Effect of crude protein reduction in blood, performance, immunological, and intestinal histological parameters of broiler chickens

Kuritza, Leandro Nagae; Almeida, Lúcia Massutti de; Santos, Marley Conceição dos; Bassi, Lucas Schmidt; Sonálio, Katiucia Cristine; Maiorka, Alex; Oliveira, Simone Gisele de

doi:10.1111/asj.13716

Cited by 4 publications

(4 citation statements)

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“…This loss may be related to the negative impact of the reduced protein on intestinal morphology, the physical limitations of the gut, 30 and the lower serum IGF-1 concentration, 8 and attributed to the lack of non-specific nitrogen needed to synthesize non-EAA, in agreement with previous studies. [3][4][5]13,30,31 Our result confirms that, in agreement with earlier studies, 9,13,32 the LLPD treatment reduced BWG and increased FCR in broilers. This indicates that the plasma and intracellular levels of leucine were below the minimum needed for protein accretion.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, the LPD treatment led to a loss in growth performance during both the starter and finisher phases. This loss may be related to the negative impact of the reduced protein on intestinal morphology, the physical limitations of the gut, 30 and the lower serum IGF‐1 concentration, 8 and attributed to the lack of non‐specific nitrogen needed to synthesize non‐EAA, in agreement with previous studies 3‐5,13,30,31 …”

Section: Discussionsupporting

confidence: 89%

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Beta‐hydroxy‐β‐methyl butyrate‐supplemented diet for broiler chickens is more conducive to dietary protein reduction than a leucine‐supplemented diet until 21 days old

Kop Bozbay,

Yılmaz,

Ocak

2023

J Sci Food Agric

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BACKGROUNDDietary L‐leucine or its metabolite 𝛽‐hydroxy‐𝛽‐methylbutyrate (HMB) has a crucial role in the muscle protein metabolism of broilers during the first few‐week growing period. This study aimed to evaluate the effects of L‐leucine (LLPD) or HMB (HLPD) supplementation in a low‐protein diet (20%, LPD) until 21 days old on performance, carcass weight, muscle yield, and meat quality, as well as intestinal morphometry in broiler chickens.RESULTSFrom d 1 to 42, LPD decreased body weight gain (BWG) and feed intake (FI) and increased feed conversion ratio (FCR) compared to a standard protein diet (22%, SPD). The LLPD and HLPD did not affect FI, but the LLPD decreased the BWG and increased the FCR compared to the SPD. The LPD group had lower body and muscle weights than other groups. Compared to LPD, HLPD increased dressing percentage. The LPD decreased the serum IGF‐1 content compared to the SPD and LLPD. The duodenal villus height of the LPD and LLPD broilers was smaller than those of the SPD and HLPD birds. The HLPD broilers had lower duodenal villus width than the SPD birds. The duodenal crypt depth and ileal mucosal thickness were higher in the HLPD group than in other groups. The HLPD and LLPD enhanced the ileal villus height compared to the SPD. The LLPD and HLPD treatments did not affect meat quality traits compared to the SPD treatment.CONCLUSIONDietary HMB could be a conducive approach to reducing dietary protein for broilers until 21 days old.This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Beta‐hydroxy‐β‐methyl butyrate‐supplemented diet for broiler chickens is more conducive to dietary protein reduction than a leucine‐supplemented diet until 21 days old

Kop Bozbay,

Yılmaz,

Ocak

2023

J Sci Food Agric

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“…In addition, uric acid can also become elevated due to dietary nucleic acids, which indicates a toxicological effect ( Kiarie et al., 2020 ). Interestingly, there has been a proven relationship in poultry with higher CP levels decreasing the blood uric acid levels linearly, which was not the case in this trial ( Kuritza et al, 2022 ). Thus, the increased uric acid levels observed under ETY diets may result from increased calcium absorption and improved absorption of nucleic acids.…”

Section: Discussionmentioning

confidence: 68%

Egg production, egg quality, organ weight, bone ash, and plasma metabolites in 30-week-old Lohmann LSL lite hens fed corn and soybean meal-based diets supplemented with enzymatically treated yeast

Cloet¹,

Maina²,

Schulze³

et al. 2023

Poultry Science

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“…The detrimental effect of low-CP diets on intestinal morphology may be due to the lower content of non-essential AAs which efficiently sustains the intestinal epithelial layer [ 47 ]. Recently, Kuritza et al [ 48 ] observed a reduction in performance and diminished intestinal histological measurements, including villus, crypt, and goblet cells, in broiler chickens fed with low-CP diets (1–3 fewer CP percentage units).…”

