Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

Pirmoghani, Amin; Salehi, Iraj; Moradkhani, Shirin; Karimi, Seyed Asaad; Salehi, Sakineh

doi:10.1016/j.ibror.2019.10.004

Cited by 20 publications

(18 citation statements)

References 42 publications

(51 reference statements)

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“…The retention test was performed 24 h after the PAL acquisition trial. The rats were placed in the lighted chamber as in PAL training and 5 s later, the guillotine door was raised, and the STL in the retrieval test (STLr) and time in the dark compartment (TDC) were recorded for up to 600 s. If the rat did not enter the dark compartment within 300 s, the retention test was terminated and a ceiling score of 600 s was assigned (Pirmoghani et al , 2019; Habibitabar et al , 2020).…”

Section: Methodsmentioning

confidence: 99%

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

Karimi

Noorbakhsh

Komaki

et al. 2021

Behavioural Pharmacology

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There are reports regarding the effects of intracellular Ca2+ and synthesis and release of endocannabinoids. The secretion of endocannabinoids depends on the L-type calcium channel. The present study evaluated the involvement of the cannabinoid CB1 receptors in the effect of L-type calcium channel blocker verapamil on passive avoidance learning (PAL) in adult male rats. In this study, we examined the effects of an acute administration of the cannabinoid CB1 receptors antagonist/inverse agonist AM251 following a chronic administration of the Ca2+ channel blocker verapamil on PAL. Male Wistar rats were administered verapamil (10, 25 and 50 mg/kg) or saline intraperitoneally (i.p) daily for 13 days (n = 10/group). After this treatment period, a learning test (acquisition) was performed, and a retrieval test was performed the following day. The results indicated that chronic systemic administration of verapamil (in a dose-dependent manner) impaired memory acquisition and retrieval. Pre-training acute administration of a selective CB1 antagonist/inverse agonist, AM251 (5 mg/kg, i.p.) did not change memory acquisition and retrieval. Co-administration of the verapamil and AM251 significantly reversed verapamil-induced amnesia, suggesting a functional interaction between AM251 and verapamil. The results indicated the interactive effects of cannabinoid CB1 receptors and L-type calcium channel in passive avoidance learning and AM251 can counter the effects of verapamil on memory.

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Section: Methodsmentioning

confidence: 99%

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

Karimi

Noorbakhsh

Komaki

et al. 2021

Behavioural Pharmacology

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“…19 Memory deficits occurred in the model mice with diabetes, which also accompanied the pathologies in the liver and serum. 20 Thus, it is interesting whether the scopolamineinduced amnesia would lead to other pathological changes in the serum and liver. The levels of oxidative stress (Fig.…”

Section: Aph-ca Conjugates Reversed the Levels Of Oxidative Stress And Inflammatory Markers In The Serum And Livermentioning

confidence: 99%

“…It was known that the development of diabetes is accompanied by memory deficits, liver impairment, serum parameter disorders, and so on. 20 Importantly, the investigations of compounds that alleviated the memory deficits in AD, PD, or other related diseases were focused on pathological changes in the brain. However, the oxidative stress and inflammation in the serum and liver induced by scopolamine have been little investigated.…”

Section: Food and Function Papermentioning

confidence: 99%

Synergistic alleviation effects of anchovy hydrolysates-catechin on scopolamine-induced mice memory deficits: the exploration of the potential relationship among gut-brain-axis

Zhao

Zhang²,

Zhong

et al. 2022

Food Funct.

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“…A recent study evaluated the effects of CE supplementation on diabetes-induced T memory deficits and serum biochemical parameters in male rats. The results demonstrated that CE has lipid-lowering and hypoglycemic effects and improves memory in streptozotocin-induced diabetes [ 101 ]. A recent study in rats has confirmed the protective function of C. monogyna extracts against diabetes for treating hyperglycemia, oxidative stress and pancreatic tissue damage [ 141 ].…”

Section: Pharmaceutical Propertiesmentioning

confidence: 99%

Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegus monogyna Jacq.), Rosaceae

et al. 2021

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Hawthorn (Crataegus monogyna Jacq.) is a wild edible fruit tree of the genus Crataegus, one of the most interesting genera of the Rosaceae family. This review is the first to consider, all together, the pharmaceutical, phytochemical, functional and therapeutic properties of C. monogyna based on numerous valuable secondary metabolites, including flavonoids, vitamin C, glycoside, anthocyanin, saponin, tannin and antioxidants. Previous reviews dealt with the properties of all species of the entire genera. We highlight the multi-therapeutic role that C. monogyna extracts could have in the treatment of different chronic and degenerative diseases, mainly focusing on flavonoids. In the first part of this comprehensive review, we describe the main botanical characteristics and summarize the studies which have been performed on the morphological and genetic characterization of the C. monogyna germplasm. In the second part, the key metabolites and their nutritional and pharmaceutical properties are described. This work could be an essential resource for promoting future therapeutic formulations based on this natural and potent bioactive plant extract.

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Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

Abstract: Graphical abstract

Cited by 20 publications

References 42 publications

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

Synergistic alleviation effects of anchovy hydrolysates-catechin on scopolamine-induced mice memory deficits: the exploration of the potential relationship among gut-brain-axis

Botanical, Phytochemical, Anti-Microbial and Pharmaceutical Characteristics of Hawthorn (Crataegus monogyna Jacq.), Rosaceae

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