Effect of creatine supplementation and drop-set resistance training in untrained aging adults

Johannsmeyer, Sarah; Candow, Darren G.; Brahms, Clemens Markus; Michel, Deborah; Zello, Gordon A.

doi:10.1016/j.exger.2016.08.005

Cited by 38 publications

(36 citation statements)

References 35 publications

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“…Creatine supplementation protocols used both relative (to body mass) and absolute dosing strategies with and without a loading phase (e.g., 20 grams for five to seven days). Training volume increased with creatine supplementation compared to placebo in two studies [24,25], while several others reported no differences between groups [22,23,[26][27][28][29][30]. In addition, dietary intake (energy intake or protein) did not differ between groups [21][22][23][24][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Section: Resultsmentioning

confidence: 99%

Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis

Forbes

Candow

Krentz

et al. 2019

JFMK

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Aging is associated with an increase in fat mass which increases the risk for disease, morbidity and premature mortality. Creatine supplementation in combination with resistance training has been shown to increase lean tissue mass in adults ≥50 years of age; however, the synergetic effects of creatine and resistance training on fat mass in this population are unclear. Creatine metabolism plays an important role in adipose tissue bioenergetics and energy expenditure. Thus, the combination of creatine supplementation and resistance training may decrease fat mass more than resistance training alone. The purpose of this review is two-fold: (1) to perform meta-analyses on studies involving creatine supplementation during resistance training on fat mass in adults ≥50 years of age, and (2) to discuss possible mechanistic actions of creatine on reducing fat mass. Nineteen studies were included in our meta-analysis with 609 participants. Results from the meta-analyses showed that adults ≥50 years of age who supplemented with creatine during resistance training experienced a greater reduction in body fat percentage (0.55%, p = 0.04) compared to those on placebo during resistance training. Despite no statistical difference (p = 0.13), adults supplementing with creatine lost ~0.5 kg more fat mass compared to those on placebo. Interestingly, there are studies which have linked mechanism(s) explaining how creatine may influence fat mass, and these data are also discussed.

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Section: Resultsmentioning

confidence: 99%

Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis

Forbes

Candow

Krentz

et al. 2019

JFMK

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“…Females may not experience the same gains in muscle mass and strength following creatine supplementation and resistance training compared to males (Johannsmeyer et al, 2016;Tarnopolsky & Maclennan, 2000). Although speculative, females may have higher initial intramuscular creatine stores (free creatine and PCr) than males which make them less responsive to supplementation (Forsberg et al, 1991;Johannsmeyer et al, 2016;Tarnopolsky, 2000). Furthermore, creatine appears to have no effect on muscle protein kinetics in females (Parise et al, 2001).…”

Section: Sex Differencesmentioning

confidence: 99%

Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males

Bernat

Candow

Gryzb

et al. 2019

Appl. Physiol. Nutr. Metab.

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The purpose was to investigate the effects of high-velocity resistance training (HVRT) and creatine supplementation in untrained healthy aging males. Participants were randomized to supplement with creatine (0.1 g·kg−1·day−1 of creatine + 0.1 g·kg−1·day−1 of maltodextrin) or placebo (0.2 g·kg−1·day−1 of maltodextrin) during 8 weeks of HVRT. Prior to and following HVRT and supplementation, assessments were made for muscle strength, muscle thickness, peak torque, and physical performance. There was a significant increase over time for all measures of muscle strength (p < 0.001), muscle thickness (p < 0.001), and some measures of peak torque (knee flexion; 1.05 and 3.14 rad/s; p < 0.001) and physical performance (balance board time-to-completion; p = 0.017). There was a group × time interaction for leg press strength (p = 0.044) and total lower-body strength (leg press, knee flexion, knee extension combined; p = 0.039). The creatine group experienced greater gains in leg press and total lower-body strength compared with the placebo group, with no other differences. HVRT increases muscle strength, muscle thickness, and some measures of peak torque and physical performance in untrained healthy aging males. The addition of creatine supplementation to HVRT further augments the gains in leg press and total lower-body strength. Novelty High-velocity resistance training increases muscle mass and performance. Creatine supplementation increases lower-body muscle strength. High-velocity resistance training and creatine supplementation are safe interventions for aging adults.

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“…Furthermore, females were assessed in the study by Aoki whereas we assessed only males. Previous studies have shown differences in muscle fatigability [6,8,19] and responsiveness to creatine supplementation between sexes [20,21].…”

Section: Discussionmentioning

confidence: 97%

Effects of Creatine Supplementation on Lower-Limb Muscle Endurance Following an Acute Bout of Aerobic Exercise in Young Men

Vieira

Paula

Gentil

et al. 2020

Sports

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We aimed to determine whether creatine supplementation influences lower-limb muscle endurance following an acute bout of aerobic exercise (AE) in young healthy men. Using a randomized, double-blind, placebo-controlled crossover design, 11 men (26.5 ± 6.2 years, body mass index 26.6 ± 2.1 kg/m2),with 12 months of experience in strength training (three times/week) and AE (two times/week) were randomized to receive creatine (20 g/day plus 20 g/day maltodextrin) and placebo (40 g/day maltodextrin) for 7 days, separated by a washout period of 14 days, before performing an acute bout of AE (30 min on treadmill at 80% baseline maximum velocity) which was followed by four sets of bilateral leg extension endurance exercise using a 10-repetition maximum protocol (10 RM)). There was a significant decrease in the number of repetitions performed in the third (Placebo: −20% vs. Creatine: −22%) and fourth set (Placebo: −22% vs. Creatine: −28%) compared with the first set (p < 0.05), with no differences between creatine and placebo. Additionally, no differences were observed between creatine and placebo for the total number of repetitions performed across all four sets (Placebo: 33.9 ± 7.0 vs. Creatine: 34.0 ± 6.9 repetitions, p = 0.97), nor for total work volume (Placebo: 3030.5 ± 1068.2 vs. Creatine: 3039.8 ± 1087.7 kg, p = 0.98). Short-term creatine supplementation has no effect on lower-limb muscle endurance following an acute bout of aerobic exercise in trained young men.

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Effect of creatine supplementation and drop-set resistance training in untrained aging adults

Cited by 38 publications

References 35 publications

Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis

Changes in Fat Mass Following Creatine Supplementation and Resistance Training in Adults ≥50 Years of Age: A Meta-Analysis

Effects of high-velocity resistance training and creatine supplementation in untrained healthy aging males

Effects of Creatine Supplementation on Lower-Limb Muscle Endurance Following an Acute Bout of Aerobic Exercise in Young Men

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