Section: Discussionmentioning

confidence: 99%

Impacts of Dietary Lysine and Crude Protein on Performance, Hepatic and Renal Functions, Biochemical Parameters, and Histomorphology of Small Intestine, Liver, and Kidney in Broiler Chickens

Mousa

Asman

Ali

et al. 2023

Veterinary Sciences

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The present study aimed to investigate the effects of increasing dietary lysine (Lys) levels with an adequate dietary crude protein (CP) content, as well as the effects of a reduction in dietary CP content with the recommended amino acid (AAs) level, on the performance, blood biochemical parameters, and histomorphology of the duodenum, liver, and kidney in broiler chickens. A total of 500 broiler chickens were randomly distributed into five dietary treatment groups, following a completely randomized design, where, at the beginning, the control group (C) was fed a diet containing the standard CP and Lys levels: 23% CP with 1.44% Lys during the starter period; 21.5% CP with 1.29% Lys during the growing period; and 19.5% CP with 1.16% Lys during the finishing period. The Lys content was increased by 10% above the recommended control basal requirements in the second group (Gr1) and by 20% in the third group (Gr2), while using the same recommended CP percentage as the C group. The fourth group (Gr3) had a 1% lower CP content and the fifth group had a 2% lower CP content than the C group, with the same recommended AA level as the C group. Increasing the Lys content in the Gr1 group improved the broilers’ weight gains (p < 0.05) during the starter, growing, and finishing periods. Decreasing dietary CP with the standard AA levels (Gr3 and Gr4) did not significantly affect (p > 0.05) the live weight gain, feed intake, or feed conversion ratio (FCR) of the broilers compared with those fed with the C diet. Blood total bilirubin, direct and indirect bilirubin, triglycerides, cholesterol, low-density lipoprotein (LDL), and very LDL were not different among the experimental groups. However, blood aspartate aminotransferase levels were increased (p < 0.05) in the Gr1 and Gr3 groups compared with the other treatment groups. All dietary treatments decreased the serum creatinine levels (p < 0.05) compared with the C group. The Gr2 broilers had greater serum total protein and globulin (p < 0.05) than those receiving the other treatments. Increasing dietary Lys levels resulted in a significant improvement in duodenum villus height and width (p < 0.05), while the low-CP diets resulted in shorter villi length and width, along with degenerated areas and lymphocytic infiltration. Low dietary CP content induced hepatocyte disorganization and moderate degeneration, along with vacuolated hepatic cells, excessive connective tissue, and lymphocytic infiltration. The cortical regions of the kidney exhibited obvious alterations in the Gr3 and Gr4 groups and large interstitial spaces were found between tubules. Renal tubules in the Gr3 and Gr4 groups were smaller in size and some of these tubules were atrophied. In conclusion, reducing dietary CP levels to 1% or 2% lower than the recommended level did not negatively affect growth performance, inducing minimal influence on the blood metabolic indicators of health status, and resulting in moderate alterations to the histomorphology of the duodenum, liver, and kidney. Furthermore, increasing the Lys content by 10% above the recommended level improved the growth performance, health status, and histomorphology of the duodenum, liver, and kidney in broiler chickens.

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Effect of crude protein reduction in blood, performance, immunological, and intestinal histological parameters of broiler chickens

Abstract: We aimed to evaluate the effects of the reduction in dietary crude protein (CP) on blood urea, uric acid, performance, immunity, and intestinal histology of broilers. Four

Cited by 4 publications

References 44 publications

Beta‐hydroxy‐β‐methyl butyrate‐supplemented diet for broiler chickens is more conducive to dietary protein reduction than a leucine‐supplemented diet until 21 days old

Beta‐hydroxy‐β‐methyl butyrate‐supplemented diet for broiler chickens is more conducive to dietary protein reduction than a leucine‐supplemented diet until 21 days old

Egg production, egg quality, organ weight, bone ash, and plasma metabolites in 30-week-old Lohmann LSL lite hens fed corn and soybean meal-based diets supplemented with enzymatically treated yeast

Impacts of Dietary Lysine and Crude Protein on Performance, Hepatic and Renal Functions, Biochemical Parameters, and Histomorphology of Small Intestine, Liver, and Kidney in Broiler Chickens

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