Effect of Crushing Peanuts on Fatty Acid and Phenolic Bioaccessibility: A Long-Term Study

Parilli-Moser, Isabella; Domínguez-López, Inés; Arancibia-Riveros, Camila; Marhuenda-Muñoz, María; Vallverdú‐Queralt, Anna; Hurtado-Barroso, Sara; Lamuela‐Raventós, Rosa M.

doi:10.3390/antiox11020423

Cited by 8 publications

(6 citation statements)

References 77 publications

(84 reference statements)

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“…More than half of the total lipid content in peanuts is composed of oleic acid, which is linked to better cardiovascular health (33,34). In addition, peanuts contain specific very-longchain saturated fatty acids (arachidic, behenic and lignoceric acids) that have been inversely associated with the risk of cardiovascular diseases and diabetes (35,36) and we have previously found that participants from the ARISTOTLE study significantly increased the levels of these fatty acids in plasma after 6 months consuming peanut products (37,38). Moreover, peanuts are also a good source of bioactive compounds known to be protective against cardiovascular diseases, including magnesium, folate and phytochemicals such as polyphenols and phytosterols (2).…”

Section: Discussionmentioning

confidence: 99%

Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis

et al. 2022

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Although numerous studies have reported the protective effect of nut consumption on cardiovascular risk, evidence for the role of peanuts in maintaining cardiometabolic health is inconclusive. Presented here are the results from the ARISTOTLE study, a parallel randomized controlled trial evaluating the impact of regular peanut intake on anthropometric, biochemical, and clinical measurements. The 63 healthy subjects that completed the study consumed their habitual diet plus either: a) 25 g/day of skin roasted peanuts (SRP, n = 21), b) two tablespoons (32 g)/day of peanut butter (PB, n = 23) or c) two tablespoons (32 g)/day of a control butter based on peanut oil (CB, n = 19) for 6 months. In addition, a meta-analysis of clinical trials, including data from the ARISTOTLE study, was carried out to update the evidence for the effects of consuming peanuts, including high-oleic peanuts, and peanut butter on healthy subjects and those at high cardiometabolic risk. After a systematic search on PubMed, Web of Science, Cochrane Library and Scopus databases up to July 2021, 11 studies were found to meet the eligibility criteria. In the ARISTOTLE study, lower total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were found in the SRP group compared to the CB group (p = 0.019 and p = 0.008). The meta-analysis of clinical trials revealed that peanut consumption is associated with a decrease in triglycerides (MD: −0.13; 95% CI, −0.20 to −0.07; p < 0.0001) and that healthy consumers had lower total cholesterol and LDL-cholesterol/HDL-cholesterol ratios compared to the control groups (MD: −0.40; 95% CI, −0.71 to −0.09; p = 0.01 and MD: −0.19; 95% CI, −0.36 to −0.01; p = 0.03, respectively). However, individuals at high cardiometabolic risk experienced an increase in body weight after the peanut interventions (MD: 0.97; 95% CI, 0.54 to 1.41; p < 0.0001), although not in body fat or body mass index. According to the dose-response analyses, body weight increased slightly with higher doses of peanuts. In conclusion, a regular consumption of peanuts seems to modulate lipid metabolism, reducing triglyceride blood levels.Systematic Review Registrationhttps://osf.io/jx34y/, identifier: 10.17605/OSF.IO/MK35Y.

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Section: Discussionmentioning

confidence: 99%

Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis

et al. 2022

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“…To date, few studies have investigated the bioavailability of peanut polyphenols. In a recent study published by our group, we showed that the most abundant polyphenols in the two intervention products (SRP and PB) are p -coumaric and isoferulic acid [ 19 ]. In a comparative study with tree nuts, Rocchetti et al found the total phenolic content was highest in peanuts, especially phenolic acids such as 3,4-dihydroxyphenylacetic, 4-hydroxybenzoic, and protocatechuic acids, after in vitro fecal fermentation [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…The wide range of nutrients and bioactive compounds found in peanuts include fiber, folate, and arginine [ 13 , 16 ], and also, they are a well-known source of antioxidants such as polyphenols, whose concentration have been reported to be highest in their skins [ 17 , 18 ]. Phenolic acids, mainly p -coumaric and isoferulic acids, were the most abundant polyphenols found in skin roasted peanuts and peanut butter with skin added, representing more than 60–70% of the total polyphenols [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers

