Effect of COVID-19 on Stress and Biomarkers: An Exploratory Cross-Sectional Study

Kumari, Amita; Itagi, Afreen Begum H; Rukadikar, Charushila A; Amudharaj, D; Naik, Bijaya Nanda; Juhi, Ayesha; Naik, Sunil G.; Dipankar, Satish

doi:10.7759/cureus.35702

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Specifically, the IL-6 level in the severe group was markedly higher than that in the moderate group was observed between the severe and mild COVID-19 groups [11] .…”

Section: Discussionmentioning

confidence: 74%

“…Specifically, the percentage of lymphocytes in the severe group was significantly lower than that in the mild group [8.90 (5.6-16.7) vs. 21.90 (10.90-29.8)], and the percentage of lymphocytes in the moderate group was also lower than that in the mild group [12.15] (7.52-21.62) vs. 21.90 (10.90-29.8)]. Notably, there was no significant difference in the percentage of lymphocytes between moderate and severe patients [11] .…”

Section: Discussionmentioning

confidence: 87%

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Predictive value of inflammatory factors and lymphocyte counts in tracheal intubation and death after infection with COVID-19

xu,

Zhang

2023

Preprint

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Objective This study aims to investigate the prognostic significance of inflammatory cytokines and lymphocyte levels in predicting disease progression among patients with COVID-19 infection.Methods Ninety-two hospitalized COVID-19 patients were retrospectively included as subjects for this study. General clinical information and various indicators, including lymphocyte count, interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor (TNF), were collected. All patients received treatment according to the ninth edition of the guidelines for COVID-19. Incidences of endotracheal intubation and mortality within 28 days were observed.Results 1.Lymphocyte count and inflammatory factors demonstrated predictive value for endotracheal intubation in COVID-19 patients. The critical lymphocyte count value was 0.91, with a sensitivity of 38.8%, specificity of 92.9%, and AUC of 0.687 (95% CI: 0.580–0.795). The critical IL-6 value was 38.21, with a sensitivity of 81%, specificity of 63.3%, and AUC of 0.771 (95% CI: 0.6670.872). The critical IL-8 value was 54.09, with a sensitivity of 61.9%, specificity of 75.5%, and AUC of 0.665 (95% CI: 0.545–0.771). The critical IL-10 value was 5.05, with a sensitivity of 71.4%, specificity of 65.3%, and AUC of 0.712 (95% CI: 0.601–0.813). The tumor necrosis factor cutoff was 1.98, with a sensitivity of 52.4%, specificity of 73.5%, and AUC of 0.648 (95% CI: 0.530–0.756). 2.Lymphocyte count and inflammatory factors also exhibited predictive value for death in COVID-19 patients. The critical lymphocyte count value was 0.56, with a sensitivity of 71.2%, specificity of 57.5%, and AUC of 0.641 (95% CI: 0.528–0.754). The critical IL-6 value was 53.05, with a sensitivity of 75%, specificity of 71.2%, and AUC of 0.770 (95% CI: 0.6690.870). The critical IL-8 value was 54.09, with a sensitivity of 62.5%, specificity of 63.5%, and AUC of 0.687 (95% CI: 0.5780.796). The critical IL-10 value was 5.05, with a sensitivity of 70%, specificity of 63.5%, and AUC of 0.683 (95% CI: 0.5740.792). The tumor necrosis factor cutoff was 0.98, with a sensitivity of 90%, specificity of 34.6%, and AUC of 0.636 (95% CI: 0.523–0.749).Conclusion Elevated inflammatory factors and decreased lymphocyte levels have prognostic value for predicting endotracheal intubation and mortality in COVID-19 patients, providing valuable insights for clinicians in anticipating disease progression.

