Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng

Xu, Xinglian; Qu, Wenjia; Jing, Zhe; Han, Ting; Liu, Mengnan; Bai, Yuying; Wang, Min; Lin, Rui‐Chao; Hua, Qian; Li, Xiang-Ri

doi:10.1016/j.biopha.2021.111280

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…Longer years of cultivation and a natural environment lead to better pharmacological effects of ginseng. 116,117 The components of ginseng vary for different regions and cultivation ages, and this may cause different levels of “Shanghuo”. For example, the content of ginsenosides Rg3, Rf, Rk1 and Rg5 remarkably increased with longer years of cultivation.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, a comparable study is required to further explore the effects of ginseng cultivation regions and number of years on "Shanghuo" so that appropriate ginseng products can be chosen based on the demands and physical conditions while limiting the occurrence of "Shanghuo". 117,118 Moreover, there are many limitations in existing clinical trials studying ginseng and "Shanghuo". Some have a small sample size, while others lack the diversity of ginseng samples (fresh ginseng, dried ginseng, red ginseng).…”

Section: Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Ginseng and “Shanghuo” (fireness): a comprehensive review from the viewpoints of TCM theory and modern science

Tan

Zhang

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Ginseng and “Shanghuo” (fireness): a comprehensive review from the viewpoints of TCM theory and modern science

Tan

Zhang

et al. 2023

Food Funct.

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“…Many results demonstrate that TCM, which regulates autophagy, is a potential therapeutic candidate for neurodegenerative disease treatment (Wang Z. Y. et al, 2021 ), or attenuating Aβ and tau pathology in experimental AD models (Iyaswamy et al, 2020b ). It is not surprising that there have been many reports on preventing and treating AD with TCM (Kim et al, 2017 ; Xu et al, 2021 ). For example, Yuan-Hu Zhi Tong Prescription mitigates tau pathology.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease

Wang

Cheng

et al. 2022

Front. Aging Neurosci.

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BackgroundAlzheimer's disease (AD) is becoming a more prevalent public health issue in today's culture. The experimental study of Coptidis Rhizoma (CR) and its chemical components in AD treatment has been widely reported, but the principle of multi-level and multi-mechanism treatment of AD urgently needs to be clarified.ObjectiveThis study focuses on network pharmacology to clarify the mechanism of CR's multi-target impact on Alzheimer's disease.MethodsThe Phytochemical-compounds of CR have been accessed from the Traditional Chinese Medicine Database and Analysis Platform (TCMSP) and Symmap database or HPLC determination. The values of Oral Bioavailability (OB) ≥ 30% and Drug Like (DL) ≥ 0.18 or blood ingredient were used to screen the active components of CR; the interactive network of targets and compounds were constructed by STRING and Cytoscape platform, and the network was analyzed by Molecular Complex Detection (MCODE); Gene Ontology (GO) function, Kyoto Encyclopedia of Genes and Genomes Pathway (KEGG) and metabolic pathway enrichment of targets were carried out with Metascape, the Database for Annotation, Visualization and Integrated Discovery (DAVID) and MetaboAnalyst platform; Based on CytoHubba, the potential efficient targets were screened by Maximal Clique Centrality (MCC) and Degree, the correlation between potential efficient targets and amyloid β-protein (Aβ), Tau pathology was analyzed by Alzdata database, and the genes related to aging were analyzed by Aging Altas database, and finally, the core targets were obtained; the binding ability between ingredients and core targets evaluated by molecular docking, and the clinical significance of core targets was assessed with Gene Expression Omnibus (GEO) database.Results19 active components correspond to 267 therapeutic targets for AD, of which 69 is potentially effective; in module analysis, RELA, TRAF2, STAT3, and so on are the critical targets of each module; among the six core targets, RELA, MAPK8, STAT3, and TGFB1 have clinical therapeutic significance; GO function, including 3050 biological processes (BP), 257 molecular functions (MF), 184 cellular components (CC), whose functions are mainly related to antioxidation, regulation of apoptosis and cell composition; the HIF-1 signaling pathway, glutathione metabolism is the most significant result of 134 KEGG signal pathways and four metabolic pathways, respectively; most of the active components have an excellent affinity in docking with critical targets.ConclusionThe pharmacological target prediction of CR based on molecular network pharmacology paves the way for a multi-level networking strategy. The study of CR in AD treatment shows a bright prospect for curing neurodegenerative diseases.

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“…At present, the ginseng root and its extract are the most widely used herbal medicine. Modern pharmacological studies have proved that ginsenosides are the main active ingredient of ginseng and have a wide range of pharmacological effects, such as anti-inflammatory ( Xu et al, 2021 ; Yi, 2021 ), anticancer ( Zhang et al, 2021a ), and anti-viral ( Kang et al, 2021 ), regulate immunity ( Kang et al, 2021 ), metabolism ( Wang et al, 2021a ), and improve cardiovascular system ( Wang et al, 2021b ; Sarhene et al, 2021 ) and nervous system ( Brioschi Guevara et al, 2021 ) function, whereas most attention has been focused on the ginsenoside Rd.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation, Pharmacokinetics, and Pharmacological Activities of Ginsenoside Rd Against Multiple Diseases

Huang

Yao

et al. 2022

Front. Pharmacol.

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Panax ginseng C.A. Mey. has a history of more than 4000 years and is widely used in Asian countries. Modern pharmacological studies have proved that ginsenosides and their compounds have a variety of significant biological activities on specific diseases, including neurodegenerative diseases, certain types of cancer, gastrointestinal disease, and metabolic diseases, in which most of the interest has focused on ginsenoside Rd. The evidentiary basis showed that ginsenoside Rd ameliorates ischemic stroke, nerve injury, cancer, and other diseases involved in apoptosis, inflammation, oxidative stress, mitochondrial damage, and autophagy. In this review, we summarized available reports on the molecular biological mechanisms of ginsenoside Rd in neurological diseases, cancer, metabolic diseases, and other diseases. We also discussed the main biotransformation pathways of ginsenoside Rd obtained by fermentation.

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Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng

Cited by 5 publications

References 30 publications

Ginseng and “Shanghuo” (fireness): a comprehensive review from the viewpoints of TCM theory and modern science

Ginseng and “Shanghuo” (fireness): a comprehensive review from the viewpoints of TCM theory and modern science

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease

Biotransformation, Pharmacokinetics, and Pharmacological Activities of Ginsenoside Rd Against Multiple Diseases

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