Effect of Crude Methanol Extract of<i>Terminalia avicennioides</i>in Normal Gastric/Histamine-Induced HCl Secretions in Rats

Terminalia avicennioides Guill. & Perr. (Combretaceae) is used traditionally to treat malaria in Nigeria. To establish its efficacy, methanolic extract of T. avicennioides bark was investigated for antimalarial activity against Plasmodium berghei (NK-65) in mice. Twenty-five mice in five groups were used for this study. Group 1 was uninfected normal control. Twenty mice infected with P. berghei were grouped as untreated negative control (group 2), 5 mg/kg b.w. p.o. artesunate-treated positive control (group 3), and 100 and 200 mg/kg b.w. p.o. T. avicennioides-treated infected mice (groups 4 and 5, respectively). Four-day suppressive effects on P. berghei and hematological and oxidative statuses of the mice were assessed. Suppression of parasitemia by artesunate and methanolic extract of T. avicennioides (at 100 and 200 mg/kg b.w.) after 1 day of treatment was 10, 18, and 11% respectively; at day 5, the level of suppression was 77, 82, and 84% respectively. P. berghei infection decreased hemoglobin, red blood cell, and lymphocyte counts and increased neutrophil count; artesunate and medicinal plant treatment restored these parameters to normal control levels. Also, artesunate and medicinal plant treatment of infected mice significantly (p < 0.05) increased serum and liver superoxide dismutase activities and significantly (p < 0.05) reduced serum malondialdehyde concentration compared to untreated infected mice. The antimalarial effect of T. avicennioides is comparable to that of artesunate. The restoration of oxidative and hematological statuses, to normal values by T. avicennioides, may provide better protection against the malaria severity and complications.

show abstract

Antimalarial, hematological, and antioxidant effects of methanolic extract of Terminalia avicennioides in Plasmodium berghei-infected mice

Omonkhua

Cyril-Olutayo

Akanbi

et al. 2013

Parasitol Res

View full text Add to dashboard Cite

show abstract

Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer

Bahramikia,

Izadi

2023

Inflammopharmacol

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effect of Crude Methanol Extract ofTerminalia avicennioidesin Normal Gastric/Histamine-Induced HCl Secretions in Rats

Cited by 2 publications

References 17 publications

Antimalarial, hematological, and antioxidant effects of methanolic extract of Terminalia avicennioides in Plasmodium berghei-infected mice

Antimalarial, hematological, and antioxidant effects of methanolic extract of Terminalia avicennioides in Plasmodium berghei-infected mice

Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer

Contact Info

Product

Resources

About