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“…Specifically, the IL-6 level in the severe group was markedly higher than that in the moderate group was observed between the severe and mild COVID-19 groups [11] .…”

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 87%

Predictive value of inflammatory factors and lymphocyte counts in tracheal intubation and death after infection with COVID-19

xu,

Zhang

2023

Preprint

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“…It has been adequately proven that blood markers such as high-sensitivity troponin, fibrinogen, blood glucose, C-reactive protein, lactate dehydrogenase, albumin, and ferritin can predict lethal outcomes in patients with COVID-19, and that high lactate dehydrogenase accumulation itself is a potential predictor of disease severity [39][40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aerobic Exercise Therapy through Nordic Walking Program in Lactate Concentrations, Fatigue and Quality-of-Life in Patients with Long-COVID Syndrome: A Non-Randomized Parallel Controlled Trial

Laguarta-Val,

Varillas-Delgado,

Lizcano-Álvarez

et al. 2024

JCM

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Background: Long-COVID syndrome comprises a variety of signs and symptoms that develop during or after infection with COVID-19 which may affect the physical capabilities. However, there is a lack of studies investigating the effects of Long-COVID syndrome in sport capabilities after suffering from COVID-19 infection. The purpose of the study was to evaluate and compare lactate concentration and quality of life (QoL) in patients with Long-COVID with those who have not developed non-Long-COVID during Nordic walking exercise therapy. Methods: Twenty-nine patients (25.5 ± 7.1 years) took part in a non-randomized controlled trial, divided into two groups: a Long-COVID group (n = 16) and a non-Long-COVID control (n = 13). Patients were confirmed as having Long-COVID syndrome if they experienced fatigue or tiredness when performing daily activities and worsening of symptoms after vigorous physical or mental activity. All participants underwent a 12-week Nordic Walking program. Lactate concentration after exercise and distance covered during all sessions were measured. Pre- and Long-Nordic Walking program, the Modified Fatigue Impact Scale (MFIS), the Short Form 36 Health Survey (SF-36), and EURO QoL-5D (EQ-ED) were administered to assess fatigue and quality of life, respectively. Results: There was a lactate concentration effect between groups (F = 5.604; p = 0.024). However, there was no significant effect as a result of the session (F = 3.521; p = 0.121) with no interaction of group × session (F = 1.345; p = 0.414). The group main effect (F = 23.088; p < 0.001), time effect (F = 6.625; p = 0.026), and group × time (F = 4.632; p = 0.002) interaction on the SF-36 scale were noted. Also, there were a significant group main effect (F = 38.372; p < 0.001), time effect (F = 12.424; p = 0.005), and group × time interaction (F = 4.340; p = 0.014) on EQ-5D. However, there was only a significant group main effect (F = 26.235; p < 0.001) with no effect on time (F = 2.265; p = 0.160) and group × time (F = 1.584; p = 0.234) interaction on the MFIS scale. Conclusions: The Long-COVID group showed higher lactate concentration compared with the control group during the 12 weeks of the Nordic Walking program. The Long-COVID group presented a decrease in fatigue with respect to the control group according to the MFIS scale, as well as improvement in quality of life after aerobic exercise therapy.

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“…• Case Vignettes in Hematology: ChatGPT outperformed Google Bard and Microsoft Bing in solving hematologyrelated cases. It scored higher than the 50% threshold, suggesting its potential usefulness in medical education [61].…”

Section: Health Carementioning

confidence: 92%

Global Insights and the Impact of Generative AI-ChatGPT on Multidisciplinary: A Systematic Review and Bibliometric Analysis

Khan,

Koubaa

et al. 2024

Preprint

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Effect of COVID-19 on Stress and Biomarkers: An Exploratory Cross-Sectional Study

Cited by 3 publications

References 26 publications

Predictive value of inflammatory factors and lymphocyte counts in tracheal intubation and death after infection with COVID-19

Predictive value of inflammatory factors and lymphocyte counts in tracheal intubation and death after infection with COVID-19

Effects of Aerobic Exercise Therapy through Nordic Walking Program in Lactate Concentrations, Fatigue and Quality-of-Life in Patients with Long-COVID Syndrome: A Non-Randomized Parallel Controlled Trial

Global Insights and the Impact of Generative AI-ChatGPT on Multidisciplinary: A Systematic Review and Bibliometric Analysis

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