Effect of crosslinking agents on drug distribution in chitosan hydrogel for targeted drug delivery to treat cancer

Uddin, Salah; Ju, Jaehyung

doi:10.1007/s10965-020-02059-8

Cited by 16 publications

(13 citation statements)

References 53 publications

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“…It has been widely considered as one of the safest biomaterials for various biomedical applications [10][11][12]. Chitosan-based materials have been studied so far as drug delivery systems [13,14], biomedical applications [10][11][12]. Chitosan-based materials have been studied so far as drug delivery systems [13,14], and wound dressings [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan-based materials have been studied so far as drug delivery systems [13,14], biomedical applications [10][11][12]. Chitosan-based materials have been studied so far as drug delivery systems [13,14], and wound dressings [15,16]. Also, these materials have been used for scaffold manufacturing in tissue engineering [17][18][19][20], and as dietary supplements in the body mass reduction as well as the cholesterol-lowering formulations [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide–dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox® test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Węgrzynowska-Drzymalska

Grebicka

Mlynarczyk

et al. 2020

Materials

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“…In another word, it shows that a stiff hydrogel has a large resistance to external environmental influences and subsequently a lower swelling ratio. [43] Figure 6c displays the effect of temperature on the equilibrium swelling of pHEMA hydrogels. The 30H-NOX-3D, 30H-TEG-3D and 30H-CNC-3D hydrogels show a slightly decrease of the swelling ratio at temperatures higher than 65 °C.…”

Section: Resultsmentioning

confidence: 99%

“…The swelling ratio is in‐line with the trend of their tensile modulus, i. e., the larger tensile modulus, the lower swelling ratio. In another word, it shows that a stiff hydrogel has a large resistance to external environmental influences and subsequently a lower swelling ratio [43] …”

Section: Resultsmentioning

confidence: 99%

Toughened Hydrogels for 3D Printing of Soft Auxetic Structures

Pruksawan

Chee

Wang

et al. 2022

Chemistry An Asian Journal

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Materials with negative Poisson's ratio have attracted considerable attention and offered high potential applications as biomedical devices due to their ability to expand in every direction when stretched. Although negative Poisson's ratio has been obtained in various base materials such as metals and polymers, there are very limited works on hydrogels due to their intrinsic brittleness. Herein, we report the use of methacrylated cellulose nanocrystals (CNCMAs) as a macro-cross-linking agent in poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogels for 3D printing of auxetic structures. Our developed CNCMA-pHEMA hydrogels exhibit significant improvements in mechanical properties, which is attributed to the coexistence of multiple chemical and physical interactions between the pHEMA and CNCMAs. Structures printed by using CNCMA-pHEMA hydrogels show auxetic behavior with greatly enhanced toughness and stretchability compared to the hydrogel with a traditional cross-linking agent. Such strong and tough auxetic hydrogels would contribute toward establishing advanced flexible implantable devices such as biodegradable oesophageal self-expandable stents.

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“…Most of the administered chemotherapy drugs are not distributed, particularly in an intended tissue, which leads to normal cell toxicity. 1,2 Currently, liposomal drug delivery systems (LDDSs) are being exploited to hinder the complication mentioned above. 3,4 Despite its usefulness in drug delivery compared to conventional drug administration, it still has some disadvantages, including random drug leakage at variable rates.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

et al. 2021

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Introduction: The cytotoxicity of chemotherapy drugs is a significant challenge in the way of surmounting cancer. Liposomal drug delivery has proven to be efficacious in increasing the function of the drugs. Its potential to accumulate drugs in the target site and enhance the efficiency of anti-cancer agents with lower doses hinders their cytotoxicity on normal healthy cells. Since the release of drugs from liposomes is not generally on a controlled basis, several studies have suggested that external stimuli including lasers could be used to induce controlled release and boost the efficiency of liposomal drug delivery systems (LDDSs). Methods: The A375 cancer cell line was used and exposed to the liposomes containing doxorubicin in the presence of a low-level laser beam to investigate its effect on the liposomal stimuli-responsiveness release and its toxicity on cancer cells. So as to achieve that goal, Annexin V/PI was employed to analyze the number of cells that underwent apoptosis and necrosis. Results: Here, we report the effect of laser irradiation on LDDSs. According to the results obtained from the annexin V/PI assay, the pattern of viability status has shifted, so that the number of pre-apoptotic cells treated with liposomal doxorubicin and a laser beam was more than that of cells treated with only liposomal doxorubicin. Conclusion: The use of stimuli-responsive LDDSs, in this case, laser-responsive, has led to favorable circumstances in the treatment of cancer, offering enhanced cancer cell cytotoxicity.

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Effect of crosslinking agents on drug distribution in chitosan hydrogel for targeted drug delivery to treat cancer

Cited by 16 publications

References 53 publications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Toughened Hydrogels for 3D Printing of Soft Auxetic Structures

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

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