et al. 2023

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Phenolic compounds in peanuts may moderate inflammation and endothelial function. Thus, the aim of this study was to evaluate the association of urinary phenolic metabolites (UPMs) with vascular biomarkers after peanut product consumption. A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults who consumed 25 g/day of skin roasted peanuts (SRP), 32 g/day of peanut butter (PB), or 32 g/day of a control butter for six months. UPMs were analyzed by liquid chromatography coupled to mass spectrometry. Additionally, urinary eicosanoids, prostacyclin I2 (PGI2), and thromboxane A2 (TXA2) were determined using two competitive enzyme-linked immunosorbent assay kits. Consumers of SRP and PB presented significantly higher excretion of UPMs (enterodiol glucuronide (p = 0.018 and p = 0.031), 3-hydroxybenzoic acid (p = 0.002 and p < 0.001), vanillic acid sulfate (p = 0.048 and p = 0.006), p-coumaric acid (p = 0.046 and p = 0.016), coumaric acid glucuronide I (p = 0.001 and p = 0.030) and II (p = 0.003 and p = 0.036), and isoferulic acid (p = 0.013 and p = 0.015) in comparison with the control group. An improvement in PGI2 (p = 0.037) levels and the TXA2:PGI2 ratio (p = 0.008) was also observed after the peanut interventions compared to the control. Interestingly, UPMs with significantly higher post-intervention levels were correlated with an improvement in vascular biomarkers, lower TXA2 (r from −0.25 to −0.48, p < 0.050) and TXA2:PGI2 ratio (r from −0.25 to −0.43, p < 0.050) and higher PGI2 (r from 0.24 to 0.36, p < 0.050). These findings suggest that the UPMs with higher excretion after peanut product consumption could have a positive impact on vascular health.

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“…Along with peanuts, peanut butter is also a balanced source of protein that is especially useful for NAFLD patients, as they have many dietary restrictions. One of the most powerful antioxidants in peanut butter is coumaric acid [ 68 ]—and a study found that its activity is increased by 22% if the peanuts are roasted before turning them into butter. Peanuts also contain resveratrol, an antioxidant that has been shown to have anti-cancer effects and may lower the risk of obesity, heart disease and cognitive decline.…”

Section: Potential Bioactive Nutrients That May Interfere With Nafldmentioning

confidence: 99%

The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

Munteanu

Schwartz

2023

Antioxidants

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In the current review, we focused on identifying aliment compounds and micronutrients, as well as addressed promising bioactive nutrients that may interfere with NAFLD advance and ultimately affect this disease progress. In this regard, we targeted: 1. Potential bioactive nutrients that may interfere with NAFLD, specifically dark chocolate, cocoa butter, and peanut butter which may be involved in decreasing cholesterol concentrations. 2. The role of sweeteners used in coffee and other frequent beverages; in this sense, stevia has proven to be adequate for improving carbohydrate metabolism, liver steatosis, and liver fibrosis. 3. Additional compounds were shown to exert a beneficial action on NAFLD, namely glutathione, soy lecithin, silymarin, Aquamin, and cannabinoids which were shown to lower the serum concentration of triglycerides. 4. The effects of micronutrients, especially vitamins, on NAFLD. Even if most studies demonstrate the beneficial role of vitamins in this pathology, there are exceptions. 5. We provide information regarding the modulation of the activity of some enzymes related to NAFLD and their effect on this disease. We conclude that NAFLD can be prevented or improved by different factors through their involvement in the signaling, genetic, and biochemical pathways that underlie NAFLD. Therefore, exposing this vast knowledge to the public is particularly important.

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Effect of Crushing Peanuts on Fatty Acid and Phenolic Bioaccessibility: A Long-Term Study

Cited by 8 publications

References 77 publications

Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis

Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis

Urinary Phenolic Metabolites Associated with Peanut Consumption May Have a Beneficial Impact on Vascular Health Biomarkers

The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

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