [7], triterpenoids [8], and polysaccharides [9].…”

Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases

“…It is well known that free radicals derived from oxygen and other chemicals are important factors related to injury of the liver (Poli, 1993). Accumulating data have shown that Niuchangchih is a potent direct free radical scavenger (Huang et al, 1999;Song and Yen, 2002;Hsiao et al, 2003;Mau et al, 2004;Shu and Lung, 2008). It is therefore possible that prevention against liver injury by Niuchangchih is partially due to its antioxidant activity.…”

Synergism Effect Between Inoculum Size and Aggregate Size on Flavonoid Production in Centella Asiatica (L.) Urban (Pegaga) Cell Suspension Cultures

“…However, the growth was inhibited at the initial pH lower than 5.0 or higher than 6.0 [27]. In addition, Shu and Lung [31] also stated that a higher culture pH might facilitate the transport of methanol-soluble metabolites from mycelia of Antrodia camphorate into the medium. The formation of reddish culture during high pH regime might be due to the presence of high content of anthocyanin, which was the end product in the flavonoid pathway.…”