Effect of COVID‐19 on liver transplantation in Korea

Lee, Jeong‐Moo

doi:10.1111/tid.13384

Cited by 9 publications

(11 citation statements)

References 15 publications

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“…Other centers in areas where COVID-19 prevalence was low – or the infection reached its peak slowly – have continued their activity at a routine or even increased rate compared to 2019, being able in some cases to shunt COVID-19 affected patients elsewhere[ 17 - 20 ].…”

Section: Trends In Organ Donation and Transplant Activity During The mentioning

confidence: 99%

“…However, some centers have continued this practice even in high COVID-19 prevalence regions by creating COVID minimal-exposure pathways and reported favorable outcomes[ 3 , 22 , 23 ]. Surprisingly, data from South Korea showed that LDLT – the main type of transplantation performed in this county – did not significantly decrease even during the peak of the epidemic, thanks to a strict screening and tracing policy based on the experience of the previous Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) infection[ 20 ].…”

Section: Living Donor Liver Transplantation Activity During the Pandementioning

confidence: 99%

“…Staff members contracting the disease or in quarantine can result in the shutdown of a program for weeks. Organ recovery teams moving across centers and regions are exposed to the risk of transmission, and they must take appropriate respiratory and contact precautions throughout the procedure, even if the donor tested negative[ 15 , 20 ]. To reduce the exposure of recovery teams, many transplant centers have started relying on local teams and information sharing between centers via secure digital platforms[ 3 ].…”

Section: Transplant-related Transmission and Utilization Of Covid-posmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature

Carlis

Vella

Incarbone

et al. 2021

WJG

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The coronavirus disease 2019 (COVID-19) pandemic has upended healthcare systems worldwide and led to an inevitable decrease in liver transplantation (LT) activity. During the first pandemic wave, administrators and clinicians were obliged to make the difficult decision of whether to suspend or continue a life-saving procedure based on the scarce available evidence regarding the risk of transmission and mortality in immunosuppressed patients. Those centers where the activity continued or was heavily restricted were obliged to screen donors and recipients, design COVID-safe clinical pathways, and promote telehealth to prevent nosocomial transmission. Despite the ever-growing literature on COVID-19, the amount of high-quality literature on LT remains limited. This review will provide an updated view of the impact of the pandemic on LT programs worldwide. Donor and recipient screening, strategies for waitlist prioritization, and posttransplant risk of infection and mortality are discussed. Moreover, a particular focus is given to the possibility of donor-to-recipient transmission and immunosuppression management in COVID-positive recipients.

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Section: Trends In Organ Donation and Transplant Activity During The mentioning

confidence: 99%

Section: Living Donor Liver Transplantation Activity During the Pandementioning

confidence: 99%

Section: Transplant-related Transmission and Utilization Of Covid-posmentioning

confidence: 99%

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Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature

Carlis

Vella

Incarbone

et al. 2021

WJG

View full text Add to dashboard Cite

show abstract

“…This effect was predominant in the beginning of the pandemic, improving somewhat after the centers established segregated patient flows to avoid cross‐contamination. 4 , 5 , 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

Pediatric liver transplantation activity in a high‐volume program during the COVID‐19 pandemic in Brazil

Fonseca

Feier

Pugliese

et al. 2021

Pediatric Transplantation

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Background The impact of the COVID pandemic on liver transplant (LT) programs varied among countries. Few data are available about that impact in pediatric liver transplant (PLT) programs. This study aimed at comparing the data of our program in Brazil (2019 vs. 2020). Methods Retrospective cohort study. Results One hundred and seventy‐four PLT were performed in the period (93% living donors). Patients were divided into two groups according to the LT date: pre‐COVID‐19 period (march/2019–February/2020) and COVID‐19 period (March/2020–February 2021). In the pre‐COVID‐19 period, 97 LTs were performed, and 77 LTs were performed in the COVID‐19 period. Patients in the COVID‐19 period were younger (10.9 months vs. 16 months, p 0.009), had higher PELD scores (15 vs. 14, p 0.04), more ascites (66.2 vs. 51.5%, p 0.03), and more frequently hospitalized before LT (27.3 vs. 17.5%). However, there was no difference in post‐LT complications, retransplantation nor survival rates. Six (6.2%) patients from pre‐COVID‐19 period were COVID positive at a median of 15.5 months (14–17.5), and 6 (7.8%) patients from COVID‐19 period were COVID positive at a median of 3 months (20 days–6 months) from LT. There was neither mortality nor complications in those patients. Four (33%) were hospitalized, and one had prolonged intubation. Four (33%) were asymptomatic, 4 (33%) had upper airways symptoms, and the remaining had gastrointestinal symptoms. Conclusion Overall, PLT was not affected during COVID‐19 period. Even though patients from COVID‐19 period were sicker, there was no significant impact in LT outcomes. All the recipients who tested positive for COVID had a favorable outcome.

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“…In Europe, the COVID-19 pandemic was reported to have had a similarly severe impact on transplant medical care, with the number of referrals of potential donors decreasing by 39% in the United Kingdom [ 36 ] and the number of potential deceased organ donors decreasing by 16% in comparison with previous years in France [ 37 ]. Conversely, in South Korea, (as in Japan), where the COVID-19 pandemic manifested relatively early with a less impact than in the United States and Europe, there was no significant change reported in the number of liver transplantations or kidney transplantations as of March and April, 2020 [ 38 , 39 ], respectively, from the previous year, for both living donor transplants and BDD transplants. These findings showed that the ability to perform organ transplantation is dependent on the severity of the spread of COVID-19 in a given country; however, as these reports relate to the situation in spring 2020, subsequent reports on the overall situation of organ transplantation in 2020 are awaited.…”

Section: Discussionmentioning

confidence: 99%

National survey on deceased donor organ transplantation during the COVID-19 pandemic in Japan

et al. 2021

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Purpose We investigated the status of deceased organ donation and transplantation through a questionnaire distributed to transplant centers in Japan during the COVID-19 pandemic. Methods The questionnaire was distributed electronically to 206 transplant centers for heart (n = 11), lung (n = 10), liver (n = 25), kidney (n = 130), pancreas (n = 18), and small intestine (n = 12) transplantation. Organ donations and organ transplantation data were extracted from the Japan Organ Transplant Network website. Results We received questionnaire responses from 177 centers (response rate, 86%). In 2020, the number of brain-dead donors (BDDs) decreased to 68 (69% of the year-on-year average) and the number of donors after cardiac death (DCDs) decreased to 9 (32% of the year-on-year average). Eighty-five (48%) transplant centers (heart, n = 0; lung, n = 0; liver, n = 4; kidney, n = 78; pancreas, n = 22; and small intestine, n = 0) suspended transplant surgeries in response to the COVID-19 pandemic. Consequently, the number of organ transplantations from deceased donors was significantly lower in 2020 than in 2019. Conclusion Although the COVID-19 pandemic has had less impact in Japan than in other countries, it has affected transplantation activity significantly, suspending transplantation surgeries in 48% of the transplantation centers, including 78% of the kidney transplantation centers, and reducing the number of organ donations to 61% of the year-on-year average.

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Effect of COVID‐19 on liver transplantation in Korea

Cited by 9 publications

References 15 publications

Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature

Impact of the COVID-19 pandemic on liver donation and transplantation: A review of the literature

Pediatric liver transplantation activity in a high‐volume program during the COVID‐19 pandemic in Brazil

National survey on deceased donor organ transplantation during the COVID-19 pandemic in Japan

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