Effect of Crocus sativus aqueous extract (saffron) on Schistosoma mansoni worms in experimentally infected mice

Abstract

Saffron Granuloma Antioxidants Worm SEMThe present study is designed to evaluate the therapeutic effect of Crocus sativus(saffron) aqueous extract (CSE) alone or in combination with praziquantel on Schistosoma mansoni infected mice. Parasitological, immunological, pathological and immunohistochemical parameters and surface topography of worms were determined. Treatment of S. mansoni infected mice with saffron or PZQ revealed a significant reduction in worm burden, hepatic and intestinal ova count with a decline in granuloma diameter. There was an increase in total IgG and IL-10 blood levels after treatment with PZQ and/or CSE. Superoxide dismutase (SOD) and catalase levels were improved in infected mice treated with CSE in comparison with infected mice. Male worm surface ultrastructure examination showed a swelling, rupture of numerous tubercles with marked decrease in spines and severe peeling of tegumental dorsal surfaces after treatment with saffron. In conclusion, administration of aqueous extract of Crocus sativus is effective treatment for S. mansoni infection.

Hepatoprotective Effect of Uncaria Tomentosa on Schistosoma Mansoni Experimental Infection Through Reduction of Nuclear Factor Kappa B

“…El-Lakkany et al (2012) recorded that silymarin a product of artichoke lost to PZQ and the best results achieved when the extract was combined with PZQ. Also, Shaaban et al (2019) reported that anti-schistosomal effect of PZQ was more efficient than Crocus sativus aqueous extract alone. However, other herbs extract recorded antiparasitic effects as Pomegranata granatum, Commophora molmol extracts Allium sativum, A. cepa, Schitozim, Artemisia absinthium, Tanacetum parthenium, A. sativum clove, Zingiber officinale, , Lavendula dentata L., Thymus capitatus L. and T. bovei (El-Sherbini et al, 2009;Mantawy et al, 2011;El-Hela et al, 2013;Allan et al, 2014;de Almeida et al, 2016).…”

In vitro Assessment of Antischistosomal Effect of the Marine Hyrtios sp. Sponge Extract against Schistosoma mansoni Adult Worms

“…Additionally, the worm's ability to select an appropriate attachment site during feeding is impacted by the elimination of the sensory papillae on the oral sucker (Reda et al, 2019). Additionally, tegumental damage may affect the tegumental functions, causing damage to the defensive mechanism in the worm, and therefore, it could be easily targeted by the host's immune system (Xiao et al, 2000;Kamel & El-Shinnawy, 2015;Shaaban et al, 2019).…”