Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt

Sanabrais-Jiménez, Marco Antonio; Sotelo-Ramírez, Carlo E; Ordoñez-Martinez, B.; Jiménez-Pavón, Joanna; Ahumada-Curiel, G.; Piana-Diaz, S.; Flores-Flores, G.; Flores‐Ramos, Mónica; Jiménez-Anguiano, Anabel; Camarena, Beatríz

doi:10.1007/s00702-019-01991-4

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…Recently, O'Connor et al [52] investigated the effects of childhood trauma, daily stress, and emotions on daily cortisol levels in individuals vulnerable to suicidal behavior and found that childhood trauma was associated with dysregulated cortisol reactivity to stress in adulthood. Sanabrais-Jiménez et al [55], in a study of 366 patients with affective disorders (of which 183 were at risk of suicide), demonstrated an interaction between CRHR1 and CRHR2 with childhood trauma in patients with a history of suicidal acts, highlighting the relationship between the CRHR1 and CRHR2 genes with childhood trauma and suicide risk.…”

Section: Early Life Stress Hpa-axis Dysregulation and Suicidementioning

confidence: 99%

The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

et al. 2020

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Stress and Hypothalamic–Pituitary–Adrenal (HPA) axis dysregulation play a major role in various pathophysiological processes associated with both mood disorders and suicidal behavior. We conducted a systematic review with the primary aim of clarifying the nature and extent of HPA axis activity and suicidal behavior. The second aim of this review was to investigate whether potential biomarkers related to HPA axis abnormalities act as individual susceptibility factors for suicide. The PRISMA statement for reporting systematic reviews was used. Only articles published in English peer-reviewed journals were considered for possible inclusion; we excluded case reports, meta-analyses, and systematic reviews, and studies that did not clearly report statistical analysis, diagnostic criteria, or the number of patients included. Overall, 36 articles on HPA axis and suicide risk met inclusion criteria and were reviewed. Studies that investigated tests detecting biomarkers and the role of early life stressors in suicide risk were also included. We found that HPA axis activity is involved in suicide risk, regardless of the presence or absence of psychiatric conditions. The HPA axis abnormalities, mainly characterized by hyperactivity of the HPA axis, may exert an important modulatory influence on suicide risk. Impaired stress response mechanisms contribute to suicide risk. Targeting HPA axis dysregulation might represent a fruitful strategy for identifying new treatment targets and improving suicide risk prediction.

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Section: Early Life Stress Hpa-axis Dysregulation and Suicidementioning

confidence: 99%

The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

et al. 2020

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“…Alterations in stress-induced regulation via any genetic factor could have important influences on SB. Some stress pathways genes that have been studied in SB include NR3C1, [19,20]; FKBP5 [21,22]; CRHR1 [23,24]; and SKA2 gene [25,26]. Candidate gene studies have shown differentially expressed mRNA patterns and single-nucleotide polymorphisms (SNPs) in Caucasian and African American populations associated with SB [27,28].…”

Section: Figurementioning

confidence: 99%

“…Sixteen studies [19,23,24,27,28,31,38,42,[44][45][46][47][48][49][50][51] evaluated the association between the CRHR1 SNPs and SB phenotypes in 3718 cases and 4539 controls. Significant associations were identified between s7209436, rs110402, rs16940665, rs4792887, rs12936511, rs1396862, rs878886, and rs242948 SNPs and SB.…”

Section: Crhr1 Genementioning

confidence: 99%

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Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

Hernández‐Díaz

Genis‐Mendoza

González-Castro

et al. 2021

Genes

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Background: Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis—stress pathway and SB through a systematic review. Methods: We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB. Results: A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. Conclusions: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.

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“…Karanovic et al (2017) reported the interacting effect of TPH2 and ADARB1 variants with child abuse in predisposition to SA. Sanabrais-Jiménez et al (2019) suggested that genetic variants of CRHR1 and CRHR2 genes interact with childhood trauma, mainly physical negligence, and emotional and sexual abuse to develop SA. It has been shown that a psychiatric genetic risk factor DN-DISC1 modulates the neurobehavioral effects of chronic Toxoplasma infection in a sex-dependent manner (Kannan et al, 2018).…”

Section: E T T E R T O T H E E D I T O R Insufficient Evidential Basis For the Association Between Toxoplasma Gondii And Suicide Attemptsmentioning

confidence: 99%

Insufficient evidential basis for the association between Toxoplasma gondii and suicide attempts

Chen

2021

Transbound Emerg Dis

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Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt

Cited by 10 publications

References 41 publications

The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk

Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

Insufficient evidential basis for the association between Toxoplasma gondii and suicide attempts

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