Effect of Cream Bases on the Antimicrobial Properties of the Essential Oil of Aframomum meleguata

Igwilo, C. I.; Akpan, U. E.; Adeoye, A. O.; Ilozor, C. N.

doi:10.3109/13880209109082848

Cited by 4 publications

(1 citation statement)

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“…Te cream base used in this study is aqueous cream base while the ointment base used is simple ointment base. Te hydrophilicity or hydrophobicity nature of the cream base or ointment base, respectively, may be highly implicated in the antibacterial activity of these products [70]. Te aqueous cream base due to its hydrophilicity will allow faster and better difusion of the active ingredient to exert its activity.…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Adeleye,

Aremu,

Iqbal

et al. 2023

Journal of Nanotechnology

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Objectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with aqueous and methanol extract of Ehretia cymosa leaf and to explore its antibacterial potentials in semisolid dosage delivery system as topical antibacterial cream and ointment. Methods. E. cymosa leaf was extracted by macerating in distilled water and methanol. The extracts were used to synthesize SNPs. SNPs were characterized and confirmed by visual observation, UV-visible spectroscopy, FTIR, atomic absorption spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. SNPs were used to formulate cream and ointment, and the antibacterial activity of the formulations was evaluated against Staphylococcus aureus and Escherichia coli. Results. Absorption band was observed at 450 nm for aqueous extract SNPs and 420 nm for methanol extract SNPs due to surface plasmon resonance. SNPs were agglomerated with the irregular size of 55 nm and 90 nm. The formulations had acceptable physicochemical properties with good drug-excipient compatibility. The antibacterial activity of cream formulations had a significantly ( p < 0.0001 ) higher antibacterial activity compared to ointment formulations. Both formulations with SNPs had higher antibacterial activity than ciprofloxacin. Conclusion. Cream and ointment formulations loaded with green synthesized E. cymosa leaf extract SNPs present a potential for a more efficient and effective antibacterial drug delivery to ameliorate the impact of antibacterial drug resistance.

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Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Adeleye,

Aremu,

Iqbal

et al. 2023

Journal of Nanotechnology

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Essential oil constituents ofAframomum melegueta (Roscoe) K. Schum. seeds (alligator pepper) from Nigeria

Ajaiyeoba

Ekundayo

1999

Flavour Fragr. J.

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The composition of the essential oil isolated from the seeds of Aframomum melegueta (Roscoe) K. Schum. by hydrodistillation was characterized by means of gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS). A total of 27 compounds constituting 98.6% of the volatile oil were identified. Two sesquiterpene hydrocarbons: humulene and caryophyllene made up 82.6% of the volatile oil, whilst their oxides amounted to a further 9.0%. Seventeen other mono‐ and sesquiterpenes accounted for only 1% of the volatile oil. Five non‐terpenoids were detected in trace amounts only (<0.2%). Of the 27 constituents identified, 12 are reported as components of A. melegueta for the first time. Copyright © 1999 John Wiley & Sons, Ltd.

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In vitro bactericidal activity of diterpenoids isolated from Aframomum melegueta K.Schum against strains of Escherichia coli , Listeria monocytogenes and Staphylococcus aureus

Ngwoke

Chevallier

Wirkom³

et al. 2014

Journal of Ethnopharmacology

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Effect of Cream Bases on the Antimicrobial Properties of the Essential Oil of Aframomum meleguata

Cited by 4 publications

References 1 publication

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Essential oil constituents ofAframomum melegueta (Roscoe) K. Schum. seeds (alligator pepper) from Nigeria

In vitro bactericidal activity of diterpenoids isolated from Aframomum melegueta K.Schum against strains of Escherichia coli , Listeria monocytogenes and Staphylococcus aureus

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